Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Basics of Sterile Compounding: Manipulating Peptides and Proteins

Author(s):  Akers Michael J

Issue:  May/Jun 2017 - Volume 21, Number 3
View All Articles in Issue

Page(s):  223-228

Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 1
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 2
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 3
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 4
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 5
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 6

Download in electronic PDF format for $65

Abstract:  Biopharmaceuticals contain primary and secondary structure, which offer few problems. It is the tertiary structure that causes problems, resulting in both physical and chemical stability issues. The thrust of this article is to share briefly what can be done to minimize these problems.

Related Keywords: Michael J. Akers, PhD, compounded sterile preparations, sterile compounding, large molecules, peptides, proteins, monoclonal antibodies, biopharmaceutical active ingredients, physical stability, chemical stability, physical degradation, protein aggregation, hydrophobic interactions, denaturation, solubility, immunogenicity, protein adsorption, shaking, adverse shear effects, mixing, vortexing, low-shear mixers, order of mixing, filtration rate, filling rate, freeze drying, lyophilization, cryoprotectants, lyoprotectants, foreign particles, temperature controls, excess humidity, processing time, microbial contamination, storage containers

Related Categories: ENVIRONMENTAL , STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS, QUALITY CONTROL

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Basics of Sterile Compounding: Manipulating Peptides and Proteins
Akers Michael J
May/Jun 2017
Pg. 223-228

Formulation and Stability of Solutions
Akers Michael J
Jan/Feb 2016
Pg. 41-45

Formulation and Stability of Solutions
Akers Michael J
Mar/Apr 2016
Pg. 137-141

Investigation of the Physical, Chemical, and Microbiological Stability of Oral Solutions Compounded with Herbals
Khokhlova Kateryna O
, Zdoryk Oleksandr A
May/Jun 2018
Pg. 240-246

Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox)
Ip Kendice
, Carvalho Maria, Shan Ashley, Banov Daniel
Jul/Aug 2017
Pg. 322-329

Physical and Chemical Stability of Pharmaceutical Preparation of Bumetanide and Scopolamine
Catry Emilie
, Colsoul Marie-Louise, Closset Melanie, Hubert Justine, Soumoy Laura, Bihin Benoit, Thiry Emmanuell, Jamart Jacques, Hecq Jean-Daniel, Galanti Laurence
May/Jun 2022
Pg. 248-254

Basics of Sterile Compounding: Excipients Used in Injections
Akers Michael J
Jul/Aug 2017
Pg. 301-308

Basic Principles of Lyophilization, Part 1
Akers Michael J
Nov/Dec 2015
Pg. 471-476

Accuracy Considerations in Sterile Compounding
Akers Michael J
Mar/Apr 2017
Pg. 133-142

Physical-chemical Stability of Compounded Sildenafil 100-mg Rapid-dissolving Tablets
Cheung Matthew
, Zhao Fang, Dave Vivek S
Jan/Feb 2021
Pg. 82-87

Particle Measuring Systems - USP <797> Environmental Monitoring Solutions