Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Molding as Innovative Technology for Personalized Tablet Production

Author(s):  Mady Omar Y, Al-Shoubki Adam A, Hagag Youssef, Ibrahim Bakry, Donia Ahmed A

Issue:  Mar/Apr 2022 - Volume 26, Number 2
View All Articles in Issue

Abstract:  The future of dosage form design is expected to move towards the production of personalized dosage forms tailored to each patient. The 3D printer was introduced to solve that problem but is not easy to use in a pharmacy. Herein, a new 3D mold technology is adopted for tablet manufacturing. Preparation of amlodipine tablets was used as a Biopharmaceutics Classification System Class 1 drug model to study this technology. Different concentrations of either starch or Avicel-based formulations and different concentrations of hydroxypropyl methylcellulose as a binder for mass formation were used. The mass formed for each formula was cast into the mold for tablet preparation. Different non-pharmacopeial and pharmacopeial quality-control tests of the prepared tablets by using the 3D mold were compared to a marketed tablet product of amlodipine. 3D-molded tablets showed compliance properties with the tablet pharmacopeial quality standard. Studying the equivalence of the 3D mold tablets to the brand marketed product under biowaiver conditions was carried out. The difference and similarity factors studies of molded tablets prepared using starch or Avicel as a filler and 2.5% of hydroxypropyl methylcellulose showed acceptable characters to the drug brand name. It is predicted that by using this simple technique, it would be possible to produce tablets with designed disintegration and release profiles, which could potentially allow the tailoring of the drug release and hence personalize the medicine for each patient. 

Related Keywords: Omar Y. Mady, Assistant Professor, Adam A. Al-Shoubki, PhD - Scholar, Youssef Hagag, PhD, Bakry Ibrahim, MSc - Scholar, Ahmed A. Donia, Assistant Professor, personalized dosage forms, 3-dimensional printing, 3D printing, 3D molding, 3D mold casting, amlodipine, hypertension, high blood pressure, angina, chest pain, coronary artery disease, disintegration time, drug release, personalized medicine, tablet splitting, excipients, content uniformity, tablet hardness, tablet friability, dissolution profile


Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Molding as Innovative Technology for Personalized Tablet Production Mady Omar Y, Al-Shoubki Adam A, Hagag Youssef, Ibrahim Bakry, Donia Ahmed A Mar/Apr 2022 163-174 Buy
Basics of Compounding: 3D Printing--Pharmacy Applications, Part 2 Allen Loyd V Jr May/Jun 2017 215-220 Buy
A Procedure for Tablet Production by Using the 3D Molding Technology and Powder Micromeritics Properties Mady Omar May/Jun 2022 195-200 Buy
Basics of Compounding: 3D Printing--Pharmacy Applications: Geometric Shape Effects on 3D Printing Allen Loyd V Jr Sep/Oct 2017 388-392 Buy
Basics of Compounding: 3D Printing: Pharmacy Applications, Part 3: Compounding, Formulation Considerations, and the Future Allen Loyd V Jr Jul/Aug 2017 293-298 Buy
Basics of Compounding: 3D Printing--Pharmacy Applications, Part 1 Allen Loyd V Jr Mar/Apr 2017 127-130 Buy
Comparing Suppository Mold Variability Which Can Lead to Dosage Errors for Suppositories Prepared with the Same or Different Molds Alexander Kenneth S, Baki Gabriella, Hart Christine, Hejduk Courtney, Chillas Stephanie Nov/Dec 2013 512-514 Buy
Comparison of Solvent Casting and Spray Casting Method on Compounding of an Orally Disintegrating Film Containing Amlodipine Besylate Ruslan Mohamad Fariz Haiqal, Janakiraman Ashok Kumar, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam, Bin Liew Kai Mar/Apr 2022 155-162 Buy
Advanced Compounding: Compounding with Microneedle Arrays, Part 3: Microneedle Array Development in the Literature and Quality Control of Microneedle Arrays Allen Loyd V Jr Jan/Feb 2023 30-37 Buy
Warfarin Personalized Dosage: Re-compounding for a More Suitable Therapy and Better Compliance Pellagatti Tommaso, Ternelli Marco, Frascio Davide, Bettini Ruggero May/Jun 2017 247-250 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions