Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Temozolomide Stability in Extemporaneously Compounded Oral Suspensions

Author(s):  Trissel Lawrence A, Zhang Yanping, Koontz Susannah E

Issue:  Sep/Oct 2006 - Dermatology
View All Articles in Issue

Page(s):  396-399

Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 1
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 2
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 3
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 4

Download in electronic PDF format for $75

Abstract:  Temozolomide, commercially available in capsules, is an oral alkylating agent used to treat brain tumors. The purpose of this study was to determine the pharmaceutical acceptability and chemical stability of temozolomide in two extemporaneously compounded suspension formulations prepared from the capsules. The temozolomide oral suspensions were prepared from 100-mg commercial capsules yielding a nominal temozolomide concentration of 10 mg/mL. The suspension vehicles selected for testing were an equal parts mixture of Ora-Plus and Ora-Sweet and an equal parts mixture of Ora-Plus and Ora-Sweet SF. The suspensions were packaged in amber plastic screw-cap prescription bottles, which were stored at 23°C for 21 days or 4°C for 60 days. Stability-indicating high-performance liquid chromatographic analysis revealed that the temozolomide concentration in both suspension vehicle combinations exhibited little or no loss for 60 days at 4°C. At 23°C, temozolomide losses were somewhat greater. In the Ora-Sweet formulation,

Related Keywords: Lawrence A. Trissel, BS, RPh, FASHP, Yanping Zhang, BS, Susannah E. Koontz, PharmD, BCOP, temozolomide, brain tumors, cancer chemotherapy, oral suspensions, liquid preparations, stability, storage, temperature, vehicles, formulation

Related Categories: CANCER AND AIDS, FORMULATIONS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, NEUROLOGY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions
Trissel Lawrence A
, Zhang Yanping, Koontz Susannah E
Sep/Oct 2006
Pg. 396-399

Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Kabiche Djamila
, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
Mar/Apr 2017
Pg. 160-163

Temozolomide 10-mg/mL Oral Liquid
Allen Loyd V Jr
Jul/Aug 2007
Pg. 336

Physicochemical and Microbiological Stability of Vancomycin 10-mg/mL Intravitreal Syringes
Bartoll Aaron Puplà
, Bellés Medall Maria Dolores, Peñarrocha Josep Edo, Escrig Laura Solaz, Clemente Ruben Eguren, Azuara Julia Bodega, Piqueres Raul Ferrando
Jul/Aug 2022
Pg. 330-335

Temozolomide 10 mg/mL in Oral Mix SF Suspension
Allen Loyd V Jr
May/Jun 2021
Pg. 235

Women's Oral Health: Is There a Hormonal Link?
Preckshot John
Jan/Feb 2004
Pg. 10-14

Basics of Compounding for the Treatment of Warts
Allen Loyd V Jr
Mar/Apr 2004
Pg. 126-129

Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt
Pramar Yashoda V
, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Sep/Oct 2021
Pg. 431-439

Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
Manchanda Arushi
, Laracy Melissa, Savji Taslim, Bogner Robin H
Jan/Feb 2018
Pg. 66-75

Stability Issues for Compounding Extemporaneously Prepared Oral Formulations for Pediatric Patients
Schotik Debora
Jan/Feb 2001
Pg. 9-12

Stability of Clopidogrel in Three Extemporaneously Compounded Oral Liquid Preparations
Yamreudeewong Weeranuj
, Dolence Eric Kurt, Teixeira M Glaucia
Sep/Oct 2011
Pg. 435-437

Development and Validation of a Stability-indicating High-performance Liquid Chromatographic Method for Quantification of Progesterone in Compounded Glycerinated Gelatin Troches
Burrows Anna C
, Yellepeddi Venkata Kashyap, Snyder Spencer, Wakefield Meagan, Jackson David, Huynh Johnny, Nguyen Khoa, Sayre Casey L
Jul/Aug 2019
Pg. 340-350

Stability of Oseltamivir in Various Extemporaneous Liquid Preparations
Ford Stephen M
, Kloesel Lawson G, Grabenstein John D
Mar/Apr 2007
Pg. 164-176

Extended Stability of Oxytocin in Common Infusion Solutions
Trissel Lawrence A
, Zhang Yanping, Douglass Kate, Kastango Eric
Mar/Apr 2006
Pg. 156-158

Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups
Kirk Loren
, Lewis Paul, Luu Yao, Brown Stacy
Mar/Apr 2016
Pg. 159-163

Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4
Espana B
, Joseph-Tornabène F, Jaquet Cécile, Perrot S, Prouillac C
Jul/Aug 2020
Pg. 327-336

Development of Extemporaneously Compounded Aripiprazole Oral Suspensions for Use in Children
Pramann Lance A
, Davidow Lawrence W, van Haandel Leon, Funk Ryan S
May/Jun 2016
Pg. 257-261

Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride during Simulated Y-site Administration
Trissel Lawrence A
, Zhang Yanping
Jul/Aug 2005
Pg. 320-322

Pediatric Compounding: Coloring Outside the Lines
Preckshot John
Jan/Feb 2001
Pg. 6-8

Stability of Two Concentrations of Tiagabine in an Extemporaneously Compounded Suspension
Haase Mark R
, Khan Mansoor A, Bonilla Jeremiah
Nov/Dec 2003
Pg. 485-489

Return to Top