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The Role of Sex Hormones on Fibromyalgia Pain Mediators

Author(s):  Bramwell Bethany L

Issue:  May/Jun 2010 - Pain Management
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Abstract:  Understanding the role of the sex hormones in the pain mechanisms and various effects on nociceptors is imperative to managing potential underlying hormone disruptions in chronic pain syndromes. The myriad of overlapping symptoms between mid-life hormone imbalances and mid-life onset of fibromyalgia syndrome in women indicates a role for sex hormones in the etiology of fibromyalgia syndrome, which is, as of yet, unsupported by the literature. However, fibromyalgia treatment should be tailored to the individual needs of the patient, and adrenal, thyroid, and ovarian hormone support can lessen the painful burden of fibromyalgia through the modulation of various hormone-regulated pain-production pathways.

Related Keywords: Bethany L. Bramwell, BSPharm, RPh, sex hormone receptors, fibromyalgia syndrome, nociceptors, chronic pain, musculoskeletal disorders, menopause, hormone deficiency, formulations, dehydroepiandrosterone, DHEA, progesterone, topical preparations, androgen, substance P, neurotransmitters, hyperalgesia, pain receptors, sex steroids, estrogen, thyroid disorders, thyroid hormones, hormone replacement therapy


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