Abstract

Contrast medium–induced nephropathy (CIN) is a preventable complication of administration of radiocontrast agents used in procedures such as cardiac catheterization. Hydration with 0.45% sodium chloride solution is the current standard for preventing CIN. Oral N-acetylcysteine, along with hydration with 0.45% sodium chloride solution, is gaining acceptance nationwide as a promising preventive protocol for CIN. N-acetylcysteine is well tolerated by patients: no major side effects have been reported. Compounding pharmacists can play an important role in preventing CIN by compounding N-acetylcysteine into a palatable capsule form that will improve patient compliance and by counseling patients on the importance of keeping hydrated prior to contrast medium procedures.

Related Keywords

• N-acetylcysteine
• radiographic procedures
• cardiac catheterization
• contrast medium
• contrast-induced nephropathy
• hydration
• renal failure
• kidney failure