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Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland

Author(s):  Suvikas-Peltonen Eeva, Palmgren Joni, Häggman Verner, Celikkayalar Ercan, Manninen Raija, Airaksinen Marja

Issue:  Nov/Dec 2017 - Volume 21, Number 6
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Page(s):  518-529

Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 1
Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 2
Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 3
Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 4
Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 5
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Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 10
Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 11
Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland Page 12

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Abstract:  On the hospital wards in Finland, nurses generally reconstitute intravenous medicines, such as antibiotics, analgesics, and antiemetics prescribed by doctors. Medicine reconstitution is prone to many errors. Therefore, it is important to identify incorrect practices in the reconstitution of medicine to improve patient safety in hospitals. The aim of this study was to audit the compounding and reconstituting of intravenous medicines on hospital wards in a secondary-care hospital in Finland by using an assessment tool and microbiological testing for identifying issues posing patient safety risks. A hospital pharmacist conducted an external audit by using a validated 65-item assessment tool for safe-medicine compounding practices on 20 wards of the selected hospital. Also, three different microbiological samples were collected to assure the aseptics. Practices were evaluated using a four-point rating scale of “never performed,” “rarely performed,” “often performed,” and “always performed,” and were based on observation and interviews with nurses or ward pharmacists. In addition, glove-, settle plate-, and media fill-tests were collected. Associations between microbial sample results and audit-tool results were discussed. Altogether, only six out of the 65 items were fully implemented in all wards; these were related to logistic practices and quality assurance. More than half of the wards used incorrect practices (“rarely performed” or “never performed”) for five items. Most of these obviated practices related to aseptic practices. All media-fill tests were clean but the number of colony forming units in glove samples and settle- plate samples varied from 0 to >100. More contamination was found in wards where environmental conditions were inadequate or the use of gloves was incorrect. Compounding practices were [mostly] quite well adapted, but the aseptic practices needed improvement. Attention should have been directed particularly to good aseptic techniques and compounding environment on the wards. These results can be used for updating the guidelines and for training nurses involved in compounding.

Related Keywords: Eeva Suvikas-Peltonen, MSc Pharm, Joni Palmgren, PhD, Verner Häggman, Pharmacy Student, Ercan Celikkayalar, MSc Pharm, Raija Manninen, PhD, Marja Airaksinen, PhD, Finland, reconstitution errors, drug safety, parenteral administration, hospital pharmacy, aseptic technique, microbial contamination, quality control, nurse training, nursing, quality assurance, assessment tool, compounding practice audit, compounded sterile preparations

Related Categories: PARENTERALS, PEER-REVIEWED, QUALITY CONTROL, HOSPITAL PHARMACY

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