Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Rifampin in SyrSpend SF

Author(s):  Sorenson Bridget, Whaley Paul

Issue:  Mar/Apr 2013 - Volume 17, Number 2
View All Articles in Issue

Abstract:  Rifampin is a bactericidal antibiotic drug of the rifamycin group. It is a semi-synthetic drug produced from the bacterium Streptomyces mediterranei. Rifampin is commonly manufactured in capsule, tablet, and syrup dosage forms. Some patients, however, cannot tolerate solid dosage forms or oral solutions containing alcohol or sorbitol. The objective of this study was to determine the stability of rifampin in SyrSpend SF. The studied samples were compounded into 25-mg/ml suspensions and stored in low-actinic bottles at room temperature and refrigerated conditions. Samples were assayed at each time point out to 60 days by a stability-indicating high-performance liquid chromatography method. The method was validated for its specificity through forced-degradation studies. The sample remained within 90% to 110% of the initial concentration throughout the course of the study. Based on data collected, the beyond-use date of the preparation is at least 60 days when refrigerated or stored at room temperature and protected from light.

Related Keywords: Bridget Sorenson, BS, CAPM, rifampin, rifamycin antibiotic, antimicrobial agent, excipients, stability, Paul Whaley, BS


Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Rifampin in SyrSpend SF Sorenson Bridget, Whaley Paul Mar/Apr 2013 162-164 Buy
Stability of Minoxidil in Espumil Foam Base Geiger Christine M, Sorenson Bridget, Whaley Paul A Mar/Apr 2013 165-167 Buy
Wetting and/or Solubilizing Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 2001 310-312 Buy
Stability of Captopril in SyrSPend SF Geiger Christine M, Sorenson Bridget, Whaley Paul A Jul/Aug 2013 336-338 Buy
Stability of Midazolam in SyrSpend SF and SyrSpend SF Cherry Geiger Christine M, Sorenson Bridget, Whaley Paul A Jul/Aug 2013 344-346 Buy
Stability Assessment of 10 Active Pharmaceutical Ingredients Compounded in SyrSpend SF Geiger Christine M, Sorenson Bridget, Whaley Paul Sep/Oct 2015 420-427 Buy
Stability of Omeprazole in SyrSpend SF Alka (Reconstituted) Whaley Paul A, Voudrie Mark A II, Sorenson Bridget Mar/Apr 2012 164-166 Buy
Physicochemical and Microbiological Stability of Vancomycin 10-mg/mL Intravitreal Syringes Bartoll Aaron Puplà, Bellés Medall Maria Dolores, Peñarrocha Josep Edo, Escrig Laura Solaz, Clemente Ruben Eguren, Azuara Julia Bodega, Piqueres Raul Ferrando Jul/Aug 2022 330-335 Buy
Stability of Gabapentin in SyrSpend SF Sorenson Bridget, Voudrie Mark A II, Gehrig Dan Jul/Aug 2012 347-349 Buy
Stability of Ursodiol in SyrSpend SF Cherry Flavored Geiger Christine M, Voudrie Mark A II, Sorenson Bridget Nov/Dec 2012 510-512 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions