Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy

Author(s):  Palma Elisabetta, Bufarini Celestino

Issue:  Sep/Oct 2014 - Volume 18, Number 5
View All Articles in Issue

Page(s):  358-364

Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy Page 1
Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy Page 2
Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy Page 3
Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy Page 4
Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy Page 5
Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy Page 6
Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy Page 7

Download in electronic PDF format for $75

Abstract:  In 2005, the Pharmacy Department of the University Hospital of Ancona began collaboration with the engineers of the Loccioni group in order to realize a fully automated system for the preparation of cytostatic drugs, which could be safe for both healthcare workers and patients. At present, the cytotoxic laboratory of Ancona is equipped with two robots and one Class II biological-safety cabinet. The introduction of the robots in the cytotoxic laboratory has increased both efficiency and safety of the working process. The drug-preparation process begins when the pharmacist confirms the medical prescription (exact posology, modalities of reconstitution), and starts the preparation cycle. The sterility of the preparations is monthly tested in collaboration to the local microbiology laboratory. All preparations’ results were germ-free even after storage at room temperature for two weeks. The dose accuracy is verified by visual and gravimetric independent systems. Drug concentration errors exceeding the limit of 10% fixed by the Italian Pharmacopeia were found only in 1.1% of the preparations. The average dose error was 0.8% (standard deviation 1.7%).

Related Keywords: Elisabetta Palma, PhD, MSN, RN, Celestino Bufarini, PharmD, University of Ancona, Italy, chemotherapy, cancer therapy, worker safety, workplace safety, cytotoxic drugs, biological safety cabinet, automation, automated drug preparation, robot, aseptic compounding, compounded sterile preparations, medication errors, drug contamination, packaging

Related Categories: CANCER AND AIDS, ENVIRONMENTAL , STERILE PREPARATIONS, TECHNOLOGY, QUALITY CONTROL, HOSPITAL PHARMACY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy
Palma Elisabetta
, Bufarini Celestino
Sep/Oct 2014
Pg. 358-364

Safety Standards in Pharmaceutical Compounding, Part 3: Fire Safety
Allen W Chris
, Greeson Nicole MH, Mixon William
Nov/Dec 2020
Pg. 451-458

Compounding Enclosures: Ensuring Safety During the Preparation of Sterile and Nonsterile Formulations
Ashe Krystina
, Baskett Dustin
Sep/Oct 2018
Pg. 387-398

Safety Standards in Pharmaceutical Compounding, Part 1: The Occupational Safety and Health Administration
Greeson Nicole MH
, Mixon William, Allan W Chris
Jul/Aug 2020
Pg. 270-276

Safety Standards in Pharmaceutical Compounding, Part 2: A Closer Look at Agency Information, Oversight, and Assistance
Greeson Nicole MH
, Mixon William, Allan W Chris
Sep/Oct 2020
Pg. 371-379

Complying with Occupational Safety and Health Administration Regulations: A Guide for Compounding Pharmacists
Mixon Bill
, Nain John
May/Jun 2013
Pg. 182-190

Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland
Suvikas-Peltonen Eeva
, Palmgren Joni, Häggman Verner, Celikkayalar Ercan, Manninen Raija, Airaksinen Marja
Nov/Dec 2017
Pg. 518-529

How to Develop and Maintain a Hazardous Drug List
Dillon L Rad
May/Jun 2019
Pg. 182-186

Study of Microbiological Safety of 25 Oncology Drugs After Multiple Uses in Aseptic Conditions
Roy Julie
, Brault Julie, Joran Pierre, Metrop Raphael, Hildgen Patrice
Sep/Oct 2011
Pg. 428-434

Basics of Compounding for the Treatment of Warts
Allen Loyd V Jr
Mar/Apr 2004
Pg. 126-129

Basics of Compounding for Hazardous Drugs, Part 2: Regulation and Sources of Contamination
Allen Loyd V Jr
Nov/Dec 2006
Pg. 446-448

Quality Control: (Material) Safety Data Sheets
Allen Loyd V Jr
Mar/Apr 2017
Pg. 118-124

Safety and Efficacy Studies, Pharmacy Education, and the NASEM Report on Compounded Topical Pain Creams
Allen Loyd V Jr
Sep/Oct 2020
Pg. 356

Pharmacies on the Frontline: Responding to the COVID-19 Pandemic
McElhiney Linda F
Jul/Aug 2020
Pg. 287-295

Quality Control Analytical Methods: A Growing Codependency: Compounding Pharmacy and Safety
Prince Bryan
, Lundeval Jeremy
Nov/Dec 2013
Pg. 485-489

Compounding Using Hazardous Drugs
Lau Kellie
Jul/Aug 2000
Pg. 261-263

Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes
de Wilde Sofieke
, Crul Mirjam, Breukels Oscar
Mar/Apr 2023
Pg. 154-159

Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal)
Garrigue Philippe
, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand
Mar/Apr 2016
Pg. 148-154

Safer Sterile Compounding: Choosing and Using Disinfectants for the Cleanroom
Kastango Eric S
, Douglass Kate, Patel Kedar, Givehchi Babak, Brister Paul, Postlewaite Jay, Taraban Laura
Jul/Aug 2015
Pg. 268-278

Determining Whether a Substance is Legal to Compound with Under Section 503A of the FDCA
Cabaleiro Joe
Sep/Oct 2021
Pg. 358-362

Return to Top