Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration

Ben, Michel; Trusley, Craig; Kupiec, Thomas C; Trissel, Lawrence A; Ben, Michel; Trusley, Craig; Kupiec, Thomas C; Trissel, Lawrence A

Abstract

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration

Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A

Issue: Nov/Dec 2007 - High-Technology Compounding

View All Articles in Issue

Page(s): 520-524

Download in electronic PDF format for $75

Abstract

Palonosetron hydrochloride is a relatively long-acting selective 5-HT3 receptor antagonist that has been approved for the prevention of chemotherapy-induced nausea and vomiting and is being evaluated for the prevention of postoperative nausea and vomiting. The objective of this study was to evaluate the physical and chemical stability of palonosetron hydrochloride 50 mcg/mL with the b-lactam antibiotics cefazolin sodium 20 mg/mL, cefotetan disodium 20 mg/mL, and the combination ampicillin sodium–sulbactam sodium 20 mg/mL and 10 mg/mL, respectively, during simulated Y-site administration. The effects of each of the antibiotics on palonosetron hydrochloride in these admixtures were tested in triplicate. Samples were stored and evaluated for up to 4 hours at room temperature. Physical stability was assessed by turbidimetric and particulate measurements and visual inspection. Chemical stability was assessed by high-performance liquid chromatography. All of the admixtures were clear and colorless when viewed in normal fluorescent room light and when viewed with a Tyndall beam. Measured turbidity and particulate content were low initially and remained low throughout the study. The drug concentration was unchanged in all of the samples tested. Palonosetron hydrochloride is physically and chemically stable in admixtures with cefazolin sodium, cefotetan disodium, and the combination ampicillin sodium–sulbactam sodium at the concentrations tested during simulated Y-site administration over 4 hours at ambient room temperature.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Nov/Dec 2007 Pg. 520-524	Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008 Pg. 156-160	Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration Author(s): Trusley Craig, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008 Pg. 170-173	Compatibility and Stability of Palonosetron Hydrochloride with Gentamicin, Metronidazole, or Vancomycin During Simulated Y-Site Administration Author(s): Kupiec Thomas C, Ben Michel, Trusley Craig, Trissel Lawrence A
Jan/Feb 2009 Pg. 78-80	Compatibility and Stability of Palonosetron Hydrochloride and Propofol During Simulated Y-Site Administration Author(s): Trissel Lawrence A, Trusley Craig, Kupiec Thomas C, Ben Michel
Jul/Aug 2008 Pg. 368-371	Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Sep/Oct 2008 Pg. 460-462	Compatibility and Stability of Palonosetron Hydrochloride with Lactated Ringer's, Hetastarch in Lactated Electrolyte, and Mannitol Injections During Simulated Y-Site Administration Author(s): Ben Michel, Kupiec Thomas C, Trusley Craig, Trissel Lawrence A
Jan/Feb 2017 Pg. 76-82	Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride Author(s): Wu George, Yeung Stanley, Chen Frank
May/Jun 2005 Pg. 238-241	Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A
Jul/Aug 2002 Pg. 311-315	Compatibility Screening of Bivalirudin During Simulated Y-Site Administration with Other Drugs Author(s): Trissel Lawrence A, Saenz Christopher
Jul/Aug 2016 Pg. 328-332	Y-site Physical Compatibility of Beta-blocker Infusions with Intensive Care Unit Admixtures Author(s): Foushee Jaime A, Meredith Pmichaele, Fox Laura M, Grace EdwardE
May/Jun 2005 Pg. 235-237	Physical and Chemical Stability of Palonosetron Hydrochloride with Lorazepam and Midazolam Hydrochloride during Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A
Jan/Feb 2018 Pg. 76-85	Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride Injection and Dexamethasone Sodium Phosphate Injection Author(s): Wu George, Powers Dan, Yeung Stanley, Chen Frank
May/Jun 2008 Pg. 276-278	Compatibility of Caspofungin Acetate Injection with Other Drugs During Simulated Y-Site Coadministration Author(s): Chan Pak, Heatherly Kathy, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2001 Pg. 69-73	Compatibility Screening of Hextend During Simulated Y-Site Administration with Other Drugs Author(s): Trissel Lawrence A, Williams Kimberly Y, Baker Ma
Sep/Oct 2013 Pg. 436-438	Compatibility of Amiodarone Hydrochloride with Vasopressin During Simulated Y-site Administration Author(s): Ramaley Corrine C, Li Feng, Du Chengan
Jan/Feb 2018 Pg. 86-94	Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Granisetron Hydrochloride Author(s): Wu George, Powers Dan, Yeung Stanley, Chen Frank, Neelon Kelly
Jan/Feb 2021 Pg. 52-61	Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration Author(s): Lu Juan, Liu Qiang, Kupiec Thomas C, Vail Herbert, Lynch Leslie R, Fam David S, Vu Nicole T
May/Jun 2006 Pg. 234-236	Physical and Chemical Stability of Palonosetron Hydrochloride with Dacarbazine and with Methylprednisolone Sodium Succinate During Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A, Zhang Yanping
May/Jun 2006 Pg. 230-233	Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration Author(s): Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2007 Pg. 82-85	Physical and Chemical Stability of Palonosetron with Metoclopramide and Promethazine During Simulated Y-Site Administration Author(s): Trusley Craig, Ben Michel, Kupiec Thomas C, Trissel Lawrence A

