Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Compatibility of Paclitaxel Injection Diluent with Two Reduced-Phthalate Administration Sets for the Acclaim Pump

Author(s):  Xu Quanyun A, Trissel Lawrence A

Issue:  Sep/Oct 1998 - Parenteral Nutrition Solutions
View All Articles in Issue

Page(s):  382-384

Compatibility of Paclitaxel Injection Diluent with Two Reduced-Phthalate Administration Sets for the Acclaim Pump Page 1
Compatibility of Paclitaxel Injection Diluent with Two Reduced-Phthalate Administration Sets for the Acclaim Pump Page 2
Compatibility of Paclitaxel Injection Diluent with Two Reduced-Phthalate Administration Sets for the Acclaim Pump Page 3

Download in electronic PDF format for $75

Abstract:  The purpose of this project was to evaluate the compatibility of paclitaxel admixtures with the two reduced-phthalate administration sets designed for use with the Acclaim® Infusion Control Device. The first is a nitroglycerin set composed of polyethylene tubing, while the second is made using tris(2-ethylhexyl) trimellitate (TOTM)-plasticized polyvinyl chloride tubing. Both sets utilize a diethylhexyl phthalate (DEHP)- plasticized pumping segment. The potential for extraction of DEHP from the pumping segments and TOTM plasticizer from the plastic matrix by the Cremophor® EL surfactant present in the paclitaxel injection was evaluated.

Diethylhexyl phthalate and TOTM plasticizer extraction was tested using the paclitaxel diluent at concentrations equivalent to 0.3 and 1.2 mg/mL over three-hour and four-day infusions. All samples were prepared in triplicate in polyolefin bags of 5% dextrose injection and delivered through the administration sets into glass collection flasks. Both DEHP and TOTM content were determined using high-performance liquid chromatographic methods.

None of the admixtures delivered rapidly over three hours or slowly over four days through the TOTM-plasticized set exhibited any detectable TOTM. Similarly, no DEHP was detected in the effluent from either set with the simulated 0.3-mg/mL admixtures delivered over three hours. The simulated 1.2-mg/mL admixture delivered over three hours yielded only a barely detectable, but not quantifiable, trace of DEHP. However, slow delivery of both concentrations over four days through both sets resulted in leached DEHP in concentrations ranging from about 30 to 150 µg/mL at both one and four days.

The two reduced-phthalate administration sets tested in this study are suitable for the administration of paclitaxel infusions of short duration, for up to three hours. However, the sets cannot be recommended for administration over longerduration delivery times ranging from one to four days due to leaching of DEHP plasticizer from the pumping segments.

Related Keywords: cremaphor, diluent, hplc, paclitaxel, phthalate, taxol, trimellitate

Related Categories: CANCER AND AIDS, INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Compatibility of Paclitaxel Injection Diluent with Two Reduced-Phthalate Administration Sets for the Acclaim Pump
Xu Quanyun A
, Trissel Lawrence A
Sep/Oct 1998
Pg. 382-384

Stability of Carboplatin, Paclitaxel, and Docetaxel with Acetyl-L-carnitine During Simulated Y-site Administration
Zhang Yang
, Scarlett Cameron, Hutson Paul
Jan/Feb 2012
Pg. 82-85

Paclitaxel 6-mg/mL Injection
Allen Loyd V Jr
Mar/Apr 2013
Pg. 151

Zinc Content of Commercial Diluents Widely Use in Drug Admixtures Prepared for Intravenous Infusion
Desai Narendra R
, Shah Syed M, Koczone Julianna, Vencl-Joncic Maja, Sisto Christopher, Ludwig Stephen A
Sep/Oct 2007
Pg. 426-432

Basics of Compounding: Excipients Used in Nonsterile Compounding: Diluents
Allen Loyd V Jr
May/Jun 2021
Pg. 218-221

Paclitaxel Compatibility with IV Express Filter Unit
Xu Quanyun A
, Trissel Lawrence A, Zhang Yanping
May/Jun 1998
Pg. 243-245

Capsule and Tablet Diluents, Featured Excipient:
Allen Loyd V Jr
Jul/Aug 2000
Pg. 306-310

Compounding an Extended Stability Admixture of Paclitaxel for Long-Term Infusion
Trissel Lawrence A
, Xu Quanyun, Martinez Juan F
Jan/Feb 1997
Pg. 49-53

Jet Injection Devices for the Needle-free Administration of Compounds, Vaccines, and Other Agents
Logomasini Mark A
, Stout Richard R, Ron Marcinkoski
Jul/Aug 2013
Pg. 270-280

Drug Compatibility and Stability in Dextrose vs Saline
Newton David W
May/Jun 2011
Pg. 190-192

Compatibility Screening of Bivalirudin During Simulated Y-Site Administration with Other Drugs
Trissel Lawrence A
, Saenz Christopher
Jul/Aug 2002
Pg. 311-315

Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration
Trusley Craig
, Kupiec Thomas C, Trissel Lawrence A
May/Jun 2006
Pg. 230-233

Compatibility Screening of Hextend During Simulated Y-Site Administration with Other Drugs
Trissel Lawrence A
, Williams Kimberly Y, Baker Ma
Jan/Feb 2001
Pg. 69-73

Compatibility Screening of Precedex During Simulated Y-Site Administration with Other Drugs
Trissel Lawrence A
, Saenz Christopher, Williams Kimberly Y, Ingram Delshalonda S, Retzinger Julie P
May/Jun 2002
Pg. 230-233

Stability of Two Concentrations of Heparin Sodium Prefilled in CADD-Micro Pump Syringes
Stiles M Lou
, Allen Loyd V Jr, McLaury Hei-Jen
Nov/Dec 1997
Pg. 433-434

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Nov/Dec 2007
Pg. 520-524

Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration
Trusley Craig
, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008
Pg. 156-160

Compatibility and Stability of Palonosetron Hydrochloride with Gentamicin, Metronidazole, or Vancomycin During Simulated Y-Site Administration
Kupiec Thomas C
, Ben Michel, Trusley Craig, Trissel Lawrence A
Mar/Apr 2008
Pg. 170-173

Compatibility and Stability of Palonosetron Hydrochloride and Propofol During Simulated Y-Site Administration
Trissel Lawrence A
, Trusley Craig, Kupiec Thomas C, Ben Michel
Jan/Feb 2009
Pg. 78-80

Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration
Lu Juan
, Liu Qiang, Kupiec Thomas C, Vail Herbert, Lynch Leslie R, Fam David S, Vu Nicole T
Jan/Feb 2021
Pg. 52-61

Return to Top