Abstract

Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit

Author(s): Lardinois Benjamin, Dimitriou Alexandre, Delcave Charlotte, Soumoy Laura, Jamart Jacques, Bihin Benoît, Hecq Jean-Daniel, Galanti Laurence M

Issue: Jan/Feb 2020 - Volume 24, Number 1

Page(s): 64-68

Download in electronic PDF format for $75
  • Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit Page 1
  • Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit Page 2
  • Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit Page 3
  • Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit Page 4
  • Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit Page 5

Abstract

In order to avoid fluid overload, more concentrated drug solutions in intensive care units are commonly used. This study evaluated the physicochemical stability of concentrated solution of isosorbide dinitrate in polypropylene syringes during 28 days at 5°C ± 3°C with protection from light. Five syringes of 50 mL, containing 0.60 mg/mL of isosorbide dinitrate in sodium chloride 0.9% were prepared and stored at 5°C ± 3°C with protection from light during 28 days. Immediately after preparation and periodically during the storage, isosorbide dinitrate concentration was measured by an ultra-performance liquid chromatography. Spectrophotometric absorbance at different wavelengths, pH measurements, and microscopic observations were also performed. All solutions were physicochemically stable during the whole period storage at 5°C ± 3°C. No color change, turbidity, precipitation or opacity, significant pH variations, or optic densities were observed in the solutions. Any crystals were seen by microscopic analysis. The concentration of isosorbide dinitrate remained above 90% of the initial concentration during the 28 days of storage. Solutions of isosorbide dinitrate 0.60 mg/mL in syringe of sodium chloride 0.9 % injection can be considered physically and chemically stable for 28 days when stored in syringes at 5°C ± 3°C with protection from light and may be prepared in advance by a centralized intravenous additive service.

Related Keywords

  • concentration solutions
  • isosorbide dinitrate
  • vasodilation
  • left ventricular failure
  • unstable angina pectoris
  • acutely decompensated heart failure
  • fluid overload
  • drug stability
  • physical stability
  • chemical stability
  • centralized preparation
  • intravenous administration

