Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Basics of Sterile Compounding: Manipulating Peptides and Proteins

Author(s):  Akers Michael J

Issue:  May/Jun 2017 - Volume 21, Number 3
View All Articles in Issue

Page(s):  223-228

Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 1
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 2
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 3
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 4
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 5
Basics of Sterile Compounding: Manipulating Peptides and Proteins Page 6

Download in electronic PDF format for $75

Abstract:  Biopharmaceuticals contain primary and secondary structure, which offer few problems. It is the tertiary structure that causes problems, resulting in both physical and chemical stability issues. The thrust of this article is to share briefly what can be done to minimize these problems.

Related Keywords: compounded sterile preparations, sterile compounding, large molecules, peptides, proteins, monoclonal antibodies, biopharmaceutical active ingredients, physical stability, chemical stability, physical degradation, protein aggregation, hydrophobic interactions, denaturation, solubility, immunogenicity, protein adsorption, shaking, adverse shear effects, mixing, vortexing, low-shear mixers, order of mixing, filtration rate, filling rate, freeze drying, lyophilization, cryoprotectants, lyoprotectants, foreign particles, temperature controls, excess humidity, processing time, microbial contamination, storage containers

Related Categories: ENVIRONMENTAL , STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS, QUALITY CONTROL

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Basics of Sterile Compounding: Manipulating Peptides and Proteins
Akers Michael J
May/Jun 2017
Pg. 223-228

Basics of Sterile Compounding: Sterile Basics of Compounding Intravenous Admixtures, Part 4: Physicochemical Considerations
Allen Loyd V Jr
Sep/Oct 2023
Pg. 397-409

Compounding in the Pharmacy Curriculum: Beyond the Basics
Hinkle Amanda R
, Newton Gail D
May/Jun 2004
Pg. 181-185

Overview of Chapter <797> "Pharmaceutical Compounding - Sterile Preparations": The Potential Impact for Compounding Pharmacists
Rahe Hank
Mar/Apr 2004
Pg. 89-94

Sterile Basics: Compounding Sterile Preparations with Cyclodextrins
Allen Loyd V Jr
Jan/Feb 2022
Pg. 41-49

Basics of Compounding for Sterile, Nonsterile, and Quality Control Compounding: Process Analytical Technology: Appropriate for Sterile and Nonsterile Compounding?
Allen Loyd V Jr
Mar/Apr 2019
Pg. 123-130

Sterile Basics: Pharmaceutical Waters Used in Sterile and Nonsterile Compounding
Allen Loyd V Jr
Sep/Oct 2019
Pg. 399-402

Formulation and Stability of Solutions
Akers Michael J
Jan/Feb 2016
Pg. 41-45

Sterile Basics of Compounding: Particulates in Parenteral Preparations: Sources, Minimization, and Detection
Allen Loyd V Jr
May/Jun 2022
Pg. 219-228

Basics of Sterile Compounding: Intravenous Admixture Preparation, Part 12: United States Pharmacopeia Chapters Referenced in the Current United States Pharmacopeia Chapter <797> Pharmaceutical Compounding -- Sterile Preparations
Allen Loyd V Jr
Nov/Dec 2021
Pg. 491-496

Basics of Compounding: Basics of Compounding with Complex Organic Molecules
Allen Loyd V Jr
May/Jun 2011
Pg. 234-238

Accuracy Considerations in Sterile Compounding
Akers Michael J
Mar/Apr 2017
Pg. 133-142

Basics of Sterile Compounding: Particulate Matter
Akers Michael J
Sep/Oct 2017
Pg. 395-404

The Role of Compounding in Closing Therapeutic Gaps--Abstracts from FIP 2013
Lutz Eugene
, Pauletti Giovanni, Carvalho Maria, Davidson Gigi, Ashworth Lisa, Subramaniam Vaiyapuri, LlambĂ­ Francesc
Jan/Feb 2014
Pg. 6-12

Basics of Sterile Compounding: Vehicles Used in Sterile Compounding
Allen Loyd V Jr
May/Jun 2019
Pg. 221-228

Basics of Sterile Compounding: Personnel Requirements for Sterile Compounding
Akers Michael J
Jul/Aug 2016
Pg. 307-314

Basics of Sterile Compounding: Sterile Product Packaging and Delivery Systems
Akers Michael J
Nov/Dec 2015
Pg. 491-500

Basics of Sterile Compounding: Sterilization Methods in Sterile Product Manufacturing
Akers Michael J
Mar/Apr 2015
Pg. 127-138

Basics of Sterile Compounding: Bubble Point Testing
Thoma Laura
Jan/Feb 2014
Pg. 54-57

Basics of Compounding: Considerations for Implementing USP Chapter <797> -- Sterile Preparations, Part 19: Storage and Beyond-Use Dating, Maintaining Sterility, Purity, and Stability of Dispensed and Distributed Compounded Sterile Preparations
Okeke Claudia C
, Allen Loyd V Jr
May/Jun 2010
Pg. 232-238

Return to Top