In Vitro Percutaneous Absorption of Ketoprofen and Testosterone: Comparison of Pluronic Lecithin Organogel vs. Pentravan Cream
Download in electronic PDF format for $75
Abstract: An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a Pluronic lecithin organogel and Pentravan Cream. Each formulation was applied to ex vivo human trunk skin (from three skin donors) on triplicate sections mounted onto Franz Diffusion Cells. Following a 5-mcL/cm2 applied dose, serial dermal receptor solutions were collected over 48 hours. For both compounds, a greater rate and extent of absorption was found from the Pentravan formulation than from the Pluronic lecithin organogel formulation: 3.8-fold greater for ketoprofen, 1.7-fold greater for testosterone, for amount absorbed.
Related Keywords:
percutaneous absorption, topical preparations, ketoprofen, testosterone, Pluronic lecithin organogel, Pentravan cream
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
In Vitro Percutaneous Absorption of Ketoprofen and Testosterone: Comparison of Pluronic Lecithin Organogel vs. Pentravan Cream
Lehman Paul A, Raney Sam G
|
May/Jun 2012
Pg. 248-252
|
Evaluation of Percutaneous Absorption Performance for Human Female Sexual Steroids into Pentravan Cream
Polonini Hudson C, Brandão Marcos Antônio F, Ferreira Anderson O, Ramos Cristiano, Raposo Nádia R B
|
Jul/Aug 2014
Pg. 332-340
|
Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery
Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth
|
May/Jun 2014
Pg. 256-261
|
Case Study: Absorption of Testosterone Cream via Scrotal Delivery
Needham Shawn, Needham Shane
|
Nov/Dec 2018
Pg. 466-468
|
Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison of Versatile Cream vs. Reference Cream
Wang Xuexuan, Black Laura
|
Nov/Dec 2013
Pg. 520-525
|
In Vitro Release Tests of Ketoprofen from Pluronic Lecithin Organogel versus Lipoderm Using Immersion Cells and the Phoenix DB-6 Dry Heat Diffusion Tester
McKinney Rachael D, Dunbar Jacob R
|
May/Jun 2021
Pg. 241-245
|
Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel
Dahal Amit, Neupane Rabin, Boddu Sai HS, Renukuntla Jwala, Khupse Rahul, Dudley Richard
|
Mar/Apr 2020
Pg. 168-175
|
Bioavailability of Promethazine in a Topical Pluronic Lecithin Organogel: A Pilot Study
Glisson James K, Wood Rebecca L, Kyle Patrick B, Cleary John D
|
May/Jun 2005
Pg. 242-246
|
Baclofen 5%, Capcaicin 0.075%, Ketoprofen 10%, and Tetracaine 2% in Pluronic Lecithin Organogel
Allen Loyd V Jr
|
Nov/Dec 2010
Pg. 513
|
Baclofen 5%, Gabapentin 5%, Ketoprofen 10%, and Lidocaine 5% in Pluronic Lecithin Organogel
Allen Loyd V Jr
|
Nov/Dec 2010
Pg. 514
|
Amitriptyline Hydrochloride 2%, Baclofen 5%, Ketamine Hydrochloride 5%, Ketoprofen 10% in Pluronic Lecithin Organogel
Allen Loyd V Jr
|
Nov/Dec 2010
Pg. 512
|
Ketoprofen 10% in Pluronic Lecithin Organogel
Allen Loyd V Jr
|
Mar/Apr 2019
Pg. 150
|
Physical Stability and Release Profile of Compounded Gabapentin Containing Pluronic Lecithin Organogel for Neuropathic Pain Management
Hong Eun Ji, Sumanasekera Wasana, Le Uyen Minh
|
Jan/Feb 2022
Pg. 65-71
|
Ketoprofen 10% in Pluronic Lecithin Organogel
Allen Loyd V Jr
|
Jul/Aug 2018
Pg. 319
|
Ketoprofen 10% in Pluronic Lecithin Organogel
Allen Loyd V Jr
|
Jan/Feb 2019
Pg. 52
|
Ketoprofen 10%, Ibuprofen 10%, Cyclobenzaprine Hydrochloride 2%, and Piroxicam 2% in Pluronic Lecithin Organogel Gel
Allen Loyd V Jr
|
May/Jun 2011
Pg. 245
|
The History of Pluronic Lecithin Organogel: An Interview With Marty Jones, BSPharm, FACA, FIACP
Allen Loyd V Jr
|
May/Jun 2003
Pg. 180-183
|
Considerations for Percutaneous Absorption
Newton Stephen J, Cook Jennifer M
|
Jul/Aug 2010
Pg. 301-304
|
Effect of Formulation pH on Transdermal Penetration of Antiemetics Formulated in Poloxamer Lecithin Organogel
Woodall Rachel, Arnold John J, McKay Doug, Abill C Scott
|
May/Jun 2013
Pg. 247-253
|
BHR in PLO Gel (Benadryl, Haldol, and Reglan in Pluronic Lecithin Organogel)
Allen Loyd V Jr
|
Jul/Aug 2021
Pg. 322
|
| Return to Top |
