Evaluation of Compounded Transdermal Analgesic Formulations Using the Franz Finite Dose Model

Baneshi, Marzieh; Tyagi, Deependra; Panneerselvam, Ezilrani; MacKenzie, Graham; Coleman, Johngary; Zhang, Shine X

Abstract

Evaluation of Compounded Transdermal Analgesic Formulations Using the Franz Finite Dose Model

Author(s): Baneshi Marzieh, Tyagi Deependra, Panneerselvam Ezilrani, MacKenzie Graham, Coleman Johngary, Zhang Shine X

Issue: Sep/Oct 2023 - Volume 27, Number 5

View All Articles in Issue

Page(s): 424-430

Download in electronic PDF format for $75

Abstract

To evaluate the transdermal delivery of six analgesic drugs (i.e., ketamine, gabapentin, clonidine, lidocaine, ketoprofen, and amitriptyline) that were compounded into three commercially available bases, Salt Stable LS Base, Transdermal Pain Base, and Lipoderm ActiveMax Base, the Franz finite dose model was used for an in vitro penetration study using porcine skin over 48 hours. Rapid penetration with a steady-state flux after the first 24 hours was detected in all the formulations. The present study demonstrates the successful delivery of six compounded analgesic drugs, using all of the noted bases. A high flux rate within 1 hour to 4 hours of application would correlate to effective pain relief, and the prolonged delivery over the first 24 hours would reduce the need for frequent reapplication. This can aid in pain management with the potential for enhanced pain control.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Mar/Apr 2003 Pg. 106-113	Veterinary Transdermal Medications: A to Z Author(s): Davidson Gigi S
Sep/Oct 2023 Pg. 424-430	Evaluation of Compounded Transdermal Analgesic Formulations Using the Franz Finite Dose Model Author(s): Baneshi Marzieh, Tyagi Deependra, Panneerselvam Ezilrani, MacKenzie Graham, Coleman Johngary, Zhang Shine X
Mar/Apr 2015 Pg. 167-173	Analgesic Efficacy and Transdermal Penetration of Topical Gabapentin Creams: Finding an Optimal Dose and Pre-treatment Time Author(s): Heustess Allie, Spigener Shuler, Sweitzer Sarah, Romero-Sandoval Alfonso, Asbill Scott
Mar/Apr 2015 Pg. 161-166	Skin Permeation and Antinociception of Compounded Topical Cyclobenzaprine Hydrochloride Formulations Author(s): Bryson Evan, Hartman Rachel, Arnold John, Gorman Greg, Sweitzer Sarah.Asbill Scott
Jul/Aug 2004 Pg. 269-274	Current Topical Treatments in Wound Healing - Part 1 Author(s): Helmke Christopher D
Nov/Dec 2014 Pg. 512-515	In Vitro Skin Penetration and Skin Content of Progesterone from Various Topical Formulations Author(s): Heustess Allie, Asbill Scott, Eagerton David, Arnold John
May/Jun 2014 Pg. 256-261	Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery Author(s): Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth
Nov/Dec 2014 Pg. 504-511	Skin Penetration and Antinociception of Topical Gabapentin Formulations Author(s): Bryson Evan, Asbill Scott, Sweitzer Sarah
May/Jun 2016 Pg. 250-256	Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Author(s): Trimble John, Light Bob
May/Jun 2010 Pg. 182-192	Compounded Analgesic Therapy for Disorders of Movement: Arthritis, Neuropathic Pain, and Postpolio Syndrome Author(s): Brown Scott, Erickson Brian, Muller George, Bryant-Snure Susan J, Mestayer Richard F III
Mar/Apr 2021 Pg. 146-155	In Vitro Permeability, Irritability, and Release Evaluation of Commonly Used Topical Diclofenac Gel Preparations (1%, 5%, and 10%) Author(s): Kohan Hamed Gilzad, Baker David M, Sani Shabnam, Bielecki-Wilken Kathleen A, Ramirez Alfonso
Nov/Dec 2020 Pg. 446-448	NASEM Report on Compounded Topical Pain Creams Author(s): Allen Loyd V Jr
Mar/Apr 2015 Pg. 152-160	Transdermal Delivery of Nisoldipine: Refinement of Vehicles Author(s): El Maghraby Gamal M, Ahmed Amal A, Osman Mohamed A
Jul/Aug 2015 Pg. 295-300	Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review Author(s): Beshay Sarah M, Rivera Gerard, Balthasar Jan, Florea Naomi
Mar/Apr 2024 Pg. 111-116	Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review Author(s): Beshay Sarah M, Rivera Gerard, Balthasar Jan, Florea Naomi
Nov/Dec 2017 Pg. 530-535	Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Author(s): Trimble John O, Light Bob
Nov/Dec 2018 Pg. 498-503	Gabapentin in Elastic Liposomes: Preparation, Characterization, Drug Release, and Penetration Through Porcine Skin Author(s): Le Uyen Minh, Baltzley Sarah, AlGhananeem Abeer
Jul/Aug 2011 Pg. 308-315	Transdermals: The Skin as Part of a Drug Delivery System Author(s): Allen Loyd V Jr
May/Jun 2010 Pg. 200-203	Topical Medications for Orofacial Neuropathic Pain Author(s): Bramwell Bethany L
Jul/Aug 2001 Pg. 310-312	Wetting and/or Solubilizing Agents, Featured Excipient: Author(s): Allen Loyd V Jr