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Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration

Author(s):  Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A

Issue:  Nov/Dec 2007 - High-Technology Compounding
View All Articles in Issue

Page(s):  520-524

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 1
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 2
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 3
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 4
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 5

Download in electronic PDF format for $75

Abstract:  Palonosetron hydrochloride is a relatively long-acting selective 5-HT3 receptor antagonist that has been approved for the prevention of chemotherapy-induced nausea and vomiting and is being evaluated for the prevention of postoperative nausea and vomiting. The objective of this study was to evaluate the physical and chemical stability of palonosetron hydrochloride 50 mcg/mL with the b-lactam antibiotics cefazolin sodium 20 mg/mL, cefotetan disodium 20 mg/mL, and the combination ampicillin sodium–sulbactam sodium 20 mg/mL and 10 mg/mL, respectively, during simulated Y-site administration. The effects of each of the antibiotics on palonosetron hydrochloride in these admixtures were tested in triplicate. Samples were stored and evaluated for up to 4 hours at room temperature. Physical stability was assessed by turbidimetric and particulate measurements and visual inspection. Chemical stability was assessed by high-performance liquid chromatography. All of the admixtures were clear and colorless when viewed in normal fluorescent room light and when viewed with a Tyndall beam. Measured turbidity and particulate content were low initially and remained low throughout the study. The drug concentration was unchanged in all of the samples tested. Palonosetron hydrochloride is physically and chemically stable in admixtures with cefazolin sodium, cefotetan disodium, and the combination ampicillin sodium–sulbactam sodium at the concentrations tested during simulated Y-site administration over 4 hours at ambient room temperature.

Related Keywords: Michel Ben, MS, Craig Trusley, PharmD, MS, Thomas C. Kupiec, PhD, Lawrence A. Trissel, BS, RPh, FASHP, palonosetron hydrochloride, antiemetic agent, vomiting, 5-HT3 receptor antagonist, stability, compatibility, drug admixtures, beta-lactam antibiotics, cefazolin sodium, ampicillin sodium sulbactam sodium, cefotetan sodium, parenteral administration, infusion

Related Categories: GASTROENTEROLOGY, PARENTERALS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, INFECTIOUS DISEASE, NEUROLOGY

Printer-Friendly Version



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(Click for Abstract / Details / Purchase)
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Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Nov/Dec 2007
Pg. 520-524

Compatibility and Stability of Palonosetron Hydrochloride with Gentamicin, Metronidazole, or Vancomycin During Simulated Y-Site Administration
Kupiec Thomas C
, Ben Michel, Trusley Craig, Trissel Lawrence A
Mar/Apr 2008
Pg. 170-173

Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration
Trusley Craig
, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008
Pg. 156-160

Compatibility and Stability of Palonosetron Hydrochloride and Propofol During Simulated Y-Site Administration
Trissel Lawrence A
, Trusley Craig, Kupiec Thomas C, Ben Michel
Jan/Feb 2009
Pg. 78-80

Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jul/Aug 2008
Pg. 368-371

Compatibility and Stability of Palonosetron Hydrochloride with Lactated Ringer's, Hetastarch in Lactated Electrolyte, and Mannitol Injections During Simulated Y-Site Administration
Ben Michel
, Kupiec Thomas C, Trusley Craig, Trissel Lawrence A
Sep/Oct 2008
Pg. 460-462

Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration
Trusley Craig
, Kupiec Thomas C, Trissel Lawrence A
May/Jun 2006
Pg. 230-233

Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration
Trissel Lawrence A
, Xu Quanyun A
May/Jun 2005
Pg. 238-241

Compatibility of Caspofungin Acetate Injection with Other Drugs During Simulated Y-Site Coadministration
Chan Pak
, Heatherly Kathy, Kupiec Thomas C, Trissel Lawrence A
May/Jun 2008
Pg. 276-278

Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride during Simulated Y-site Administration
Trissel Lawrence A
, Zhang Yanping
Jul/Aug 2005
Pg. 320-322

Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration
Lu Juan
, Liu Qiang, Kupiec Thomas C, Vail Herbert, Lynch Leslie R, Fam David S, Vu Nicole T
Jan/Feb 2021
Pg. 52-61

