Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Measurement of Free Iodine in Different Formulations of Povidone-Iodine Eye Drops 5%

Author(s):  Berisa Prado Silvia, Riestra Ayora Ana Cristina, Trelles Campa Adrián

Issue:  Sep/Oct 2019 - Volume 23, Number 5
View All Articles in Issue

Abstract:  There are multiple studies in the literature that support the use of povidone iodine in the preparation of the surgical field of cataract as the most effective means to reduce the bacteria present in the ocular surface and the risk of infection. The concentration of free iodine is related to the antiseptic activity of these compounds, being, therefore, a good indicator of its effectiveness. The objective of this study was to determine the amount of free iodine and the evolution of it in different formulations of povidone iodine eye drops. The povidone iodine 5% eye drops were prepared starting from Betadine 10% dermal or the active principle and using a solvent, phosphate-citrate buffer solution, and sodium chloride 0.9% or sterile water for injection. Aliquots of 5 mL were packed in low-absorption absorption eye drops, topaz glass vials, and polyethylene syringe. The determination of free iodine was made by volumetric titration. Titration was performed with 0.1 M sodium thiosulfate using a starch solution as an indicator. Of the 0.1 M sodium thiosulfate, 1 mL is equivalent to 12.69 mg of available iodine, and it is expressed as a percentage of free iodine in the iodized povidone (% free iodine). Eyewash titrations were performed by replacing the substance with 5 mL of eye drops and following the remaining steps. Valuations were made on days 0, 7, and 14, as well as the measurement of pH and osmolarity. The results show that there are no differences between the average results at the three measurements taken on days 0, 7, and 14. We conclude that the free iodine remains stable during the stability period of 14 days. Regarding the pH and osmolarity data, the authors believe that the best tolerated formula will be that elaborated with povidone iodine and a phosphate- citrate buffer solution.

Related Keywords: Silvia Berisa Prado, Pharm, Ana Cristina Riestra Ayora, Pharm, Adrián Trelles Campa, BSc, povidone-iodine eye drops, ophthalmologic surgery, complications, postoperative endophthalmitis, visual acuity, retinal detachment, eye injury, surgical field preparation, cataract surgery, ocular surface microbes, antiseptic agent, prophylaxis, solvents, free iodine, osmolarity, physical stability, chemical stability, storage containers, phosphate-citrate buffer solution


Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Measurement of Free Iodine in Different Formulations of Povidone-Iodine Eye Drops 5% Berisa Prado Silvia, Riestra Ayora Ana Cristina, Trelles Campa Adrián Sep/Oct 2019 418-421 Buy
Autologous Eye Drops for the Treatment of Dry Eye and Neurotrophic Keratitis Mixon William, Angelle Patricea (Patsy), Chang Richard I Nov/Dec 2009 506-515 Buy
Quality-Control Analytical Methods: Applications and Sterility of Autologous Eye Drops Reed-Kane Dana, Carlson Rachel A, Kupiec Thomas C, Vu Nicole Nov/Dec 2009 540-543 Buy
Stability and In Vitro Toxicity of an Infliximab Eye Drop Formulation Robert Marie-Claude, Spurr-Michaud Sandra, Frenette Mathieu, Young David, Gipson Ilene K, Dohlman Claes H Sep/Oct 2014 418-426 Buy
Protocol of Blood Serum Eye Drops Katsakoulas Ioannis, Lougovoi Claudia, Paraskevopoulou Penelope, Vougioukas Nikolaos May/Jun 2015 252-260 Buy
Simple Preparation of Timolol 0.5% Gel from Eye Drop Solution for Superficial Infantile Hemangiomas Choo Winnie Jul/Aug 2017 282-289 Buy
Long-term Stability of Epitheliotropic Factors in Frozen Serum Eye Drops Sahyoun Jean-Yves, Cloutier Marc, Frenette Mathieu, Robert Marie-Claude Jul/Aug 2022 336-341 Buy
Autologous Serum Eye Drops for Severe Dry Eye Syndrome in a Patient with Chronic Graft-vs-Host Disease: A Case Report Mixon Bill, Mixon Jan, Isbey Edward K III, Sprinkle Shari Sep/Oct 2014 370-377 Buy
Stability of Venlafaxine Immediate-Release Suspensions Donnelly Ronald F, Wong Keith, Goddard Rob, Johanson Christel Jan/Feb 2011 81-84 Buy
Povidone Iodine 10% Cold Sore Paint Allen Loyd V Jr Sep/Oct 2015 409 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions