Abstract

Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets

Author(s): Liew Kai Bin, Hii Shou Hui, Chew Yik Ling, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam

Issue: May/Jun 2022 - Volume 26, Number 3

Page(s): 255-263

Download in electronic PDF format for $75
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 1
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 2
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 3
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 4
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 5
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 6
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 7
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 8
  • Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets Page 9

Abstract

Co-processed excipients were prepared by incorporating one excipient into the particle structure of another and a combination of two or more compendia or noncompendia excipients to physically modify their properties, which cannot be achievable by simple physical mixing. The co-processed multicomponent-based excipients were introduced to achieve better characteristics and tableting properties. This objective of this study was to develop and evaluate a co-processed excipient for amlodipine orally disintegrating tablets to simplify the compounding process. The co-processed excipients were prepared by wet granulation with 5% of polyvinylpyrrolidone and croscarmellose sodium, five different percentages of microcrystalline cellulose, and lactose monohydrate. After sieving and drying, the co-processed excipients were evaluated for flowability and compressibility. The co-processed excipients were mixed with the amlodipine powder and magnesium stearate and compressed into tablets. The amlodipine tablets were evaluated for weight variation, content uniformity, thickness, hardness, friability, disintegration, and dissolution tests. Formulation 4 was chosen as the optimum formulation because the results showed this formulation had the excellent flowability and compressibility of a co-processed excipient. It showed uniformity of weight, content, thickness, and hardness, weight loss less than 1%, fast disintegration time, and dissolution results. The developed co-processed excipient can be used by the pharmaceutical industry in the future to compound amlodipine orally disintegrating tablets in a fast and economical way.

Related Keywords

  • co-processed excipients
  • orally disintegrating tablets
  • amlodipine
  • tablet compounding
  • literature review
  • polyvinylpyrrolidone
  • microcrystalline cellulose
  • croscarmellose sodium
  • powder flow
  • angle of repose
  • Hausner ratio
  • Carr Index
  • bulk powder density
  • tapped powder density
  • weight variation
  • content uniformity
  • stability
  • disintegration
  • dissolution
  • hardness
  • friability