Physical and Chemical Stability of Palonosetron Hydrochloride with Lorazepam and Midazolam Hydrochloride during Simulated Y-Site Administration
Trissel Lawrence A
, Xu Quanyun A
May/Jun 2005
Pg. 235-237

Compatibility Screening of Bivalirudin During Simulated Y-Site Administration with Other Drugs
Trissel Lawrence A
, Saenz Christopher
Jul/Aug 2002
Pg. 311-315

Compatibility of Amiodarone Hydrochloride with Vasopressin During Simulated Y-site Administration
Ramaley Corrine C
, Li Feng, Du Chengan
Sep/Oct 2013
Pg. 436-438

Compatibility of Norepinephrine Bitartrate with Levofloxacin and Moxifloxacin During Simulated Y-site Administration
Mody Vicky
, Shah Samit, Patel Jaymin, Thomas Michael C
May/Jun 2016
Pg. 236-238

Physical and Chemical Stability of Palonosetron with Metoclopramide and Promethazine During Simulated Y-Site Administration
Trusley Craig
, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2007
Pg. 82-85

Physical and Chemical Stability of Palonosetron Hydrochloride with Dacarbazine and with Methylprednisolone Sodium Succinate During Simulated Y-Site Administration
Trissel Lawrence A
, Xu Quanyun A, Zhang Yanping
May/Jun 2006
Pg. 234-236

Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride
Wu George
, Yeung Stanley, Chen Frank
Jan/Feb 2017
Pg. 76-82

Compatibility and Stability of Ranitidine Hydrochloride with Six Cephalosporins During Simulated Y-Site Administration
Inagaki Kazuhiro
, Kambara Motoya, Mizuno Munemichi, Gill Mark A, Nishida Mikio
Jul/Aug 1998
Pg. 318-321

Compatibility Screening of Hextend During Simulated Y-Site Administration with Other Drugs
Trissel Lawrence A
, Williams Kimberly Y, Baker Ma
Jan/Feb 2001
Pg. 69-73

Return to Top

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration

Author(s):  Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A

Issue:  Nov/Dec 2007 - High-Technology Compounding
View All Articles in Issue

Page(s):  520-524

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 1
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 2
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 3
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 4
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Page 5

Download in electronic PDF format for $75

Abstract:  Palonosetron hydrochloride is a relatively long-acting selective 5-HT3 receptor antagonist that has been approved for the prevention of chemotherapy-induced nausea and vomiting and is being evaluated for the prevention of postoperative nausea and vomiting. The objective of this study was to evaluate the physical and chemical stability of palonosetron hydrochloride 50 mcg/mL with the b-lactam antibiotics cefazolin sodium 20 mg/mL, cefotetan disodium 20 mg/mL, and the combination ampicillin sodium–sulbactam sodium 20 mg/mL and 10 mg/mL, respectively, during simulated Y-site administration. The effects of each of the antibiotics on palonosetron hydrochloride in these admixtures were tested in triplicate. Samples were stored and evaluated for up to 4 hours at room temperature. Physical stability was assessed by turbidimetric and particulate measurements and visual inspection. Chemical stability was assessed by high-performance liquid chromatography. All of the admixtures were clear and colorless when viewed in normal fluorescent room light and when viewed with a Tyndall beam. Measured turbidity and particulate content were low initially and remained low throughout the study. The drug concentration was unchanged in all of the samples tested. Palonosetron hydrochloride is physically and chemically stable in admixtures with cefazolin sodium, cefotetan disodium, and the combination ampicillin sodium–sulbactam sodium at the concentrations tested during simulated Y-site administration over 4 hours at ambient room temperature.

