Abstract

N-acetylcysteine Used to Decrease the Incidence of Contrast-Induced Nephropathy Following Radiographic Procedures: A Literature Review

Author(s): McElhiney Linda F

Issue: Mar/Apr 2005 - Health and Wellness

Page(s): 99-103

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  • N-acetylcysteine Used to Decrease the Incidence of Contrast-Induced Nephropathy Following Radiographic Procedures: A Literature Review Page 1
  • N-acetylcysteine Used to Decrease the Incidence of Contrast-Induced Nephropathy Following Radiographic Procedures: A Literature Review Page 2
  • N-acetylcysteine Used to Decrease the Incidence of Contrast-Induced Nephropathy Following Radiographic Procedures: A Literature Review Page 3
  • N-acetylcysteine Used to Decrease the Incidence of Contrast-Induced Nephropathy Following Radiographic Procedures: A Literature Review Page 4
  • N-acetylcysteine Used to Decrease the Incidence of Contrast-Induced Nephropathy Following Radiographic Procedures: A Literature Review Page 5

Abstract

Contrast medium–induced nephropathy (CIN) is a preventable complication of administration of radiocontrast agents used in procedures such as cardiac catheterization. Hydration with 0.45% sodium chloride solution is the current standard for preventing CIN. Oral N-acetylcysteine, along with hydration with 0.45% sodium chloride solution, is gaining acceptance nationwide as a promising preventive protocol for CIN. N-acetylcysteine is well tolerated by patients: no major side effects have been reported. Compounding pharmacists can play an important role in preventing CIN by compounding N-acetylcysteine into a palatable capsule form that will improve patient compliance and by counseling patients on the importance of keeping hydrated prior to contrast medium procedures.

Related Keywords

  • N-acetylcysteine
  • radiographic procedures
  • cardiac catheterization
  • contrast medium
  • contrast-induced nephropathy
  • hydration
  • renal failure
  • kidney failure

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