Abstract

Temozolomide Stability in Extemporaneously Compounded Oral Suspensions

Author(s): Trissel Lawrence A, Zhang Yanping, Koontz Susannah E

Issue: Sep/Oct 2006 - Dermatology

Page(s): 396-399

Download in electronic PDF format for $75
  • Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 1
  • Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 2
  • Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 3
  • Temozolomide Stability in Extemporaneously Compounded Oral Suspensions Page 4

Abstract

Temozolomide, commercially available in capsules, is an oral alkylating agent used to treat brain tumors. The purpose of this study was to determine the pharmaceutical acceptability and chemical stability of temozolomide in two extemporaneously compounded suspension formulations prepared from the capsules. The temozolomide oral suspensions were prepared from 100-mg commercial capsules yielding a nominal temozolomide concentration of 10 mg/mL. The suspension vehicles selected for testing were an equal parts mixture of Ora-Plus and Ora-Sweet and an equal parts mixture of Ora-Plus and Ora-Sweet SF. The suspensions were packaged in amber plastic screw-cap prescription bottles, which were stored at 23°C for 21 days or 4°C for 60 days. Stability-indicating high-performance liquid chromatographic analysis revealed that the temozolomide concentration in both suspension vehicle combinations exhibited little or no loss for 60 days at 4°C. At 23°C, temozolomide losses were somewhat greater. In the Ora-Sweet formulation,

Related Keywords

  • temozolomide
  • brain tumors
  • cancer chemotherapy
  • oral suspensions
  • liquid preparations
  • stability
  • storage
  • temperature
  • vehicles
  • formulation

Related Categories

  • CANCER AND AIDS
  • FORMULATIONS
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • DOSAGE FORMS/DRUG CARRIERS
  • NEUROLOGY

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Sep/Oct 2006
Pg. 396-399
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions
Author(s): Trissel Lawrence A, Zhang Yanping, Koontz Susannah E
Jul/Aug 2007
Pg. 336
Temozolomide 10-mg/mL Oral Liquid
Author(s): Allen Loyd V Jr
Sep/Oct 2021
Pg. 431-439
Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt
Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Mar/Apr 2017
Pg. 160-163
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Author(s): Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
May/Jun 2021
Pg. 235
Temozolomide 10 mg/mL in Oral Mix SF Suspension
Author(s): Allen Loyd V Jr
Jan/Feb 2001
Pg. 65-67
Oral Liquid Vehicles, Featured Excipient:
Author(s): Allen Loyd V Jr
Jan/Feb 2001
Pg. 9-12
Stability Issues for Compounding Extemporaneously Prepared Oral Formulations for Pediatric Patients
Author(s): Schotik Debora
Mar/Apr 2004
Pg. 126-129
Basics of Compounding for the Treatment of Warts
Author(s): Allen Loyd V Jr
Sep/Oct 2011
Pg. 435-437
Stability of Clopidogrel in Three Extemporaneously Compounded Oral Liquid Preparations
Author(s): Yamreudeewong Weeranuj, Dolence Eric Kurt, Teixeira M Glaucia
Jul/Aug 2017
Pg. 322-329
Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox)
Author(s): Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel
Sep/Oct 2003
Pg. 389-393
Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride
Author(s): Alexander Kenneth S, Thyangarajapuram N
Mar/Apr 1997
Pg. 128-131
Stability of Allopurinol Suspension Compounded from Tablets
Author(s): Alexander Kenneth S, Davar Nipun, Parker Gordon A
Mar/Apr 2014
Pg. 169-174
Preparation and Stability Evaluation of Extemporaneous Oral Suspension of Valsartan Using Commercially Available Tablets
Author(s): Zaid Abdel Naser, Assali Mohyeddin, Qaddomi Aiman, Ghanem Mashhour, Zaaror Yara Abu
Jul/Aug 2015
Pg. 337-339
Stability of Prednisone in Oral Mix Suspending Vehicle
Author(s): Friciu Mihaela, Plourde Kevin, Leclair Grégoire, Danapoulos Panagiota, Savji Taslim
Jan/Feb 2018
Pg. 66-75
Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
Author(s): Manchanda Arushi, Laracy Melissa, Savji Taslim, Bogner Robin H
Sep/Oct 2024
Pg. 408-412
Stability of Allopurinol in Extemporaneously Compounded Oral Suspensions with Oral Mix and Oral Mix SF
Author(s): Friciu Mihaela, Cull Erica, Leclair Grégoire
May/Jun 2017
Pg. 251-254
Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes
Author(s): McHenry Adam R, Wempe Michael F, Rice Peter J
Jan/Feb 2023
Pg. 72-77
Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base
Author(s): Spennacchio Antonio, Lopedota Angela, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio
Jul/Aug 2020
Pg. 327-336
Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4
Author(s): Espana B, Joseph-Tornabène F, Jaquet Cécile, Perrot S, Prouillac C
Sep/Oct 2015
Pg. 428-431
Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Author(s): Nahata Milap C