Abstract

Basics of Sterile Compounding: Manipulating Peptides and Proteins

Author(s): Akers Michael J

Issue: May/Jun 2017 - Volume 21, Number 3

Page(s): 223-228

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Abstract

Biopharmaceuticals contain primary and secondary structure, which offer few problems. It is the tertiary structure that causes problems, resulting in both physical and chemical stability issues. The thrust of this article is to share briefly what can be done to minimize these problems.

Related Keywords

  • compounded sterile preparations
  • sterile compounding
  • large molecules
  • peptides
  • proteins
  • monoclonal antibodies
  • biopharmaceutical active ingredients
  • physical stability
  • chemical stability
  • physical degradation
  • protein aggregation
  • hydrophobic interactions
  • denaturation
  • solubility
  • immunogenicity
  • protein adsorption
  • shaking
  • adverse shear effects
  • mixing
  • vortexing
  • low-shear mixers
  • order of mixing
  • filtration rate
  • filling rate
  • freeze drying
  • lyophilization
  • cryoprotectants
  • lyoprotectants
  • foreign particles
  • temperature controls
  • excess humidity
  • processing time
  • microbial contamination
  • storage containers

Related Categories

  • ENVIRONMENTAL
  • STABILITIES, COMPATIBILITIES
  • STERILE PREPARATIONS
  • QUALITY CONTROL

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