Stability of Extemporaneously Prepared Sodium Benzoate Oral Suspension
Author(s): Atkins Julia R, Lull Melinda E, Decker Andrew S, Hutchinson David J
Issue: Jul/Aug 2018 - Volume 22, Number 4
View All Articles in Issue
Page(s): 326-328
Download in electronic PDF format for $65
Abstract: The stability of extemporaneously prepared sodium benzoate oral suspension in cherry syrup and Ora-Sweet was studied. Oral solutions of 250-mg/mL sodium benzoate were prepared in either cherry syrup or Ora-Sweet. To a beaker, 50 grams of Sodium Benzoate Powder USP was dissolved and filtered, the solution was divided equally into two parts, and each aliquot was added into two separate calibrated 100-mL amber vials. In the first vial, cherry syrup was added to make a final volume of 100 mL. In the second vial, Ora-Sweet was added to give a final volume of 100 mL. This process was repeated to prepare three solutions of each kind and all were stored at room temperature. A 250-µL sample was withdrawn immediately after preparation and again at 7, 14, 28, 60, and 90 days for each sample. At each time point, further dilution was made to an expected concentration of 0.25 mg/mL with sample diluent, and the samples were assayed in triplicate by stability-indicating high-performance liquid chromatography. Stability was defined as the retention of at least 90% of the initial concentration. At least 92% of the initial concentration of sodium benzoate in cherry syrup and at least 96% of the sodium benzoate in Ora-Sweet remained throughout the 90-day study period. There were no detectable changes in color and no visible microbial growth in any sample. Extemporaneously compounded suspensions of sodium benzoate in cherry syrup or Ora-Sweet were stable for at least 90 days when stored in a 4-oz amber plastic bottle at room temperature in reduced lighting.
Related Keywords:
Julia R. Atkins, BS, PharmD Candidate, Melinda E. Lull, PhD, Andrew S. Decker, PharmD, David Hutchinson, PharmD, BCPS, BCPPS, sodium benzoate, urea cycle disorders, nitrogenous waste, nitrogen ammonia scavenger, formulation, stability
Related Categories:
FORMULATIONS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, STORAGE, UROLOGY/URINARY TRACT
Printer-Friendly Version
Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Stability of Extemporaneously Prepared Sodium Benzoate Oral Suspension
Atkins Julia R, Lull Melinda E, Decker Andrew S, Hutchinson David J
|
Jul/Aug 2018
Pg. 326-328
|
Finding the Right Balance: A Nationwide Study of Student Pharmacist Exposure to and Perceptions of Nonsterile Compounding
Fredrickson Mary E, Belcher Faith G, Del Vecchio Kamryn N, Galleher Miranda N, Jugo Leila S, Gothard M David, Pallotta Raneem H, Pallotta Victor A Jr
|
May/Jun 2022
Pg. 242-247
|
Development and Validation of a Stability-indicating High-performance Liquid Chromatographic Method for Quantification of Progesterone in Compounded Glycerinated Gelatin Troches
Burrows Anna C, Yellepeddi Venkata Kashyap, Snyder Spencer, Wakefield Meagan, Jackson David, Huynh Johnny, Nguyen Khoa, Sayre Casey L
|
Jul/Aug 2019
Pg. 340-350
|
Incorporating Quality Assurance in Pharmaceutical Compounding-related Courses in the PharmD Curricula
Hossain Mohammad Faisal, Levesque Dan, Frye John, Rashid Mamoon
|
Jul/Aug 2020
Pg. 322-326
|
Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates)
Brandin Thibaut, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice
|
Mar/Apr 2022
Pg. 150-154
|
Compounding for Diabetic Patients:An Interview with Paul Lofholm, PharmD
Allen Loyd V Jr
|
Nov/Dec 1997
Pg. 381-385
|
Compounding and Comparative Study of a Superior, Faster, and More Adaptable Lidocaine Dental Gel Formulation
Rashid Mamoon, Hossain Mohammad Faisal, Nounou Mohamed, Rahman Mehbuba, Sarkar Sushanta, Adeyemo Akinola, Mullins Randy
|
May/Jun 2019
Pg. 250-257
|
Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal)
Garrigue Philippe, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand
|
Mar/Apr 2016
Pg. 148-154
|
Physical Compatibility of Medications Used in Critically Ill Patients with Balanced Fluid Solutions
Wilder Alyson G, Foushee Jaime A, Fox Laura M, Navalle Jordan, Wright Adrienne M, Greer Megan A
|
May/Jun 2020
Pg. 238-241
|
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
|
Mar/Apr 2017
Pg. 160-163
|