Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Furosemide 5 mg/mL in Polypropylene Syringes

Author(s):  van der Schaar JAJ, Grouls R, Franssen EJF, Crul M

Issue:  Sep/Oct 2019 - Volume 23, Number 5
View All Articles in Issue

Abstract:  Furosemide parenteral solutions are routinely used in our hospital. However, the stability in transparent syringes is unknown. In this study, transparent polypropylene syringes were filled with 8 mL and 50 mL of furosemide 5-mg/mL solution. The furosemide was analyzed by high-performance liquid chromatography and assays were performed up to 35 days of storage of the syringes at 4°C protected from light, plus 24 hours at 20°C exposed to daylight. In addition, the appearance and pH of the solutions were determined. A microbiological assay using tryptic soy broth was also performed. Both types of syringes remained colorless, clear, and free from visible particles throughout the study period. The pH did not change, and concentrations remained between 95% and 105% of the stated concentration. None of the syringes filled with culture media exhibited bacterial or fungal growth. In conclusion, ready-to-administer furosemide 5-mg/mL, 8-mL, and 50-mL polypropylene syringes are stable for up to 35 days when stored in a refrigerator at 4°C protected from light, plus 24 hours at 20°C unprotected from light. These results allow maximum storage time in stock and the ability of 24-hour continuous infusion at ambient room temperature without protecting the syringe against light.

Related Keywords: J.A.J. van der Schaar, PharmD, R. Grouls, PharmD, PhD, E.J.F. Franssen, PharmD, PhD, M. Crul, PharmD, PhD, furosemide, short-acting loop diuretic, diuresis, acute pulmonary edema, edema, congestive heart failure, renal impairment, hepatic disease, liver dysfunction, ascites, hospital pharmacy, ready-to-administer batch production, parenteral administration, aseptic formulations, compounded sterile preparations, continuous infusion, photodegradation, transparent polypropylene syringes, chemical stability, physical stability, microbial stability, bacterial contamination


Printer-Friendly Version

Download in electronic PDF format for $55

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Furosemide 5 mg/mL in Polypropylene Syringes van der Schaar JAJ, Grouls R, Franssen EJF, Crul M Sep/Oct 2019 414-417 Buy
Treating Canine Hepatic Disease Davidson Gigi S May/Jun 2003 188-191 Buy
Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates) Brandin Thibaut, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice Mar/Apr 2022 150-154 Buy
Incorporating Quality Assurance in Pharmaceutical Compounding-related Courses in the PharmD Curricula Hossain Mohammad Faisal, Levesque Dan, Frye John, Rashid Mamoon Jul/Aug 2020 322-326 Buy
Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Breukels Oscar, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam Jul/Aug 2018 345-349 Buy
Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations Visser J Carolina, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J May/Jun 2018 247-251 Buy
Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal) Garrigue Philippe, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand Mar/Apr 2016 148-154 Buy
Furosemide 10-mg/mL Oral Suspension Allen Loyd V Jr Mar/Apr 2017 148 Buy
Furosemide 5-mg/mL Oral Suspension Allen Loyd V Jr Jul/Aug 2022 321-322 Buy
Stability Assessment of Repackaged Bevacizumab for Intravitreal Administration Pereboom Marieke, Becker Matthijs L, Amenchar Mostapha, Verweij Sjoerd L, van der Hoeven Ruud TM, Mulder Inge J Jan/Feb 2015 70-72 Buy