Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Furosemide 5 mg/mL in Polypropylene Syringes

Author(s):  van der Schaar JAJ, Grouls R, Franssen EJF, Crul M

Issue:  Sep/Oct 2019 - Volume 23, Number 5
View All Articles in Issue

Page(s):  414-417

Stability of Furosemide 5 mg/mL in Polypropylene Syringes Page 1
Stability of Furosemide 5 mg/mL in Polypropylene Syringes Page 2
Stability of Furosemide 5 mg/mL in Polypropylene Syringes Page 3
Stability of Furosemide 5 mg/mL in Polypropylene Syringes Page 4

Download in electronic PDF format for $65

Abstract:  Furosemide parenteral solutions are routinely used in our hospital. However, the stability in transparent syringes is unknown. In this study, transparent polypropylene syringes were filled with 8 mL and 50 mL of furosemide 5-mg/mL solution. The furosemide was analyzed by high-performance liquid chromatography and assays were performed up to 35 days of storage of the syringes at 4°C protected from light, plus 24 hours at 20°C exposed to daylight. In addition, the appearance and pH of the solutions were determined. A microbiological assay using tryptic soy broth was also performed. Both types of syringes remained colorless, clear, and free from visible particles throughout the study period. The pH did not change, and concentrations remained between 95% and 105% of the stated concentration. None of the syringes filled with culture media exhibited bacterial or fungal growth. In conclusion, ready-to-administer furosemide 5-mg/mL, 8-mL, and 50-mL polypropylene syringes are stable for up to 35 days when stored in a refrigerator at 4°C protected from light, plus 24 hours at 20°C unprotected from light. These results allow maximum storage time in stock and the ability of 24-hour continuous infusion at ambient room temperature without protecting the syringe against light.

Related Keywords: J.A.J. van der Schaar, PharmD, R. Grouls, PharmD, PhD, E.J.F. Franssen, PharmD, PhD, M. Crul, PharmD, PhD, furosemide, short-acting loop diuretic, diuresis, acute pulmonary edema, edema, congestive heart failure, renal impairment, hepatic disease, liver dysfunction, ascites, hospital pharmacy, ready-to-administer batch production, parenteral administration, aseptic formulations, compounded sterile preparations, continuous infusion, photodegradation, transparent polypropylene syringes, chemical stability, physical stability, microbial stability, bacterial contamination


Printer-Friendly Version

Related Articles from IJPC
(Click for Abstract / Details / Purchase)
Stability of Furosemide 5 mg/mL in Polypropylene Syringes
van der Schaar JAJ
, Grouls R, Franssen EJF, Crul M
Sep/Oct 2019
Pg. 414-417

Treating Canine Hepatic Disease
Davidson Gigi S
May/Jun 2003
Pg. 188-191

Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates)
Brandin Thibaut
, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice
Mar/Apr 2022
Pg. 150-154

Incorporating Quality Assurance in Pharmaceutical Compounding-related Courses in the PharmD Curricula
Hossain Mohammad Faisal
, Levesque Dan, Frye John, Rashid Mamoon
Jul/Aug 2020
Pg. 322-326

Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations
Visser J Carolina
, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J
May/Jun 2018
Pg. 247-251

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags
Breukels Oscar
, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam
Jul/Aug 2018
Pg. 345-349

Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal)
Garrigue Philippe
, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand
Mar/Apr 2016
Pg. 148-154

Furosemide 10-mg/mL Oral Suspension
Allen Loyd V Jr
Mar/Apr 2017
Pg. 148

Furosemide 5-mg/mL Oral Suspension
Allen Loyd V Jr
Jul/Aug 2022
Pg. 321-322

Stability Assessment of Repackaged Bevacizumab for Intravitreal Administration
Pereboom Marieke
, Becker Matthijs L, Amenchar Mostapha, Verweij Sjoerd L, van der Hoeven Ruud TM, Mulder Inge J
Jan/Feb 2015
Pg. 70-72