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Extemporaneous Preparation of Sertraline Cream for Transdermal Administration

Author(s):  Wynn Tom, Goetsch Daniel

Issue:  May/Jun 2011 - Volume 15, Number 3
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Abstract:  The antidepressant effects of selective serotonin reuptake inhibitors are currently attributed to responses exhibited after periods of prolonged administration. Postulations have been formed accrediting the successful treatment of anxiety-related disorders with selective serotonin reuptake inhibitors to a similar mechanism of action as displayed in the treatment of depression. One of the drugs in this class is sertraline. This article provides a case report of a pediatric patient diagnosed with an anxiety disorder who was treated with transdermal sertraline. The compounding of dosage forms tailored to meet patient-specific needs may be an integral part in the successful delivery of selective serotonin reuptake inhibitor therapy.

Related Keywords: Tom Wynn, RPh, Daniel Goetsch, transdermal administration, sertraline, anxiety disorders, children, case report, formulation, selective serotonin reuptake inhibitor, SSRI

Related Categories: FORMULATIONS, MENTAL HEALTH, PEDIATRICS, CASE REPORTS, DOSAGE FORMS/DRUG CARRIERS

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