Weight Uniformity of Scored Tablet Halves Manufactured by Palestinian Pharmaceutical Companies

Zaid, AN; Abu, Ghosh A; Kittana, N

Abstract

Weight Uniformity of Scored Tablet Halves Manufactured by Palestinian Pharmaceutical Companies

Author(s): Zaid AN, Abu Ghosh A, Kittana N

Issue: May/Jun 2010 - Pain Management

View All Articles in Issue

Page(s): 257-260

Download in electronic PDF format for $75

Abstract

The purpose of this study was to evaluate the weight uniformity of some commonly divided tablets produced by Palestinian Pharmaceutical companies. Volunteers were asked to divide scored tablets. The split units were individually weighed and the relative standard deviation for each product was calculated. Five scored tablet products failed the United States Pharmacopeia test of mass uniformity; this indicates that the splitting of these tablet products is not reliable for the provision of accurate doses. The practice of dividing tablets to achieve therapeutic and economic benefits for the patient may cause significant problems, especially in drugs with low therapeutic indices. Pharmacists may resolve this inconvenience by reformulating the tablet into a new dosage form, such as capsules, which should contain the exact amount of the medication.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
May/Jun 2010 Pg. 257-260	Weight Uniformity of Scored Tablet Halves Manufactured by Palestinian Pharmaceutical Companies Author(s): Zaid AN, Abu Ghosh A, Kittana N
Mar/Apr 2020 Pg. 92	PreScription: Formal Appeals to United States Pharmacopeia Regarding USP Chapters <795>,<797>, and <825>: Part 1 Author(s): Allen Loyd V Jr
May/Jun 2020 Pg. 180	PreScription: Formal Appeals to United States Pharmacopeia Regarding USP Chapters <795>, <797>, and <825>: Part 2 Author(s): Allen Loyd V Jr
May/Jun 2023 Pg. 240-249	An Alternative Approach to Tablet Splitting and Grinding for Medication Administration Author(s): Taneja Rajneesh, Scarim Joseph, Pande Poonam G, Scarim Anthony, Nahata Milap C, Jew Rita K, Inabathina Koteswara Rao
May/Jun 2019 Pg. 258-263	An Exploratory Study of Suboxone (Buprenorphine/Naloxone) Film Splitting: Cutting Methods, Content Uniformity, and Stability Author(s): Reindel Kristin L, DeAngelis Michael J, Ferrara Alexander S, Conn Kelly M, Phillips Elizabeth M, Corigliano Anthony T, Zhao Fang
Mar/Apr 2022 Pg. 163-174	Molding as Innovative Technology for Personalized Tablet Production Author(s): Mady Omar Y, Al-Shoubki Adam A, Hagag Youssef, Ibrahim Bakry, Donia Ahmed A
Mar/Apr 2021 Pg. 115-124	Quality Control: Minor Chapters, Major Impacts: What United States Pharmacopeia Chapters <51>, <61>, <62>, and <1207> Mean for Your Compounding Practice Author(s): Kelley Brian
Mar/Apr 2012 Pg. 146-150	Basics of Compounding: Implementing United States Pharmacopeia Chapter <1163> Quality Assurance in Pharmaceutical Compounding, Part 1 Author(s): Allen Loyd V Jr
May/Jun 2022 Pg. 255-263	Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Author(s): Liew Kai Bin, Hii Shou Hui, Chew Yik Ling, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam
Nov/Dec 2021 Pg. 491-496	Basics of Sterile Compounding: Intravenous Admixture Preparation, Part 12: United States Pharmacopeia Chapters Referenced in the Current United States Pharmacopeia Chapter <797> Pharmaceutical Compounding -- Sterile Preparations Author(s): Allen Loyd V Jr
Jan/Feb 2012 Pg. 64-68	Basics of Compounding: Implementing United States Pharmacopeia Chapter <795> Pharmaceutical Compounding–Nonsterile Preparations, Part 4 Author(s): Allen Loyd V Jr
Sep/Oct 2011 Pg. 408-414	Basics of Compounding: Implementing United States Pharmacopeia Chapter <795> Pharmaceutical Compounding--Nonsterile Preparations, Part 2 Author(s): Allen Loyd V Jr
Nov/Dec 2011 Pg. 488-496	Basics of Compounding: Implementing United States Pharmacopeia Chapter <795> Pharmaceutical Compounding--Nonsterile Preparations, Part 3 Author(s): Allen Loyd V Jr
May/Jun 2011 Pg. 224-232	Quality Control Analytical Methods: Aqua Pura: Water Purification Systems and United States Pharmacopeia Waters for the Compounding Pharmacy, Part 2: USP Waters: Experts at the United States Pharmacopeia Answer Compounders' Questions Author(s): Schnatz Rick, Hernandex-Cardoso Antonio
Jul/Aug 2011 Pg. 328-331	Basics of Compounding: Implementing United States Pharmacopeia Chapter <795> Pharmaceutical Compounding--Nonsterile Preparations, Part 1 Author(s): Allen Loyd V Jr
Jul/Aug 2007 Pg. 302-305	Update on the Proposed Revision Process for United States Pharmacopeia Chapter <797> Pharmaceutical Compounding--Sterile Preparations Author(s): Okeke Claudia C
Sep/Oct 2007 Pg. 404-410	Considerations for Implementing United States Pharmacopeia Chapter <797> Pharmaceutical Compounding--Sterile Preparations, Part 3: Risk Levels Author(s): Allen Loyd V Jr, Okeke Claudia C
Mar/Apr 2020 Pg. 148-155	Comparison of Disintegrant-addition Methods on the Compounding of Orodispersible Tablets Author(s): Mahesparan Vishnu A/L, Bin Abd Razak Fashli Syafiq, Ming Long Chiau, Uddin ABM Helal, Sarker Md Zaidul Islam, Bin Liew Kai
Sep/Oct 2013 Pg. 439	PostScription: GMPs vs. GCPs: United States Pharmacopeia General Chapters Author(s): Allen Loyd V Jr
Mar/Apr 2014 Pg. 101-111	Pharmaceutical Compounding or Pharmaceutical Manufacturing? A Regulatory Perspective Author(s): Timko Robert J, Crooker Philip EM