Abstract

Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms

Author(s): Gupta Vishnu D

Issue: Sep/Oct 2009 - Veterinary Compounding

Page(s): 445-446

Download in electronic PDF format for $75
  • Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms Page 1
  • Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms Page 2

Abstract

The chemical stability of amitriptyline hydrochloride in two oral liquid dosage forms has been studied using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug were directly related to peak heights, with an R value of 0.999. The percent relative standard deviation based on five injections was 1.0. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The formulation which contained edetate disodium was stable for at least 37 days when stored in amber-colored glass bottles at room temperature. However, the pH value of this formulation decreased from 5.0 to 4.0 after 37 days of storage. The formulation without edetate disodium was stable for only 21 days (borderline) under the same storage conditions. The pH value of this formulation remained constant at 5 after 37 days of storage at room temperature, and the physical appearance of both formulations

Related Keywords

  • amitriptyline hydrochloride
  • antidepressant
  • stability
  • oral liquids
  • edetate disodium
  • leaching
  • storage containers

Related Categories

  • MENTAL HEALTH
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • NEUROLOGY

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Sep/Oct 2009
Pg. 445-446
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Author(s): Gupta Vishnu D
Jul/Aug 2022
Pg. 342-351
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt
Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Jul/Aug 2007
Pg. 347-348
Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form
Author(s): Gupta Vishnu D
Mar/Apr 2005
Pg. 165-166
Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Author(s): Gupta Vishnu D, Sood Arun
Jul/Aug 2008
Pg. 372-374
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Author(s): Gupta Vishnu D
Mar/Apr 2016
Pg. 164-166
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures
Author(s): Nahata Milap C
Sep/Oct 2003
Pg. 386-388
Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Author(s): Gupta Vishnu D
Nov/Dec 2018
Pg. 516-526
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Author(s): Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
May/Jun 2007
Pg. 259-261
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Author(s): Gupta Vishnu D
Nov/Dec 2005
Pg. 484-486
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms
Author(s): Gupta Vishnu D
Jan/Feb 2011
Pg. 78-80
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Author(s): Gupta Vishnu D, Gupta Vikas S
Sep/Oct 2016
Pg. 426-434
Stability of Allopurinol, Amitriptyline Hydrochloride, Carbamazepine, Domperidone, Isoniazid, Ketoconazole, Lisinopril, Naproxen, Paracetamol (Acetaminophen), and Sertraline Hydrochloride in SyrSpend SF PH4 Oral Suspensions
Author(s): Polonini Hudson C, Loures Sharlene, de Araujo Edson Peter, Brandão Marcos Antônio F, Ferreira Anderson O
Jan/Feb 2002
Pg. 66-69
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes
Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Jan/Feb 2002
Pg. 70-73
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes
Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
Nov/Dec 2010
Pg. 512
Amitriptyline Hydrochloride 2%, Baclofen 5%, Ketamine Hydrochloride 5%, Ketoprofen 10% in Pluronic Lecithin Organogel
Author(s): Allen Loyd V Jr
Jul/Aug 2024
Pg. 334-343
Physicochemical and Microbiological Stability of Compounded Clonidine Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt®
Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Johnson Jyra, Graves Richard A
Mar/Apr 2019
Pg. 157-162
Physicochemical Stability of Compounded Naltrexone Hydrochloride Solutions in PCCA Base SuspendIt
Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Nguyen Anh TQ, Morris Tommy C, Graves Richard A
Sep/Oct 2015
Pg. 428-431
Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Author(s): Nahata Milap C
Mar/Apr 2016
Pg. 159-163
Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups
Author(s): Kirk Loren, Lewis Paul, Luu Yao, Brown Stacy
May/Jun 2020
Pg. 252-262
Stability of Azathioprine, Clonidine Hydrochloride, Clopidogrel Bisulfate, Ethambutol Hydrochloride, Griseofulvin, Hydralazine Hydrochloride, Nitrofurantoin, and Thioguanine Oral Suspensions Compounded with SyrSpend SF pH4
Author(s): Polonini Hudson, Loures da Silva Sharlene, Neves Cunha Carolina, de Oliveira Ferreira Anderson, Anagnostou Korina, Dijkers Eli