Chemical Stability of Cefuroxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Author(s): Gupta Vishnu D
Issue: Jul/Aug 2003 - After the Women's Health Initiative Trial
View All Articles in Issue
Page(s): 310-312
Download in electronic PDF format for $75
Abstract: The stability of cefuroxime sodium (50 mg/mL) in 0.9%
sodium chloride injection stored in polypropylene syringes
was studied at 25 and 5ºC by means of a stability-indicating
high-performance liquid chromatographic assay method.
The concentrations of the drug were directly related to
peak heights, and the percent relative standard deviation
based on five injections was 0.9. There were at least two
products of decomposition that separated from the intact
drug. The loss in potency was less than 10% after 2 days of
storage at 25ºC, and the loss in potency was less than 4%
after 21 days of storage at 5ºC. The pH value increased
from 6.9 to 7.3 when the injection was stored at 25ºC for
2 days, and the pH value increased from 6.9 to 7.0 when
the injection was stored at 5ºC for 21 days. The drug was
not adsorbed onto the syringes. The intensity of the lightyellow
color increased with the storage period at 25ºC but
did not change significantly with storage at 5ºC.
Related Keywords:
Cefuroxime sodium, stability of, for pediatric use, Stability of cefuroxime sodium for pediatric use
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Chemical Stability of Cefuroxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
|
Jul/Aug 2003
Pg. 310-312
|
Chemical Stability of Cefazolin Sodium after Reconstituting in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
|
Mar/Apr 2003
Pg. 152-154
|
Stability of Piperacillin Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
May/Jun 2001
Pg. 230-231
|
Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Jan/Feb 2001
Pg. 75-77
|
Stability of Ethacrynate Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Jan/Feb 2001
Pg. 73-75
|
Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs.
Xu Quanyun A, Trissel Lawrence A, Pham Lien
|
May/Jun 2004
Pg. 228-230
|
Stability of Cefotaxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
|
May/Jun 2002
Pg. 234-236
|
Stability of Nafcillin Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Nov/Dec 2000
Pg. 480-481
|
Stability of Hydrocortisone Sodium Succinate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Sep/Oct 2000
Pg. 396-397
|
Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion
Gupta Vishnu D
|
Mar/Apr 2004
Pg. 153-155
|
Stability of Dalteparin 1,000 Unit/mL in 0.9% Sodium Chloride for Injection in Polypropylene Syringes
Kirkham Kylian, Munson Jessica M, McCluskey Susan V, Graner Kevin K
|
Sep/Oct 2017
Pg. 426-429
|
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Zhang Yan-ping, Trissel Lawrence A
|
Mar/Apr 1997
Pg. 132-134
|
Stability of Cefmetazole Sodium in 5% dextrose Injection and 0.9% Sodium Chloride Injection
Gupta Vishnu D, Maswoswe J, Bailey RE
|
May/Jun 1997
Pg. 208-209
|
Chemical Stability of Methylprednisolone Sodium Succinate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes
Gupta Vishnu D
|
Mar/Apr 2001
Pg. 148-150
|
Stability of Cefepime Hydrochloride After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Mar/Apr 2001
Pg. 151-152
|
Chemical Stability of Dexamethasone Sodium Phosphate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes
Gupta Vishnu D
|
Sep/Oct 2002
Pg. 395-397
|
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags
Zhang Yanping, Trissel Lawrence A
|
May/Jun 2002
Pg. 226-229
|
Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions
Wolfe Amanda, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan
|
Jul/Aug 2021
Pg. 330-335
|
Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection
Gupta Vishnu D, Bailey RE
|
Jan/Feb 2000
Pg. 66-68
|
Pediatric Compounding: Coloring Outside the Lines
Preckshot John
|
Jan/Feb 2001
Pg. 6-8
|
| Return to Top |
