Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Sterile Filtration

Author(s):  Akers Michael J

Issue:  Sep/Oct 2015 - Volume 19, Number 5
View All Articles in Issue

Page(s):  393-401

Sterile Filtration Page 1
Sterile Filtration Page 2
Sterile Filtration Page 3
Sterile Filtration Page 4
Sterile Filtration Page 5
Sterile Filtration Page 6
Sterile Filtration Page 7
Sterile Filtration Page 8
Sterile Filtration Page 9

Download in electronic PDF format for $65

Abstract:  The great majority of sterile products commercially available as well as prepared in compounding pharmacies are sterilized by sterile filtration during aseptic processing. This brief and basic review will highlight the nature, action, and use of sterilizing filters. Special emphasis is given to how filters are validated in producing a sterile filtrate while being compatible with the filtered solution, as well as how filters are integrity tested during aseptic processing.

Related Keywords: Michael J. Akers, PhD, compounded sterile preparations, sterile filtration, particle filters, microfilters, ultrafilters, nanofilters, filter porosity, filter efficiency, filter material, filter membrane thickness, filter validation, bacterial retention destructive testing, in process filter integrity testing, bubble-point test, diffusion test, forward flow test, retention test apparatus, microbe contamination, microbial reduction, surface-active agents, amphiphilic wetting agents


Printer-Friendly Version

Related Articles from IJPC
(Click for Abstract / Details / Purchase)
Sterile Filtration
Akers Michael J
Sep/Oct 2015
Pg. 393-401

Compounding Enclosures: Ensuring Safety During the Preparation of Sterile and Nonsterile Formulations
Ashe Krystina
, Baskett Dustin
Sep/Oct 2018
Pg. 387-398

Basics of Sterile Compounding: Particulate Matter
Akers Michael J
Sep/Oct 2017
Pg. 395-404

Certification of Powder-containment Hoods for Nonsterile Compounding
Mulder Kyle
, Dozzi Raphael
Sep/Oct 2018
Pg. 369-384

Paclitaxel Compatibility with IV Express Filter Unit
Xu Quanyun A
, Trissel Lawrence A, Zhang Yanping
May/Jun 1998
Pg. 243-245

Sorption of Benzalkonium Chloride to Various Filters Used in Ophthalmics
Prince Shelly J
, Allen Loyd V Jr
May/Jun 1998
Pg. 249-251

Basics of Sterile Compounding: Aseptic Processing
Akers Michael J
Jan/Feb 2015
Pg. 49-56

Basics of Sterile Compounding: Bubble Point Testing
Thoma Laura
Jan/Feb 2014
Pg. 54-57

Pharmacy Compounding Urban Legends
Kastango Eric S
Jan/Feb 2006
Pg. 32-34

Accuracy Considerations in Sterile Compounding
Akers Michael J
Mar/Apr 2017
Pg. 133-142