Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Chemical Stability of Naltrexone Hydrochloride Injection

Author(s):  Gupta Vishnu D

Issue:  May/Jun 2008 - Pain Management
View All Articles in Issue

Page(s):  274-275

Chemical Stability of Naltrexone Hydrochloride Injection Page 1
Chemical Stability of Naltrexone Hydrochloride Injection Page 2

Download in electronic PDF format for $75

Abstract:  The chemical stability of naltrexone hydrochloride injection was studied by using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug were related directly to peak heights, and the percent relative standard deviation based on five injections was 1.0. The products of decomposition and excipients present in the dosage form did not interfere with the developed assay method. The injection was stable for at least 42 days when stored in clear glass vials at room temperature. The pH value of the injection decreased from 6.4 to 5.5 after 42 days of storage; the physical appearance of the injection did not change during the study period.

Related Keywords: naltrexone hydrochloride, stability, opiate addiction, storage

Related Categories: PARENTERALS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, NEUROLOGY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Chemical Stability of Naltrexone Hydrochloride Injection
Gupta Vishnu D
May/Jun 2008
Pg. 274-275

Physicochemical Stability of Compounded Naltrexone Hydrochloride Solutions in PCCA Base SuspendIt
Pramar Yashoda V
, Mandal Tarun K, Bostanian Levon A, Nguyen Anh TQ, Morris Tommy C, Graves Richard A
Mar/Apr 2019
Pg. 157-162

Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes
Xu Quanyun A
, Trissel Lawrence A, Pham Lien
Jan/Feb 2002
Pg. 66-69

Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes
Trissel Lawrence A
, Xu Quanyun A, Pham Lien
Jan/Feb 2002
Pg. 70-73

Naltrexone Hydrochloride 1.4-mg/mL Injection, Preservative Free
Allen Loyd V Jr
Jan/Feb 2005
Pg. 67

Physical and Chemical Stability of Hydromorphone Hydrochloride 1.5- and 80-mg/mL Packaged in Plastic Syringes
Trissel Lawrence A
, Xu Quanyun A, Pham Lien
Jan/Feb 2002
Pg. 74-76

Naltrexone Hydrochloride 50-mg Capsules
Allen Loyd V Jr
May/Jun 2013
Pg. 235

Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration
Trissel Lawrence A
, Xu Quanyun A
May/Jun 2005
Pg. 238-241

Naltrexone Hydrochloride 0.5 mg/mL and 5.0 mg/mL in SuspendIt Suspension
Allen Loyd V Jr
May/Jun 2021
Pg. 233

Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride
Alexander Kenneth S
, Thyangarajapuram N
Sep/Oct 2003
Pg. 389-393

Chemical Stability of Tramadol Hydrochloride Injection
Gupta Vishnu D
Mar/Apr 2008
Pg. 161-162

Naltrexone 1-mg/mL Oral Liquid
Allen Loyd V Jr
Nov/Dec 2006
Pg. 459

Chemical Stability of Pyridoxine Hydrochloride 100-mg/mL Injection, Preservative Free
Gupta Vishnu D
Jul/Aug 2006
Pg. 318-319

Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Polonini Hudson
, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
Nov/Dec 2018
Pg. 516-526

Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis: A Case Report
Muller George
, Grieshaber Robert, Talley J Floyd, Riepl Mike, Fellows Don
Jul/Aug 2018
Pg. 270-278

Stability of Azathioprine, Clonidine Hydrochloride, Clopidogrel Bisulfate, Ethambutol Hydrochloride, Griseofulvin, Hydralazine Hydrochloride, Nitrofurantoin, and Thioguanine Oral Suspensions Compounded with SyrSpend SF pH4
Polonini Hudson
, Loures da Silva Sharlene, Neves Cunha Carolina, de Oliveira Ferreira Anderson, Anagnostou Korina, Dijkers Eli
May/Jun 2020
Pg. 252-262

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Sep/Oct 2002
Pg. 388-390

Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
Sep/Oct 2009
Pg. 445-446

Chemical Stability of Hydromorphone Hydrochloride in Patient-Controlled Analgesia Injector
Khondkar Dristi
, Chopra Poonam, McArter John P, Rosen Joseph A, Li S Kevin
Mar/Apr 2010
Pg. 160-164

Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs.
Xu Quanyun A
, Trissel Lawrence A, Pham Lien
May/Jun 2004
Pg. 228-230

Return to Top