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Disguising the Taste of Antiretrovirals for Pediatric Patients Infected with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Creative Flavor Compounding and Techniques, Part 2

Author(s):  Horace Alexis E, Akbarian-Tefagh Jessica

Issue:  Nov/Dec 2013 - Volume 17, Number 6
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Abstract:  Adherence to antiretrovirals for pediatric patients is challenging for a variety of reasons, many of which are quite obvious. The medication’s taste and texture may contribute to a child’s resistance to following their regimen. To make the problem of compliance even more complex, there are fewer pediatric-friendly formulations available and fewer alternative options for antiretrovirals when compared to formulations and alternatives available to adults. For the sake of compliance, it is vital that parents and/or caregivers be offered innovative ways to disguise the taste of antiretrovirals for pediatric patients infected with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. Compounding pharmacists can play an important role in finding answers to this situation. This article provides an in-depth discussion on some of the specific flavoring and taste-masking options that are available in the effort to increase adherence in the pediatric patient population.

Related Keywords: Alexis E. Horace, PharmD, Jessica Akbarian-Tefagh, antiretroviral agents, children, infants, human immunodeficiency virus, HIV, acquired immunodeficiency syndrome, AIDS, patient adherence, disguising taste, flavoring, aftertaste, didanosine, stavudine, tenofovir, zidovudine, abacavir, emtricitabine, lamivudine, efavirenz, nevirapine, fosamprenavir, lopinavir, ritonavir, nelfinavir, tipranavir, FLAVORx, palatability, medium chain triglycerides, MCTs

Related Categories: CANCER AND AIDS, EXCIPIENTS, PEDIATRICS, PATIENT COMPLIANCE, INFECTIOUS DISEASE

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