Abstract

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration

Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A

Issue: Nov/Dec 2007 - High-Technology Compounding

View All Articles in Issue

Page(s): 520-524

Download in electronic PDF format for $75

Abstract

Palonosetron hydrochloride is a relatively long-acting selective 5-HT3 receptor antagonist that has been approved for the prevention of chemotherapy-induced nausea and vomiting and is being evaluated for the prevention of postoperative nausea and vomiting. The objective of this study was to evaluate the physical and chemical stability of palonosetron hydrochloride 50 mcg/mL with the b-lactam antibiotics cefazolin sodium 20 mg/mL, cefotetan disodium 20 mg/mL, and the combination ampicillin sodium–sulbactam sodium 20 mg/mL and 10 mg/mL, respectively, during simulated Y-site administration. The effects of each of the antibiotics on palonosetron hydrochloride in these admixtures were tested in triplicate. Samples were stored and evaluated for up to 4 hours at room temperature. Physical stability was assessed by turbidimetric and particulate measurements and visual inspection. Chemical stability was assessed by high-performance liquid chromatography. All of the admixtures were clear and colorless when viewed in normal fluorescent room light and when viewed with a Tyndall beam. Measured turbidity and particulate content were low initially and remained low throughout the study. The drug concentration was unchanged in all of the samples tested. Palonosetron hydrochloride is physically and chemically stable in admixtures with cefazolin sodium, cefotetan disodium, and the combination ampicillin sodium–sulbactam sodium at the concentrations tested during simulated Y-site administration over 4 hours at ambient room temperature.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Nov/Dec 2007 Pg. 520-524	Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008 Pg. 156-160	Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration Author(s): Trusley Craig, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008 Pg. 170-173	Compatibility and Stability of Palonosetron Hydrochloride with Gentamicin, Metronidazole, or Vancomycin During Simulated Y-Site Administration Author(s): Kupiec Thomas C, Ben Michel, Trusley Craig, Trissel Lawrence A
Jan/Feb 2009 Pg. 78-80	Compatibility and Stability of Palonosetron Hydrochloride and Propofol During Simulated Y-Site Administration Author(s): Trissel Lawrence A, Trusley Craig, Kupiec Thomas C, Ben Michel
Jul/Aug 2008 Pg. 368-371	Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Sep/Oct 2008 Pg. 460-462	Compatibility and Stability of Palonosetron Hydrochloride with Lactated Ringer's, Hetastarch in Lactated Electrolyte, and Mannitol Injections During Simulated Y-Site Administration Author(s): Ben Michel, Kupiec Thomas C, Trusley Craig, Trissel Lawrence A
Jan/Feb 2017 Pg. 76-82	Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride Author(s): Wu George, Yeung Stanley, Chen Frank
May/Jun 2005 Pg. 238-241	Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A
Jul/Aug 2002 Pg. 311-315	Compatibility Screening of Bivalirudin During Simulated Y-Site Administration with Other Drugs Author(s): Trissel Lawrence A, Saenz Christopher
Jul/Aug 2016 Pg. 328-332	Y-site Physical Compatibility of Beta-blocker Infusions with Intensive Care Unit Admixtures Author(s): Foushee Jaime A, Meredith Pmichaele, Fox Laura M, Grace EdwardE
May/Jun 2005 Pg. 235-237	Physical and Chemical Stability of Palonosetron Hydrochloride with Lorazepam and Midazolam Hydrochloride during Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A
Jan/Feb 2018 Pg. 76-85	Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride Injection and Dexamethasone Sodium Phosphate Injection Author(s): Wu George, Powers Dan, Yeung Stanley, Chen Frank
May/Jun 2008 Pg. 276-278	Compatibility of Caspofungin Acetate Injection with Other Drugs During Simulated Y-Site Coadministration Author(s): Chan Pak, Heatherly Kathy, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2001 Pg. 69-73	Compatibility Screening of Hextend During Simulated Y-Site Administration with Other Drugs Author(s): Trissel Lawrence A, Williams Kimberly Y, Baker Ma
Sep/Oct 2013 Pg. 436-438	Compatibility of Amiodarone Hydrochloride with Vasopressin During Simulated Y-site Administration Author(s): Ramaley Corrine C, Li Feng, Du Chengan
Jan/Feb 2018 Pg. 86-94	Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Granisetron Hydrochloride Author(s): Wu George, Powers Dan, Yeung Stanley, Chen Frank, Neelon Kelly
Jan/Feb 2021 Pg. 52-61	Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration Author(s): Lu Juan, Liu Qiang, Kupiec Thomas C, Vail Herbert, Lynch Leslie R, Fam David S, Vu Nicole T
May/Jun 2006 Pg. 234-236	Physical and Chemical Stability of Palonosetron Hydrochloride with Dacarbazine and with Methylprednisolone Sodium Succinate During Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A, Zhang Yanping
May/Jun 2006 Pg. 230-233	Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration Author(s): Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2007 Pg. 82-85	Physical and Chemical Stability of Palonosetron with Metoclopramide and Promethazine During Simulated Y-Site Administration Author(s): Trusley Craig, Ben Michel, Kupiec Thomas C, Trissel Lawrence A