Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Sterile Filtration

Author(s):  Akers Michael J

Issue:  Mar/Apr 2024 - Volume 28, Number 2
View All Articles in Issue

Page(s):  120-127

Sterile Filtration Page 1
Sterile Filtration Page 2
Sterile Filtration Page 3
Sterile Filtration Page 4
Sterile Filtration Page 5
Sterile Filtration Page 6
Sterile Filtration Page 7
Sterile Filtration Page 8

Download in electronic PDF format for $75

Abstract:  The great majority of sterile products commercially available as well as prepared in compounding pharmacies are sterilized by sterile filtration during aseptic processing. This brief and basic review will highlight the nature, action, and use of sterilizing filters. Special emphasis is given to how filters are validated in producing a sterile filtrate while being compatible with the filtered solution, as well as how filters are integrity tested during aseptic processing.

Related Keywords: Michael J. Akers, PhD, compounded sterile preparations, sterile filtration, particle filters, microfilters, ultrafilters, nanofilters, filter porosity, filter efficiency, filter material, filter membrane thickness, filter validation, bacterial retention destructive testing, in process filter integrity testing, bubble-point test, diffusion test, forward flow test, retention test apparatus, microbe contamination, microbial reduction, surface-active agents, amphiphilic wetting agents


Printer-Friendly Version

Related Articles from IJPC
(Click for Abstract / Details / Purchase)
Sterile Filtration
Akers Michael J
Sep/Oct 2015
Pg. 393-401

Sterile Filtration
Akers Michael J
Mar/Apr 2024
Pg. 120-127

Compounding Enclosures: Ensuring Safety During the Preparation of Sterile and Nonsterile Formulations
Ashe Krystina
, Baskett Dustin
Sep/Oct 2018
Pg. 387-398

Basics of Sterile Compounding: Particulate Matter
Akers Michael J
Sep/Oct 2017
Pg. 395-404

Certification of Powder-containment Hoods for Nonsterile Compounding
Mulder Kyle
, Dozzi Raphael
Sep/Oct 2018
Pg. 369-384

Sterile Basics: Pharmaceutical Waters Used in Sterile and Nonsterile Compounding
Allen Loyd V Jr
Sep/Oct 2019
Pg. 399-402

Basics of Sterile Compounding: Bubble Point Testing
Thoma Laura
Jan/Feb 2014
Pg. 54-57

Paclitaxel Compatibility with IV Express Filter Unit
Xu Quanyun A
, Trissel Lawrence A, Zhang Yanping
May/Jun 1998
Pg. 243-245

Sorption of Benzalkonium Chloride to Various Filters Used in Ophthalmics
Prince Shelly J
, Allen Loyd V Jr
May/Jun 1998
Pg. 249-251

Basics of Sterile Compounding: Aseptic Processing
Akers Michael J
Jan/Feb 2015
Pg. 49-56

Accuracy Considerations in Sterile Compounding
Akers Michael J
Mar/Apr 2017
Pg. 133-142

Overview of Chapter <797> "Pharmaceutical Compounding - Sterile Preparations": The Potential Impact for Compounding Pharmacists
Rahe Hank
Mar/Apr 2004
Pg. 89-94

Basics of Sterile Compounding: Intravenous Admixture Preparation, Part 12: United States Pharmacopeia Chapters Referenced in the Current United States Pharmacopeia Chapter <797> Pharmaceutical Compounding -- Sterile Preparations
Allen Loyd V Jr
Nov/Dec 2021
Pg. 491-496

Basics of Sterile Compounding: Manipulating Peptides and Proteins
Akers Michael J
May/Jun 2017
Pg. 223-228

Basics of Sterile Compounding: Sterilization Methods in Sterile Product Manufacturing
Akers Michael J
Mar/Apr 2015
Pg. 127-138

Sterile Basics of Compounding: Particulates in Parenteral Preparations: Sources, Minimization, and Detection
Allen Loyd V Jr
May/Jun 2022
Pg. 219-228

Basics of Sterile Compounding: Personnel Requirements for Sterile Compounding
Akers Michael J
Jul/Aug 2016
Pg. 307-314

Basics of Sterile Compounding: Sterile Product Packaging and Delivery Systems
Akers Michael J
Nov/Dec 2015
Pg. 491-500

Adventures in the Environmental World and Environmental Microbiology Sampling of Air for Pharmaceutical Sterile Compounding
Ligugnana Roberto
May/Jun 2017
Pg. 182-190

Microbiologic Testing for 503A Sterile-Compounding Pharmacies
Mixon William
, Roth Abby
May/Jun 2017
Pg. 193-203

Return to Top