Related Keywords: Michel Ben, MS, Craig Trusley, PharmD, MS, Thomas C. Kupiec, PhD, Lawrence A. Trissel, BS, RPh, FASHP, palonosetron hydrochloride, antiemetic agent, vomiting, 5-HT3 receptor antagonist, stability, compatibility, drug admixtures, beta-lactam antibiotics, cefazolin sodium, ampicillin sodium sulbactam sodium, cefotetan sodium, parenteral administration, infusion

Related Categories: GASTROENTEROLOGY, PARENTERALS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, INFECTIOUS DISEASE, NEUROLOGY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Nov/Dec 2007
Pg. 520-524

Compatibility and Stability of Palonosetron Hydrochloride with Gentamicin, Metronidazole, or Vancomycin During Simulated Y-Site Administration
Kupiec Thomas C
, Ben Michel, Trusley Craig, Trissel Lawrence A
Mar/Apr 2008
Pg. 170-173

Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration
Trusley Craig
, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008
Pg. 156-160

Compatibility and Stability of Palonosetron Hydrochloride and Propofol During Simulated Y-Site Administration
Trissel Lawrence A
, Trusley Craig, Kupiec Thomas C, Ben Michel
Jan/Feb 2009
Pg. 78-80

Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jul/Aug 2008
Pg. 368-371

Compatibility and Stability of Palonosetron Hydrochloride with Lactated Ringer's, Hetastarch in Lactated Electrolyte, and Mannitol Injections During Simulated Y-Site Administration
Ben Michel
, Kupiec Thomas C, Trusley Craig, Trissel Lawrence A
Sep/Oct 2008
Pg. 460-462

Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration
Trusley Craig
, Kupiec Thomas C, Trissel Lawrence A
May/Jun 2006
Pg. 230-233

Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration
Trissel Lawrence A
, Xu Quanyun A
May/Jun 2005
Pg. 238-241

Compatibility of Caspofungin Acetate Injection with Other Drugs During Simulated Y-Site Coadministration
Chan Pak
, Heatherly Kathy, Kupiec Thomas C, Trissel Lawrence A
May/Jun 2008
Pg. 276-278

Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride during Simulated Y-site Administration
Trissel Lawrence A
, Zhang Yanping
Jul/Aug 2005
Pg. 320-322

Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration
Lu Juan
, Liu Qiang, Kupiec Thomas C, Vail Herbert, Lynch Leslie R, Fam David S, Vu Nicole T
Jan/Feb 2021
Pg. 52-61

Physical and Chemical Stability of Palonosetron Hydrochloride with Lorazepam and Midazolam Hydrochloride during Simulated Y-Site Administration
Trissel Lawrence A
, Xu Quanyun A
May/Jun 2005
Pg. 235-237

Compatibility Screening of Bivalirudin During Simulated Y-Site Administration with Other Drugs
Trissel Lawrence A
, Saenz Christopher
Jul/Aug 2002
Pg. 311-315

Compatibility of Amiodarone Hydrochloride with Vasopressin During Simulated Y-site Administration
Ramaley Corrine C
, Li Feng, Du Chengan
Sep/Oct 2013
Pg. 436-438

Compatibility of Norepinephrine Bitartrate with Levofloxacin and Moxifloxacin During Simulated Y-site Administration
Mody Vicky
, Shah Samit, Patel Jaymin, Thomas Michael C
May/Jun 2016
Pg. 236-238

Physical and Chemical Stability of Palonosetron with Metoclopramide and Promethazine During Simulated Y-Site Administration
Trusley Craig
, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2007
Pg. 82-85

Physical and Chemical Stability of Palonosetron Hydrochloride with Dacarbazine and with Methylprednisolone Sodium Succinate During Simulated Y-Site Administration
Trissel Lawrence A
, Xu Quanyun A, Zhang Yanping
May/Jun 2006
Pg. 234-236

Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride
Wu George
, Yeung Stanley, Chen Frank
Jan/Feb 2017
Pg. 76-82

Compatibility and Stability of Ranitidine Hydrochloride with Six Cephalosporins During Simulated Y-Site Administration
Inagaki Kazuhiro
, Kambara Motoya, Mizuno Munemichi, Gill Mark A, Nishida Mikio
Jul/Aug 1998
Pg. 318-321

Compatibility Screening of Hextend During Simulated Y-Site Administration with Other Drugs
Trissel Lawrence A
, Williams Kimberly Y, Baker Ma
Jan/Feb 2001
Pg. 69-73

Return to Top