Related Categories

  • PACKAGING
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • CARDIOLOGY

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Jan/Feb 2020
Pg. 64-68
Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit
Author(s): Lardinois Benjamin, Dimitriou Alexandre, Delcave Charlotte, Soumoy Laura, Jamart Jacques, Bihin Benoît, Hecq Jean-Daniel, Galanti Laurence M
Jul/Aug 2002
Pg. 255-256
Aminophylline 3%, Co-dergocrine Mesylate 0.05%, and Isosorbide Dinitrate 0.25% Cream for the Treatment of Orgasmic Dysfunction in Women
Author(s): Mason Dave
Jul/Aug 2018
Pg. 335-339
Long-term Physicochemical Stability of Concentrated Solutions of Noradrenaline Bitartrate in Polypropylene Syringes for Administration in the Intensive Care Unit
Author(s): Lardinois Benjamin, Pector Johan, Delcave Charlotte, Soumoy Laura, Jamart Jacques, Bihin B, Hecq Jean-Daniel, Galanti Laurence M
Jul/Aug 2019
Pg. 320-323
Long-term Physicochemical Stability of Concentrated Solutions of Sodium Valproate in Polypropylene Syringes for Administration in the Intensive Care Unit
Author(s): Lardinois Benjamin, Baltzis Alexandre, Braibant Maximilien, Soumoy Laura, Jamart Jacques, Bihin Benoît, Hecq Jean-Daniel, Galanti Laurence
Sep/Oct 2019
Pg. 434-437
Long-term Physiochemical Stability of Concentrated Solutions of Salbutamol (Albuterol) in Polypropylene Syringes for Use in the Intensive Care Unit and in Obstetrics
Author(s): Lardinois Benjamin, Baltzis Alexandre, Delcave Charlotte, Soumoy Laura, Jamart Jacques, Bihin Benoît, Hecq Jean-Daniel, Galanti Laurence
Mar/Apr 2019
Pg. 163-166
Evaluation of the Physicochemical Stability of Amiodarone Hydrochloride in Syringes for the Intensive Care Unit
Author(s): Lardinois Benjamin, Dimitriou Alexandre, Delcave Charlotte, Jamart Jacques, Bihin Benoît, Soumoy Laura, Hecq Jean-Daniel, Galanti Laurence M
Mar/Apr 2005
Pg. 152
Isosorbide Dinitrate 0.1% Topical Spray
Author(s): Allen Loyd V Jr
Jul/Aug 2016
Pg. 347-350
Long-term Stability of Vancomycin Hydrochloride in Oral Solution: The Brand Name Versus a Generic Product
Author(s): Huvelle Sophie, Godet Marie, Hecq Jean-Daniel, Gillet Patricia, Jamart Jacques, Galanti Laurence M
Mar/Apr 2025
Pg. 141-149
Long-term Physicochemical Stability of a Pharmaceutical Preparation of Morphine Hydrochloride and Droperidol in Polypropylene Syringes
Author(s): Nobels Amandine, Closset Mélanie, Bihin B, Jamart Jacques, Soumoy Laura, Lombet Louise, Hecq Jean-Daniel, Galanti Laurence, Colsoul Marie-Lise, Catry Emilie
Sep/Oct 2025
Pg. 439-446
Long-Term Physicochemical Stability of a Morphine-Ketamine Admixture in Polypropylene Syringes at Room Temperature
Author(s): Devis Luigi, Colsoul Marie-Lise, Bihin Benoît, Jamart Jacques, Soumoy Laura, Lombet Louise, Hecq Jean-Daniel, Galanti Laurence, Closset Mélanie, Catry Emilie
Jan/Feb 2014
Pg. 78-82
Long-term Stability of Morphine Hydrochloride in 0.9% NaCl Infusion Polyolefin Bags After Freeze-thaw Treatment and in Polypropylene Syringes at 5°C ± 3°C
Author(s): Hecq J-D, Godet M, Gillet P, Jamart J, Galanti L
Jul/Aug 2016
Pg. 328-332
Y-site Physical Compatibility of Beta-blocker Infusions with Intensive Care Unit Admixtures
Author(s): Foushee Jaime A, Meredith Pmichaele, Fox Laura M, Grace EdwardE
Nov/Dec 2017
Pg. 481-486
Basics of Compounding: Compounding Irrigation Solutions for Sterile and Nonsterile Preparations
Author(s): Allen Loyd V Jr
Jan/Feb 2004
Pg. 46-48
Basics of Compounding for Disorders of the External Ear
Author(s): Allen Loyd V Jr
Sep/Oct 2008
Pg. 456-459
Testing the Long-Term Stability of Vancomycin Ophthalmic Solution
Author(s): McLellan Christine, Ngo Van, Pasedis Sophia, Dohlman Claes H
Sep/Oct 2019
Pg. 414-417
Stability of Furosemide 5 mg/mL in Polypropylene Syringes
Author(s): van der Schaar JAJ, Grouls R, Franssen EJF, Crul M
May/Jun 2020
Pg. 242-245
Physicochemical Stability and Compatibility of Revefenacin (LAMA) and Formoterol Fumarate (LABA) Inhalation Solution Admixture
Author(s): Ngim Kenley, Patel Jalpa
Mar/Apr 2020
Pg. 156-162
Physicochemical Stability of Ternary Mixtures of Sufentanil, Baclofen, and Ropivacaine in Polypropylene Syringes for Intrathecal Analgesia
Author(s): Sorrieul Jérémy, Robert Julien, Chapel Fanny, Gossye Thomas, Devys Catherine
Mar/Apr 2004
Pg. 156-159
Effect of Freezing, Long-Term Storage and Microwave Thawing on the Stability of Tramadol in 5% Dextrose Infusion in Polyvinyl Chloride Bags
Author(s): Lebrun John, Hecq Jean-Daniel, Vanbeckbergen Danielle, Jamart Jacques, Galanti Laurence M
Jul/Aug 2022
Pg. 336-341
Long-term Stability of Epitheliotropic Factors in Frozen Serum Eye Drops
Author(s): Sahyoun Jean-Yves, Cloutier Marc, Frenette Mathieu, Robert Marie-Claude