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Abstract:  Transdermal testosterone has been used for years to treat patients with low testosterone symptoms. Clinically, we have monitored patients to evaluate results of testosterone absorption via blood serum concentrations. The data on multiple time points to determine trough and peak concentrations is lacking in the literature. In this case study, we demonstrate the absorption of testosterone cream via scrotal delivery. The data suggests that after application therapeutic levels are reached with concentrations of (1204.7 ng/dL) within two hours. Additionally, consistent concentrations (1320.6 ng/dL) remain beyond six hours. To our knowledge, this is the first study to collect and measure multiple time points for testosterone via transdermal delivery. The research indicates that testosterone via transdermal delivery is an excellent method to achieve therapeutic concentrations of testosterone. Most importantly, the patient’s symptoms resolved without side effects.

Related Keywords: Shawn Needham, BS Pharmacy, RPh, Shane Needham, PhD Analytical Chemistry, testosterone cream, scrotal delivery, transdermal administration, case study, topical testosterone cream, low testosterone symptoms, decreased libido, erectile dysfunction, lethary, loss of lean body mass, weight gain

Related Categories: CASE REPORTS, DOSAGE FORMS/DRUG CARRIERS, ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE, UROLOGY/URINARY TRACT

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