Abstract

Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes

Author(s): Anderson Collin R, Halford Zachery, MacKay Mark

Issue: Jul/Aug 2015 - Volume 19, Number 4

Page(s): 344-347

Download in electronic PDF format for $75
  • Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes Page 1
  • Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes Page 2
  • Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes Page 3
  • Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes Page 4

Abstract

Chemotherapy-induced nausea and vomiting is problematic for many patients undergoing chemotherapy. Multiple-drug treatments have been developed to mitigate chemotherapy induced nausea and vomiting. A patient-controlled infusion of diphenhydramine hydrochloride, lorazepam, and dexamethasone sodium phosphate has been studied in patients who are refractory to first-line therapy. Unfortunately, the physical and chemical compatibility of this three-drug combination is not available in the published literature. Chemical compatibility was evaluated using high-performance liquid chromatography with ultraviolet detection. Visual observation was employed to detect change in color, clarity, or gas evolution. Turbidity and pH measurements were performed in conjunction with visual observation at hours 0, 24, and 48. Results showed that diphenhydramine hydrochloride 4 mg/mL, lorazepam 0.16 mg/mL, and dexamethasone sodium phosphate 0.27 mg/mL in 0.9% sodium chloride stored in polypropylene syringes were compatible, and components retained greater than 95% of their original concentration over 48 hours when stored at room temperature.

Related Keywords

  • diphenhydramine hydrochloride
  • lorazepam
  • dexamethasone sodium phosphate
  • chemotherapy-induced nausea and vomiting
  • CINV
  • cancer
  • drug combination
  • physical compatibility
  • chemical compatibility
  • emesis
  • antiemesis
  • antiemetic therapy
  • BAD pump
  • patient-controlled infusion
  • compounded sterile preparations
  • stability
  • isotonic normal saline solution

Related Categories

  • CANCER AND AIDS
  • EXCIPIENTS
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • ADVERSE DRUG EVENTS
  • STORAGE

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Jul/Aug 2015
Pg. 344-347
Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes
Author(s): Anderson Collin R, Halford Zachery, MacKay Mark
Nov/Dec 2015
Pg. 508
Dexamethasone Sodium Phosphate Ophthalmic Solution: Equivalent to 0.1% Dexamethasone Phosphate
Author(s): Allen Loyd V Jr
Mar/Apr 2020
Pg. 168-175
Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel
Author(s): Dahal Amit, Neupane Rabin, Boddu Sai HS, Renukuntla Jwala, Khupse Rahul, Dudley Richard
Sep/Oct 2004
Pg. 398-403
Compatibility and Stability of Aloxi (Palonosetron Hydrochloride) Admixed With Dexamethasone Sodium Phosphate
Author(s): Trissel Lawrence A, Zhang Yanping
Jan/Feb 2017
Pg. 66-75
Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Dexamethasone Sodium Phosphate
Author(s): Wu George, Yeung Stanley, Chen Frank
Sep/Oct 2002
Pg. 395-397
Chemical Stability of Dexamethasone Sodium Phosphate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes
Author(s): Gupta Vishnu D
Mar/Apr 2017
Pg. 150-153
Stability of Alprostadil in 0.9% Sodium Chloride Stored in Polyvinyl Chloride Containers
Author(s): McCluskey Susan V, Kirkham Kylian, Munson Jessica M
May/Jun 2018
Pg. 237
Rolapitant Injectable Emulsion with Dexamethasone Sodium Phosphate Admixture
Author(s): Allen Loyd V Jr
Jan/Feb 2018
Pg. 76-85
Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride Injection and Dexamethasone Sodium Phosphate Injection
Author(s): Wu George, Powers Dan, Yeung Stanley, Chen Frank
Sep/Oct 2017
Pg. 426-429
Stability of Dalteparin 1,000 Unit/mL in 0.9% Sodium Chloride for Injection in Polypropylene Syringes
Author(s): Kirkham Kylian, Munson Jessica M, McCluskey Susan V, Graner Kevin K
Jul/Aug 2003
Pg. 310-312
Chemical Stability of Cefuroxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Author(s): Gupta Vishnu D
Jul/Aug 2000
Pg. 297
Dexamethasone 1.2%, Lorazepam 0.1%, Haloperidol 0.1%, Diphenhydramine HCl 2.4% and Metoclopramide HCl 2.4% in PLO
Author(s): Allen Loyd V Jr
Mar/Apr 2003
Pg. 155-159
Quantification of Total Dexamethasone Phosphate Delivery by Iontophoresis
Author(s): Anderson Carter R, Boeh Stephen D, Morris Russell L, Sembrowich Walter L, Panus Peter C
Mar/Apr 2003
Pg. 152-154
Chemical Stability of Cefazolin Sodium after Reconstituting in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Author(s): Gupta Vishnu D
Jan/Feb 2019
Pg. 54
Lidocaine Hydrochloride, Diphenhydramine Hydrochloride, Aluminum Hydroxide–Magnesium Hydrochloride–Simethicone Mouthwashes
Author(s): Allen Loyd V Jr
Jul/Aug 2021
Pg. 330-335
Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions
Author(s): Wolfe Amanda, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan
Nov/Dec 2018
Pg. 516-526
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Author(s): Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
Mar/Apr 1998
Pg. 147
Dexamethasone Sodium Phosphate 1-mg/mL for Iontophoresis
Author(s): Allen Loyd V Jr
May/Jun 1998
Pg. 227
Dexamethasone Sodium Phosphate 0.05% Ophthalmic Ointment
Author(s): Allen Loyd V Jr
Nov/Dec 1997
Pg. 435-436
Stability of Cefepime Hydrochloride Dextrose in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Author(s): Gupta Vishnu D, Maswoswe J, Bailey RE