Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Preoperative Cataract Surgery Gel in Polycarbonate Syringes

Author(s):  Bailey Caroline, Aloumanis Vasileios, Walker Brian, Ben Michel, McGuire Jason, Vu Nicole

Issue:  Nov/Dec 2009 - Geriatric Compounding
View All Articles in Issue

Page(s):  564-568

Download in electronic PDF format for $65

Abstract:  The stability of preoperative cataract surgery gel packaged in 1-mL polycarbonate syringes, stored protected from light under controlled temperatures for a period of 60 days, was studied. Preoperative cataract surgery gel is a mixture of cyclopentolate hydrochloride 0.51 mg/mL, phenylephrine hydrochloride 5.1 mg/mL, and tropicamide 0.51 mg/mL in preservative-free lidocaine hydrochloride 2% gel. Stability was defined as the maintenance of initial physical and chemical characteristics during storage under controlled ambient (25°C/60% relative humidity) or refrigerated (2°C to 4°C) conditions. Evaluation parameters were appearance, pH, sterility, endotoxin level, and potency of each active ingredient. The specificity and stability-indicating characteristics of an assay method using high-performance liquid chromatography were validated through forced degradation studies. Samples were tested at predefined time intervals over a period of 60 days. Preoperative cataract surgery gel maintained the appearance of a clea

Related Keywords: Caroline Bailey, MSc, RPh, Vasileios Aloumanis, MSFS, Brian Walker, Michel Ben, MS, Jason McGuire, BS, Nicole Vu, PhD, preoperative cataract surgery gel, cyclopentolate hydrochloride, phenylephrine hydrochloride, tropicamide, lidocaine hydrochloride gel, eye disorders, ocular surgery, ophthalmic preparations, anticholinergic agents, sympathetic agonists, local anesthetics, pupil dilation, mydriatics, sympathomimetics, stability, cycloplegics

Related Categories: OPHTHALMICS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS, DOSAGE FORMS/DRUG CARRIERS, STORAGE

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Stability of Preoperative Cataract Surgery Gel in Polycarbonate Syringes
Bailey Caroline
, Aloumanis Vasileios, Walker Brian, Ben Michel, McGuire Jason, Vu Nicole
Nov/Dec 2009
Pg. 564-568

Cyclopentolate Hydrochloride 0.5%, Phenylephrine HCl 2.5%, and Tropicamide 0.5% Ophthalmic Solution
Allen Loyd V Jr
Jul/Aug 2021
Pg. 324

Cyclopentolate Hydrochloride 0.2% and Phenylephrine Hydrochloride 1% Ophthalmic Solution
Allen Loyd V Jr
Nov/Dec 2013
Pg. 502

Compatibility and Stability of Palonosetron Hydrochloride with Gentamicin, Metronidazole, or Vancomycin During Simulated Y-Site Administration
Kupiec Thomas C
, Ben Michel, Trusley Craig, Trissel Lawrence A
Mar/Apr 2008
Pg. 170-173

Compatibility and Stability of Palonosetron Hydrochloride and Propofol During Simulated Y-Site Administration
Trissel Lawrence A
, Trusley Craig, Kupiec Thomas C, Ben Michel
Jan/Feb 2009
Pg. 78-80

Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel
Dahal Amit
, Neupane Rabin, Boddu Sai HS, Renukuntla Jwala, Khupse Rahul, Dudley Richard
Mar/Apr 2020
Pg. 168-175

Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Polonini Hudson
, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
Nov/Dec 2018
Pg. 516-526

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Nov/Dec 2007
Pg. 520-524

Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration
Trusley Craig
, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Mar/Apr 2008
Pg. 156-160

Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jul/Aug 2008
Pg. 368-371

Particle Measuring Systems - USP <797> Environmental Monitoring Solutions