Abstract

Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes

Author(s): McHenry Adam R, Wempe Michael F, Rice Peter J

Issue: May/Jun 2017 - Volume 21, Number 3

Page(s): 251-254

Download in electronic PDF format for $75
  • Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes Page 1
  • Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes Page 2
  • Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes Page 3
  • Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes Page 4

Abstract

This study evaluated the stability of the antimalarial and anti-rheumatic drug hydroxychloroquine sulfate in two commercially available suspension vehicles, Oral Mix and Oral Mix SF (Medisca Pharmaceutique Inc.). Hydroxychloroquine sulfate (25 mg/mL) suspension was prepared, packaged in amber 50-mL polyethylene terephthalate bottles and amber 3-mL syringes, and stored at room temperature or at 4°C. Samples were collected and analyzed over a 16-week period by high-performance liquid chromatography with ultraviolet detection at 340 nm. Approximately 99.8% of the hydroxychloroquine remained at the conclusion of the study, with no observable difference between room temperature and refrigerated storage. Hydroxychloroquine sulfate is stable for at least 90 days in Medisca Oral Mix or Oral Mix SF suspension media at 25°C and 4°C.

Related Keywords

  • hydroxychloroquine sulfate
  • antimalarial agent
  • rheumatic disorders
  • malaria
  • stability
  • suspension vehicle comparison
  • storage materials
  • storage containers

Related Categories

  • PACKAGING
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
May/Jun 2017
Pg. 251-254
Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes
Author(s): McHenry Adam R, Wempe Michael F, Rice Peter J
Jul/Aug 2020
Pg. 316
Hydroxychloroquine Sulfate 25 mg/mL in Ora-Plus:Ora-Sweet SF
Author(s): Allen Loyd V Jr
Nov/Dec 2017
Pg. 494
Hydroxychloroquine Sulfate 25 mg/mL in Oral Mix or Oral Mix SF
Author(s): Allen Loyd V Jr
Jan/Feb 2015
Pg. 66
Hydroxychloroquine Sulfate 200-mg Capsules
Author(s): Allen Loyd V Jr
May/Jun 2004
Pg. 181-185
Compounding in the Pharmacy Curriculum: Beyond the Basics
Author(s): Hinkle Amanda R, Newton Gail D
Mar/Apr 2021
Pg. 163-168
Stability of Extemporaneously Compounded Nadolol 10-mg/mL Suspension in Oral Mix in Glass and Plastic Bottles and Plastic Syringes
Author(s): Walsh Andrea, Ziegler Blake, Lingertat-Walsh Karen, Law Shirley, Walker Scott E
Mar/Apr 2017
Pg. 160-163
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Author(s): Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
Jan/Feb 2002
Pg. 66-69
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes
Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Jan/Feb 2002
Pg. 70-73
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes
Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
May/Jun 2003
Pg. 233-239
Formulation Development and Stability Testing of Extemporaneous Suspension Prepared From Dapsone Tablets
Author(s): Kaila Nitin, El-Ries Mohamed, Riga A, Alexander Kenneth S, Dollimore D
Jan/Feb 2004
Pg. 46-48
Basics of Compounding for Disorders of the External Ear
Author(s): Allen Loyd V Jr
Mar/Apr 2002
Pg. 152-154
Stability of Gentamicin Sulfate and Tobramycin Sulfate in AutoDose Infusion System Bags
Author(s): Xu Quanyun A, Trissel Lawrence A, Saenz Christopher A, Ingram Delshalonda S
Jan/Feb 2002
Pg. 62-65
Physical and Chemical Stability of Morphine Sulfate 5-mg/mL and 50-mg/mL Packaged in Plastic Syringes
Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
Jul/Aug 2018
Pg. 326-328
Stability of Extemporaneously Prepared Sodium Benzoate Oral Suspension
Author(s): Atkins Julia R, Lull Melinda E, Decker Andrew S, Hutchinson David J
Jul/Aug 2019
Pg. 318
Morphine Sulfate 0.2-mg/mL Solution Stored in Amber Oral Plastic Syringes
Author(s): Allen Loyd V Jr
Sep/Oct 2021
Pg. 412
Atropine Sulfate 0.1 mg/mL in SyrSpend SF pH4 Oral Suspension
Author(s): Allen Loyd V Jr
Jul/Aug 2001
Pg. 310-312
Wetting and/or Solubilizing Agents, Featured Excipient:
Author(s): Allen Loyd V Jr
Jul/Aug 2018
Pg. 340-344
Comparative Stability of Vitamin K1 Oral Liquids Prepared in Sterile Water for Injection and Stored in Amber Glass Bottles and Amber Plastic Syringes
Author(s): Huffman Jessica, Brown Stacy, Lewis Paul, Lawson Sarah, Ogle Amanda, Peacock Gina
Sep/Oct 2021
Pg. 431-439
Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt
Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Sep/Oct 2006
Pg. 396-399
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions
Author(s): Trissel Lawrence A, Zhang Yanping, Koontz Susannah E