Abstract

Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together

Author(s): Gupta Vishnu D

Issue: May/Jun 2006 - Hormone Replacement Therapy

Page(s): 237-239

Download in electronic PDF format for $75
  • Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together Page 1
  • Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together Page 2
  • Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together Page 3

Abstract

The stability of diphenhydramine hydrochloride (from an elixir) and lidocaine hydrochloride (from a viscous solution) in a mixture (1:1) was studied using a stability-indicating highperformance liquid chromatographic assay method. The concentrations of the drugs were related directly to peak heights, and the percent relative standard deviations based on five injections were 1.4 for diphenhydramine and 1.3 for lidocaine. The products of hydrolysis from the both the drugs and a number of excipients present in the dosage forms did not interfere with the developed assay procedure. The mixture was stable for at least 21 days when stored in amber-colored bottles at room temperature. The pH value of the mixture remained constant, and the physical appearance did not change during the study period.

Related Keywords

  • diphenhydramine hydrochloride
  • antihistamine
  • lidocaine hydrochloride
  • anesthetic agent
  • excipients
  • vehicles
  • drug admixtures
  • stability

Related Categories

  • EXCIPIENTS
  • PAIN MANAGEMENT
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • ALLERGY/IMMUNOLOGY/INFLAMMATION

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
May/Jun 2006
Pg. 237-239
Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together
Author(s): Gupta Vishnu D
Jan/Feb 2019
Pg. 54
Lidocaine Hydrochloride, Diphenhydramine Hydrochloride, Aluminum Hydroxide–Magnesium Hydrochloride–Simethicone Mouthwashes
Author(s): Allen Loyd V Jr
May/Jun 2015
Pg. 243
Lidocaine Hydrochloride 2% Viscous Oral Topical Solution
Author(s): Allen Loyd V Jr
Mar/Apr 2025
Pg. 127
Lidocaine Hydrochloride, Diphenhydramine Hydrochloride, Aluminum Hydroxide-Magnesium Hydroxide-Simethicone Mouthwashes
Author(s):
Nov/Dec 2018
Pg. 516-526
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Author(s): Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
Jul/Aug 2001
Pg. 310-312
Wetting and/or Solubilizing Agents, Featured Excipient:
Author(s): Allen Loyd V Jr
Jan/Feb 2009
Pg. 69
Diphenhydramine Hydrochloride 25-mg Gelatin Troches
Author(s): Allen Loyd V Jr
Jul/Aug 2012
Pg. 334
Diphenhydramine Hydrochloride 50-mg/mL Injection
Author(s): Allen Loyd V Jr
Jan/Feb 2002
Pg. 66-69
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes
Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Jan/Feb 2002
Pg. 70-73
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes
Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
May/Jun 2005
Pg. 238-241
Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration
Author(s): Trissel Lawrence A, Xu Quanyun A
Mar/Apr 2020
Pg. 168-175
Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel
Author(s): Dahal Amit, Neupane Rabin, Boddu Sai HS, Renukuntla Jwala, Khupse Rahul, Dudley Richard
Sep/Oct 2007
Pg. 416
Acetaminophen 500-mg and Diphenhydramine Hydrochloride 25-mg Hot Therapy Packs
Author(s): Allen Loyd V Jr
Jan/Feb 2015
Pg. 67
Lidocaine Hydrochloride 4% Topical Solution
Author(s): Allen Loyd V Jr
Sep/Oct 2002
Pg. 388-390
Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Nov/Dec 2004
Pg. 476
Lidocaine Hydrochloride 4%, Epinephrine Hydrochloride 0.05%, and Tetracaine Hydrochloride 0.5% Topical Spray
Author(s): Allen Loyd V Jr
Nov/Dec 2007
Pg. 511
Lidocaine Hydrochloride 1.82% Buffered Injection
Author(s): Allen Loyd V Jr
May/Jun 2020
Pg. 252-262
Stability of Azathioprine, Clonidine Hydrochloride, Clopidogrel Bisulfate, Ethambutol Hydrochloride, Griseofulvin, Hydralazine Hydrochloride, Nitrofurantoin, and Thioguanine Oral Suspensions Compounded with SyrSpend SF pH4
Author(s): Polonini Hudson, Loures da Silva Sharlene, Neves Cunha Carolina, de Oliveira Ferreira Anderson, Anagnostou Korina, Dijkers Eli
Jul/Aug 2020
Pg. 320
Sumatriptan, Lidocaine Hydrochloride, Dexamethasone, Pentoxifylline, and Ibuprofen Transdermal Cream (Migraine Cream)
Author(s): Allen Loyd V Jr
Nov/Dec 2010
Pg. 520
Ketoprofen 5% and Lidocaine Hydrochloride 0.5% Topical Gel
Author(s): Allen Loyd V Jr