Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

In Vitro Percutaneous Absorption of Ketoprofen and Testosterone: Comparison of Pluronic Lecithin Organogel vs. Pentravan Cream

Author(s):  Lehman Paul A, Raney Sam G

Issue:  May/Jun 2012 - Volume 16, Number 3
View All Articles in Issue

Abstract:  An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a Pluronic lecithin organogel and Pentravan Cream. Each formulation was applied to ex vivo human trunk skin (from three skin donors) on triplicate sections mounted onto Franz Diffusion Cells. Following a 5-mcL/cm2 applied dose, serial dermal receptor solutions were collected over 48 hours. For both compounds, a greater rate and extent of absorption was found from the Pentravan formulation than from the Pluronic lecithin organogel formulation: 3.8-fold greater for ketoprofen, 1.7-fold greater for testosterone, for amount absorbed.

Related Keywords: Paul A. Lehman, MSc, Sam G. Raney, PhD, percutaneous absorption, topical preparations, ketoprofen, testosterone, Pluronic lecithin organogel, Pentravan cream

Related Categories: EXCIPIENTS, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version




Download in electronic PDF format for $35

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
In Vitro Percutaneous Absorption of Ketoprofen and Testosterone: Comparison of Pluronic Lecithin Organogel vs. Pentravan Cream Lehman Paul A, Raney Sam G May/Jun 2012 248-252 Buy
Evaluation of Percutaneous Absorption Performance for Human Female Sexual Steroids into Pentravan Cream Polonini Hudson C, Brandão Marcos Antônio F, Ferreira Anderson O, Ramos Cristiano, Raposo Nádia R B Jul/Aug 2014 332-340 Buy
Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth May/Jun 2014 256-261 Buy
Evaluation of the Percutaneous Absorption of Promethazine Hydrochloride, In Vitro, Using the Human Ex Vivo Skin Model Bassani August S, Banov Daniel, Lehman Paul A May/Jun 2008 270-273 Buy
Bioavailability of Promethazine in a Topical Pluronic Lecithin Organogel: A Pilot Study Glisson James K, Wood Rebecca L, Kyle Patrick B, Cleary John D May/Jun 2005 242-246 Buy
Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel Dahal Amit, Neupane Rabin, Boddu Sai HS, Renukuntla Jwala, Khupse Rahul, Dudley Richard Mar/Apr 2020 168-175 Buy
Case Study: Absorption of Testosterone Cream via Scrotal Delivery Needham Shawn, Needham Shane Nov/Dec 2018 466-468 Buy
Effect of Formulation pH on Transdermal Penetration of Antiemetics Formulated in Poloxamer Lecithin Organogel Woodall Rachel, Arnold John J, McKay Doug, Abill C Scott May/Jun 2013 247-253 Buy
Baclofen 5%, Capcaicin 0.075%, Ketoprofen 10%, and Tetracaine 2% in Pluronic Lecithin Organogel Allen Loyd V Jr Nov/Dec 2010 513 Buy
Baclofen 5%, Gabapentin 5%, Ketoprofen 10%, and Lidocaine 5% in Pluronic Lecithin Organogel Allen Loyd V Jr Nov/Dec 2010 514 Buy