Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes

Storms, Meredith L; Stewart, James T; Warren, Flynn W

A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

LEARN MORE

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes

Author(s): Storms Meredith L, Stewart James T, Warren Flynn W

Issue: Sep/Oct 2002 - Veterinary Compounding
View All Articles in Issue

Page(s): 388-390

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Page 1

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Page 2

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Page 3

Download in electronic PDF format for $75

Abstract: The stability of 20 mg/mL lidocaine hydrochloride injection in 12-mL polypropylene syringes stored at ambient temperature and at 4°C for up to 90 days was investigated. A highperformance liquid chromatographic stability-indicating assay was used to determine the concentration level of lidocaine hydrochloride injection at 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes. Methylparaben, which was added as a preservative, did not interfere with the assay. The injections in plastic syringes were stable for up to 90 days at both ambient temperature and at 4°C. The pH of lidocaine hydrochloride injection did not change appreciably during the 90-day study period. These data indicate the stability of lidocaine hydrochloride under the storage conditions investigated in this study.

Related Keywords: Lidocaine hydrochloride injection, effect of temperature on stability of, Lidocaine hydrochloride injection, stability of during storage

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W	Sep/Oct 2002 Pg. 388-390
Stability of Neostigmine Methylsulfate Injection at Ambient Temperature and 4°C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W	Nov/Dec 2002 Pg. 475-477
Stability of Glycopyrrolate Injection at Ambient Temperature and 4°C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W	Jan/Feb 2003 Pg. 65-67
Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes Stewart James T, Storms Meredith L, Warren Flynn W	Jul/Aug 2002 Pg. 308-310
Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W	Jan/Feb 2003 Pg. 68-70
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Zhang Yan-ping, Trissel Lawrence A	Mar/Apr 1997 Pg. 132-134
Stability of Ephedrine Sulfate at Ambient Temperature and 4°C in Polypropylene Syringes Storms Meredith L, Stewart James T, Warren Flynn W	Sep/Oct 2001 Pg. 394-396
Magnesium Sulfate and Lidocaine Hydrochloride Injection in Prefilled Syringes Allen Loyd V Jr	Jan/Feb 2019 Pg. 55
Lidocaine Hydrochloride 1% Injection Allen Loyd V Jr	May/Jun 2014 Pg. 237
Lidocaine Hydrochloride 1.82% Buffered Injection Allen Loyd V Jr	Nov/Dec 2007 Pg. 511
Lidocaine Hydrochloride-2%, Ketolorac Tromethamine-3%, and Clonidine Hydrochloride-0.1% Injection Allen Loyd V Jr	Jan/Feb 2005 Pg. 66
Stability of Ketamine Hydrochloride Injection After Reconstitution in Water for Injection and Storage in 1-mL Tuberculin Polypropylene Syringes for Pediatric Use Gupta Vishnu D	Jul/Aug 2002 Pg. 316-317
Stability of Levothyroxine Sodium Injection in Polypropylene Syringes Gupta Vishnu D	Nov/Dec 2000 Pg. 482-483
Chemical Stability of Metoclopramide Hydrochloride Injection Diluted with 0.9% Sodium Chloride Injection in Polypropylene Syringes at Room Temperature Gupta Vishnu D	Jan/Feb 2005 Pg. 72-74
Long-term Stability of Morphine Hydrochloride in 0.9% NaCl Infusion Polyolefin Bags After Freeze-thaw Treatment and in Polypropylene Syringes at 5°C ± 3°C Hecq J-D, Godet M, Gillet P, Jamart J, Galanti L	Jan/Feb 2014 Pg. 78-82
Lidocaine Hydrochloride, Diphenhydramine Hydrochloride, Aluminum Hydroxide–Magnesium Hydrochloride–Simethicone Mouthwashes Allen Loyd V Jr	Jan/Feb 2019 Pg. 54
Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs. Xu Quanyun A, Trissel Lawrence A, Pham Lien	May/Jun 2004 Pg. 228-230
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes Xu Quanyun A, Trissel Lawrence A, Pham Lien	Jan/Feb 2002 Pg. 66-69
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes Trissel Lawrence A, Xu Quanyun A, Pham Lien	Jan/Feb 2002 Pg. 70-73
Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together Gupta Vishnu D	May/Jun 2006 Pg. 237-239
Return to Top