Temozolomide Stability in Extemporaneously Compounded Oral Suspensions
Author(s): Trissel Lawrence A, Zhang Yanping, Koontz Susannah E
Issue: Sep/Oct 2006 - Dermatology
View All Articles in Issue
Page(s): 396-399
Download in electronic PDF format for $65
Abstract: Temozolomide, commercially available in capsules, is an oral alkylating agent used to treat brain tumors. The purpose of this study was to determine the pharmaceutical acceptability and chemical stability of temozolomide in two extemporaneously compounded suspension formulations prepared from the capsules. The temozolomide oral suspensions were prepared from 100-mg commercial capsules yielding a nominal temozolomide concentration of 10 mg/mL. The suspension vehicles selected for testing were an equal parts mixture of Ora-Plus and Ora-Sweet and an equal parts mixture of Ora-Plus and Ora-Sweet SF. The suspensions were packaged in amber plastic screw-cap prescription bottles, which were stored at 23°C for 21 days or 4°C for 60 days. Stability-indicating high-performance liquid chromatographic analysis revealed that the temozolomide concentration in both suspension vehicle combinations exhibited little or no loss for 60 days at 4°C. At 23°C, temozolomide losses were somewhat greater. In the Ora-Sweet formulation,
Related Keywords:
Lawrence A. Trissel, BS, RPh, FASHP, Yanping Zhang, BS, Susannah E. Koontz, PharmD, BCOP, temozolomide, brain tumors, cancer chemotherapy, oral suspensions, liquid preparations, stability, storage, temperature, vehicles, formulation
Related Categories:
CANCER AND AIDS, FORMULATIONS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, NEUROLOGY
Printer-Friendly Version
Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions
Trissel Lawrence A, Zhang Yanping, Koontz Susannah E
|
Sep/Oct 2006
Pg. 396-399
|
Basics of Compounding for the Treatment of Warts
Allen Loyd V Jr
|
Mar/Apr 2004
Pg. 126-129
|
Extended Stability of Oxytocin in Common Infusion Solutions
Trissel Lawrence A, Zhang Yanping, Douglass Kate, Kastango Eric
|
Mar/Apr 2006
Pg. 156-158
|
Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride during Simulated Y-site Administration
Trissel Lawrence A, Zhang Yanping
|
Jul/Aug 2005
Pg. 320-322
|
Compatibility and Stability of Aloxi (Palonosetron Hydrochloride) Admixed With Dexamethasone Sodium Phosphate
Trissel Lawrence A, Zhang Yanping
|
Sep/Oct 2004
Pg. 398-403
|
Oral Liquid Vehicles, Featured Excipient:
Allen Loyd V Jr
|
Jan/Feb 2001
Pg. 65-67
|
Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction.
Trissel Lawrence A, Zhang Yanping
|
May/Jun 2004
Pg. 231-235
|
Physicochemical and Microbiological Stability of Vancomycin 10-mg/mL Intravitreal Syringes
Bartoll Aaron Puplà, Bellés Medall Maria Dolores, Peñarrocha Josep Edo, Escrig Laura Solaz, Clemente Ruben Eguren, Azuara Julia Bodega, Piqueres Raul Ferrando
|
Jul/Aug 2022
Pg. 330-335
|
Development and Validation of a Stability-indicating High-performance Liquid Chromatographic Method for Quantification of Progesterone in Compounded Glycerinated Gelatin Troches
Burrows Anna C, Yellepeddi Venkata Kashyap, Snyder Spencer, Wakefield Meagan, Jackson David, Huynh Johnny, Nguyen Khoa, Sayre Casey L
|
Jul/Aug 2019
Pg. 340-350
|
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
|
Mar/Apr 2017
Pg. 160-163
|