Related Categories

  • EXCIPIENTS
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • DOSAGE FORMS/DRUG CARRIERS
  • LITERATURE REVIEW

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
May/Jun 2022
Pg. 255-263
Application of Co-processed Excipient as a Novel Method to Compound Orally Disintegrating Tablets
Author(s): Liew Kai Bin, Hii Shou Hui, Chew Yik Ling, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam
Nov/Dec 2023
Pg. 522-527
Development of a Novel Co-processed Excipitient Comprising of Xylitol, Mannitol, Microcrystalline Cellulose, and Crospovidone for the Compounding of Memantine Hydrochloride Orally Disintegrating Tablet
Author(s): Hazdi Siti Nursaqifah, Phang Hiu Ching, Ng Zhi Qi, Chew Yik Ling, Uddin ABM Helal, Sarker Zaidul Islam, Lee Siew-Keah, Liew Kai Bin
Jan/Feb 2022
Pg. 80-87
Investigation of the Effects of Excipients in the Compounding of Amlodipine Besylate Orally Disintegrating Tablets
Author(s): Azmi Nurual Hanisah Saiful, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam, Bin Liew Kai
Sep/Oct 2022
Pg. 370-377
Recent Formulation Advances and Preparation of Orally Disintegrating Tablets
Author(s): Ejeta Fikadu
Sep/Oct 2001
Pg. 389-390
Capsule and Tablet Disintegrating Agents, Featured Excipient:
Author(s): Allen Loyd V Jr
Nov/Dec 2020
Pg. 509-514
Investigation of Filler Effects on the Compounding of Freeze-dried Orodispersible Tablets Containing Annona muricata Extract
Author(s): Azman Syahiera Ezzah Noor, Abd Razak Fashli Syafiq, Kamal Wan Hamirul Bahrin Wan, Zheng Gan Kok, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam, Bin Liew Kai
Mar/Apr 2022
Pg. 155-162
Comparison of Solvent Casting and Spray Casting Method on Compounding of an Orally Disintegrating Film Containing Amlodipine Besylate
Author(s): Ruslan Mohamad Fariz Haiqal, Janakiraman Ashok Kumar, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam, Bin Liew Kai
Mar/Apr 2020
Pg. 148-155
Comparison of Disintegrant-addition Methods on the Compounding of Orodispersible Tablets
Author(s): Mahesparan Vishnu A/L, Bin Abd Razak Fashli Syafiq, Ming Long Chiau, Uddin ABM Helal, Sarker Md Zaidul Islam, Bin Liew Kai
May/Jun 2004
Pg. 181-185
Compounding in the Pharmacy Curriculum: Beyond the Basics
Author(s): Hinkle Amanda R, Newton Gail D
Mar/Apr 2022
Pg. 163-174
Molding as Innovative Technology for Personalized Tablet Production
Author(s): Mady Omar Y, Al-Shoubki Adam A, Hagag Youssef, Ibrahim Bakry, Donia Ahmed A
Jan/Feb 2015
Pg. 49-56
Basics of Sterile Compounding: Aseptic Processing
Author(s): Akers Michael J
Sep/Oct 2024
Pg. 402-407
Taste Masking Study of Orally Disintegrating Film (ODF) Formulations Containing Memantine Hydrochloride
Author(s): Gobal Ganesan, Phang Hiu Ching, Ng Zhi Qi, Loke Ying Hui, Chew Yik Ling, Uddin ABM Helal, Lee Siew-Keah, Lakshminarayanan Vijayakumar, Liew Kai Bin, Rahman Shamima Abdul
Sep/Oct 2024
Pg. 423-431
Comparison of Oven Dried and Freeze Dried Orally Disintegrating Film (ODF) Formulations Containing Memantine Hydrochloride
Author(s): Phang Hiu Ching, Tan Julia M, Subramaniam Poonguzhali, Uddin ABM Helal, Ee Mei Hooi, Lakshminarayanan Vijayakumar, Liew Kai Bin
Jul/Aug 2000
Pg. 306-310
Capsule and Tablet Diluents, Featured Excipient:
Author(s): Allen Loyd V Jr
May/Jun 2023
Pg. 240-249
An Alternative Approach to Tablet Splitting and Grinding for Medication Administration
Author(s): Taneja Rajneesh, Scarim Joseph, Pande Poonam G, Scarim Anthony, Nahata Milap C, Jew Rita K, Inabathina Koteswara Rao
Jul/Aug 2017
Pg. 293-298
Basics of Compounding: 3D Printing: Pharmacy Applications, Part 3: Compounding, Formulation Considerations, and the Future
Author(s): Allen Loyd V Jr
Sep/Oct 2023
Pg. 431-439
The Influence of Polymers, Surfactants, and Other Excipients on Naproxen Sodium Release from Matrices Prepared and the Effect of These Additives on the Swelling Rate of the Tablet
Author(s): Alhmoud Hassan, Akkam Yazan, Omari Derar, Alghananim Alaa, Melhem Mohammad Bani
Sep/Oct 2024
Pg. 432-439
Enhancing Hormonal Tablets Disintegration: The Role of Chitosan as an Alternative Disintegrant in Estradiol Tablet Formulation
Author(s): Sembiring Mikael Ham, Riadi Taufik, Arsyadi
Nov/Dec 2023
Pg. 512-521
Compounding and Characterization of Oral Disintegrating Films Containing Memantine Hydrochloride for Geriatrics
Author(s): Rofiq Hanifah Mohd, Phang Hiu Ching, Janakiraman Ashok Kumar, Chew Yik-Ling, Uddin ABM Helal, Sarker Zaidul Islam, Lee Siew-Keah, Liew Kai Bin
Jul/Aug 2016
Pg. 283-292
Choosing a Vial Processing Line for Aseptic Compounding: Part 1
Author(s): Noorian Shaun, Vahedi Navid