Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Compounded Melatonin Cream for the Prevention and Treatment of Radiation Dermatitis: A Case Report

Author(s):  Garcia-Segura Laura Corral, Garcia-Segura Javier Corral, Delgado Carlos Dorado, Maldonaldo Nuria Romero, Salgado Elena Cardero, Llorens Lucía Pérez

Issue:  Jan/Feb 2022 - Volume 26, Number 1
View All Articles in Issue

Page(s):  6-8

Compounded Melatonin Cream for the Prevention and Treatment of Radiation Dermatitis: A Case Report Page 1
Compounded Melatonin Cream for the Prevention and Treatment of Radiation Dermatitis: A Case Report Page 2
Compounded Melatonin Cream for the Prevention and Treatment of Radiation Dermatitis: A Case Report Page 3

Download in electronic PDF format for $65

Abstract:  Radiation-induced dermatitis is a common complication of radiotherapy. In Spain, the manufactured products used to prevent and treat that condition consist of emollient creams (which are often ineffective) or corticosteroids (which can cause dermal atrophy and other adverse effects). However, we have found that topically applied melatonin, a product that to our knowledge is not commercially available in Spain, is safe and effective in the prevention and treatment of radiodermatitis and a viable substitute for corticosteroid therapy. In this report, we describe the use of compounded melatonin in Beeler cream (the formulation for which is provided) in a 46-year-old woman who underwent surgery and radiotherapy for early stage adenocarcinoma of the breast. The patient applied that cream as directed throughout the prescribed course of radiotherapy and continued its use for 3 weeks after she last underwent irradiation. She experienced no adverse effects from the use of the compounded formulation and tolerated that treatment well. Radiation dermatitis did not develop at the irradiated site until approximately 1 week after the final radiotherapy session, at which time mild erythema of the treated skin emerged. That condition, which was successfully treated by application of the melatonin-containing cream as previously prescribed, resolved after 3 weeks of its use. We suggest that when manufactured products designed to prevent or treat the adverse dermal effects of radiotherapy are unavailable, fail to be effective, or prove objectionable to patients, a melatonin-containing topical compound can provide a successful alternative.

Related Keywords: Laura Corral García-Segura, PharmD, MSc, Javier Corral García-Segura, PharmD, Carlos Delgado Dorado, BSc, Nuria Romero Maldonado, MD, Elena Cardero Salgado, PharmD, MSc, Lucía Pérez Llorens, PharmD, melatonin, topical preparations, formulation, radiotherapy, radiation-induced dermatitis, skin irritation, Beeler cream, short-term adverse effects, long-term adverse effects, desquamation, erythema, pruritus, edema, tenderness, case report

Related Categories: CANCER AND AIDS, DERMATOLOGY, FORMULATIONS, CASE REPORTS, DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Compounded Melatonin Cream for the Prevention and Treatment of Radiation Dermatitis: A Case Report
Garcia-Segura Laura Corral
, Garcia-Segura Javier Corral, Delgado Carlos Dorado, Maldonaldo Nuria Romero, Salgado Elena Cardero, Llorens Lucía Pérez
Jan/Feb 2022
Pg. 6-8

Sensitization Therapy for Warts
Kuntz Rachael
Jul/Aug 2003
Pg. 266-270

Pediatric Dermatitis
Remmert Renee
Nov/Dec 2002
Pg. 419-421

Basics of Compounding for Raynaud's Disease
Glasnapp Andrew
Jul/Aug 2003
Pg. 288-291

Goliath: Case Report on a Canine Case of Epilepsy
Ameijeiras Carlos
, Ray Jody, Jordan Dinah G, Garcia Abby Furr
Jan/Feb 2011
Pg. 27-31

Incorporating Quality Assurance in Pharmaceutical Compounding-related Courses in the PharmD Curricula
Hossain Mohammad Faisal
, Levesque Dan, Frye John, Rashid Mamoon
Jul/Aug 2020
Pg. 322-326

Potential Treatments for Radiation Dermatitis
Corsini Lindsay
May/Jun 2010
Pg. 210-213

Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats
Nani Marcel
, Leone Andréia, Bom Vinícius Pedro, Buszinski Andrei Felipe, Oliveira de Souza Rebeca, Pinheiro Vanessa Alves, Danapoulos Panagiota, Swikidisa Rosita, Marquele-Oliveira Franciane, Cipriani Frade Marco Andrey, Berretta Andresa Aparecida, Nogueira Rodrigo José Lupatini
Mar/Apr 2018
Pg. 154-163

Treatment of Dermatologic Adverse Events Induced by Oncological Treatments Using Compounded Medications
Zur Eyal
Nov/Dec 2018
Pg. 446-454

Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates)
Brandin Thibaut
, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice
Mar/Apr 2022
Pg. 150-154

Compounding in the Pharmacy Curriculum: Beyond the Basics
Hinkle Amanda R
, Newton Gail D
May/Jun 2004
Pg. 181-185

Physical and Chemical Stability of Urapidil in 0.9% Sodium Chloride in Elastomeric Infusion Pump
Tomasello Cristina
, Leggieri Anna, Rabbia Franco, Veglio Franco, Baietto Lorena, Fulcheri Chiara, De Nicolò Amedeo, De Perri Giovanni, D'Avolio Antonio
Jul/Aug 2016
Pg. 343-346

Stability Assessment of Repackaged Bevacizumab for Intravitreal Administration
Pereboom Marieke
, Becker Matthijs L, Amenchar Mostapha, Verweij Sjoerd L, van der Hoeven Ruud TM, Mulder Inge J
Jan/Feb 2015
Pg. 70-72

Long-term Stability of Esomeprazole in 5% Dextrose Infusion Polyolefin Bags at 5°C ± 3°C after Microwave Freeze-thaw Treatment
Hecq Jean-Daniel
, Rolin Catherine, Godet Marie, Gillet Patricia, Jamart Jacques, Galanti Laurence M
Nov/Dec 2015
Pg. 521-524

Case Report: Diabetic Foot Ulcer Infection Treated with Topical Compounded Medications
Agbi Kelechi E
, Carvalho Maria, Phan Ha, Tuma Cristiane
Jan/Feb 2017
Pg. 22-27

Management of Psoriasis with a XemaTop Topical Compounded Formula: A Case Report
Jones Nat
, Carvalho Maria, Branvold-Herr Andrea
May/Jun 2017
Pg. 205-211

Case Report: Hydroxyprogesterone Caproate Injection for Prevention of Preterm Labor
Fields Shannon W
May/Jun 2006
Pg. 172

Case Report: The Use of Topical Concentrated Capsaicin Cream to Treat Erythromelalgia in a Pediatric Patient
McElhiney Linda F
May/Jun 2011
Pg. 194-199

Unlicensed Transdermal Medications in Feline Patients: Three Case Reports
Urwin Craig
, Jean Linda, Carvalho Maria, Robson-Laws Michael
Nov/Dec 2022
Pg. 468-472

Case Reports on the Use of Aloe Vera, Naltrexone, and Topiramate for the Treatment of Scars
Harris Kylie
, Wright Edward
Nov/Dec 2021
Pg. 482-485