Abstract

Stability of Rifampin in SyrSpend SF

Author(s): Sorenson Bridget, Whaley Paul

Issue: Mar/Apr 2013 - Volume 17, Number 2

Page(s): 162-164

Download in electronic PDF format for $75
  • Stability of Rifampin in SyrSpend SF Page 1
  • Stability of Rifampin in SyrSpend SF Page 2
  • Stability of Rifampin in SyrSpend SF Page 3

Abstract

Rifampin is a bactericidal antibiotic drug of the rifamycin group. It is a semi-synthetic drug produced from the bacterium Streptomyces mediterranei. Rifampin is commonly manufactured in capsule, tablet, and syrup dosage forms. Some patients, however, cannot tolerate solid dosage forms or oral solutions containing alcohol or sorbitol. The objective of this study was to determine the stability of rifampin in SyrSpend SF. The studied samples were compounded into 25-mg/ml suspensions and stored in low-actinic bottles at room temperature and refrigerated conditions. Samples were assayed at each time point out to 60 days by a stability-indicating high-performance liquid chromatography method. The method was validated for its specificity through forced-degradation studies. The sample remained within 90% to 110% of the initial concentration throughout the course of the study. Based on data collected, the beyond-use date of the preparation is at least 60 days when refrigerated or stored at room temperature and protected from light.

Related Keywords

  • rifampin
  • rifamycin antibiotic
  • antimicrobial agent
  • excipients
  • stability

Related Categories

  • EXCIPIENTS
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • INFECTIOUS DISEASE
  • STORAGE

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Mar/Apr 2013
Pg. 162-164
Stability of Rifampin in SyrSpend SF
Author(s): Sorenson Bridget, Whaley Paul
Jul/Aug 2001
Pg. 310-312
Wetting and/or Solubilizing Agents, Featured Excipient:
Author(s): Allen Loyd V Jr
Jul/Aug 2019
Pg. 319
Rifampin 25 mg/mL in SyrSpend SF Oral Suspension
Author(s): Allen Loyd V Jr
Jul/Aug 2013
Pg. 334
Rifampin 300-mg and Isoniazid 150-mg Capsules
Author(s): Allen Loyd V Jr
May/Jun 2010
Pg. 250-256
Compounding Rifampin Suspensions with Improved Injectability for Nasogastric Enteral Feeding Tube Administration
Author(s): de Villiers Melgardt M, Vogel Laura, Bogenschutz Monica C, Fingerhut Bonnie J, D'Silva Joseph B, Moore Anne
Jul/Aug 2023
Pg. 328
Rifampin 10-mg/mL Nasal Drops
Author(s): Allen Loyd V Jr
Jul/Aug 2020
Pg. 327-336
Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4
Author(s): Espana B, Joseph-Tornabène F, Jaquet Cécile, Perrot S, Prouillac C
Jul/Aug 2025
Pg. 319-327
Antimicrobial Effectiveness and Physicochemical Stability of Compounded Psychiatric and Neurological Drug Suspensions in SyrSpend® SF PH4
Author(s): Kegele Carolina Schettino, Dijkers Eli, Polonini Hudson
Sep/Oct 2015
Pg. 420-427
Stability Assessment of 10 Active Pharmaceutical Ingredients Compounded in SyrSpend SF
Author(s): Geiger Christine M, Sorenson Bridget, Whaley Paul
Jan/Feb 2010
Pg. 82-85
Stability of Oseltamivir Phosphate in SyrSpend SF, Cherry Syrup, and SyrSpend SF (For Reconstitution)
Author(s): Voudrie Mark A II, Allen D Brett
Jul/Aug 2013
Pg. 344-346
Stability of Midazolam in SyrSpend SF and SyrSpend SF Cherry
Author(s): Geiger Christine M, Sorenson Bridget, Whaley Paul A
Sep/Oct 2014
Pg. 427-431
Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition
Author(s): Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard
Nov/Dec 2008
Pg. 558-564
Stability of Metronidazole Benzoate in SyrSpend SF One-Step Suspension System
Author(s): Vu Nicole T, Aloumanis Vasileios, Ben Michel J, Kupiec Thomas C, Patterson Evelyn K, Radke Joshua, Erickson Martin A III, Schneider Gary
Jul/Aug 2012
Pg. 347-349
Stability of Gabapentin in SyrSpend SF
Author(s): Sorenson Bridget, Voudrie Mark A II, Gehrig Dan
Nov/Dec 2007
Pg. 520-524
Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jul/Aug 2010
Pg. 346-349
Compatibility and Stability of Cefotaxine, Vancomycin, and Ciprofloxacin in Antibiotic Lock Solutions Containing Heparin
Author(s): Baker Daniel S, Waldrop Bruce, Arnold John
Jul/Aug 2017
Pg. 301-308
Basics of Sterile Compounding: Excipients Used in Injections
Author(s): Akers Michael J
Jul/Aug 2017
Pg. 339-346
Stability of Acetazolamide, Baclofen, Dipyridamole, Mebeverine Hydrochloride, Propylthiouracil, Quinidine Sulfate, and Topiramate Oral Suspensions in SyrSpend SF PH4
Author(s): de Oliveira Ferreira Anderson, Polonini Hudson, Loures da Silva Sharlene, Buzinari Aglio Natália Cristina, Abreu Jordana, Fernandes Brandão Marcos Antônio
Jan/Feb 2020
Pg. 38-43
Basics: Excipients Used in Nonsterile Compounding, Part 4: Antioxidants and Chelating Agents
Author(s): Allen Loyd V Jr
May/Jun 2011
Pg. 255-258
Stability of Verapamil Hydrochloride in SyrSpend SF Compared to Sorbitol Containing Syrup and Suspending Vehicles
Author(s): Voudrie Mark A, Alexander Bridget, Allen D Brett