International Journal of Pharmaceutical Compounding

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Bilateral Areolar Hyperpigmentation Following Transdermal Administration of Compounded Hormone Replacement Therapy

Author(s): Griffee Chris, Delano Amy

Issue: Mar/Apr 2012 - Volume 16, Number 2
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Page(s): 110-114

Bilateral Areolar Hyperpigmentation Following Transdermal Administration of Compounded Hormone Replacement Therapy Page 1

Bilateral Areolar Hyperpigmentation Following Transdermal Administration of Compounded Hormone Replacement Therapy Page 2

Bilateral Areolar Hyperpigmentation Following Transdermal Administration of Compounded Hormone Replacement Therapy Page 3

Bilateral Areolar Hyperpigmentation Following Transdermal Administration of Compounded Hormone Replacement Therapy Page 4

Bilateral Areolar Hyperpigmentation Following Transdermal Administration of Compounded Hormone Replacement Therapy Page 5

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Abstract: A 61-year-old postmenopausal Caucasian woman presented to the pharmacy to re-initiate hormone therapy after having discontinued treatment for three years. She had discontinued previous hormone therapy due to severe hyperpigmentation of both nipples and areola. She stated that her nipples and areola had turned black, as if they had been burned. This reaction seemed unique, and we felt that it warranted further investigation.

Related Keywords: Chris Griffee, Amy Delano, PharmD, case report, hormone replacement therapy, adverse affects, hyperpigmentation, skin darkening, nipples, areola, topical preparation, transdermal administration, estradiol, estriol, progesterone, lozenge, formulations

Related Categories: DERMATOLOGY, FORMULATIONS, HRT, CASE REPORTS, DOSAGE FORMS/DRUG CARRIERS

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