Stability of Phenytoin Sodium Suspensions for the Treatment of Open Wounds

Rhodes, Richard S; Kuykendall, Jim R; Heyneman, Catherine A; May, Matthew P; Bhushan, Alok

Abstract

Stability of Phenytoin Sodium Suspensions for the Treatment of Open Wounds

Author(s): Rhodes Richard S, Kuykendall Jim R, Heyneman Catherine A, May Matthew P, Bhushan Alok

Issue: Jan/Feb 2006 - Sports Medicine

View All Articles in Issue

Page(s): 74-78

Download in electronic PDF format for $75

Abstract

The objective of this study was to evaluate the stability of two phenytoin sodium suspensions in 0.9% sodium chloride solution for use in noninstitutional settings (where pharmacies are not present) to dispense phenytoin on a daily basis. A generic extended phenytoin sodium (Mylan) and a name brand phenytoin sodium (Dilantin) in suspension form were evaluated. Both suspensions were first assessed for degradation during frozen storage at designated time intervals. Frozen samples were compared with freshly prepared samples. The chemical stability of phenytoin concentrations in the samples was assessed by using a high-performance liquid chromatography analytical technique. During the course of the experiment, the samples showed no crystallization and the pH remained in a range of 10.6 to 10.73. The suspensions were tested for contamination. The results show that Dilantin and Mylan suspensions remained stable and free of contamination. Suspensions of phenytoin sodium in 0.9% sodium chloride solution are stable at room temperature for at least 2 weeks.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Jul/Aug 2004 Pg. 269-274	Current Topical Treatments in Wound Healing - Part 1 Author(s): Helmke Christopher D
Jan/Feb 2006 Pg. 74-78	Stability of Phenytoin Sodium Suspensions for the Treatment of Open Wounds Author(s): Rhodes Richard S, Kuykendall Jim R, Heyneman Catherine A, May Matthew P, Bhushan Alok
Mar/Apr 2002 Pg. 92-95	Options in Wound Care Author(s): Kincaid Michele R
Jul/Aug 2020 Pg. 278-281	Compounding Pearls -- Wound Care: Diabetic Foot Ulcers, Part 2 Author(s): Riepl Mike
Jul/Aug 2004 Pg. 265-267	Case Report: Wound Care of a Diabetic Foot Ulcer Author(s): Wynn Tom
Nov/Dec 2022 Pg. 480-488	A Compendium of Compounding Agents and Formulations, Part 6: Additional Preparations for Refractory Dermal-wound Healing Author(s): Riepl Mike
May/Jun 2020 Pg. 182-186	Compounding Pearls -- Wound Care: Diabetic Foot Ulcers, Part 1 Author(s): Riepl Mike
Mar/Apr 2022 Pg. 94-98	A Compendium of Compounding Agents and Formulations, Part 2: Metronidazole, Misoprostol, and Phenytoin Author(s): Riepl Mike
Jul/Aug 2007 Pg. 333	Phenytoin Sodium 20-mg/mL Topical Suspension Author(s): Allen Loyd V Jr
May/Jun 2009 Pg. 196-213	Missives from Iraq: Compounding the Theatre of War--Phenytoin Solution Heals Severe Refractory Wounds: An Anecdotal Report Author(s): Muller George, Hall Linda A, Stovall Audrey, Peters Susan H, Vail Jane
Jul/Aug 2000 Pg. 301	Lidocaine HCl 2%, Misoprostol 0.003% and Phenytoin 2.5% Topical Gel for Decubitus Ulcers Author(s): Allen Loyd V Jr
Jul/Aug 2020 Pg. 282-285	Compounding Pearls -- Wound Care: Burn Healing, Part 2 Author(s): Riepl Mike
Jan/Feb 2009 Pg. 25-29	Compounding with Sucralfate for the Treatment of External Wounds Author(s): Wynn Tom, Williams LaVonn A
Jan/Feb 2017 Pg. 22-27	Case Report: Diabetic Foot Ulcer Infection Treated with Topical Compounded Medications Author(s): Agbi Kelechi E, Carvalho Maria, Phan Ha, Tuma Cristiane
May/Jun 2003 Pg. 176-178	Case Report: Topical Gel for the Treatment of a Refractory Leg Ulcer Author(s): Israel Alan
Sep/Oct 2021 Pg. 372-377	Compounding Pearls--Wound Care: Drugs and Formulations for Dermal Healing, Part 3: The Roles of Nitric Oxide, Sildenafil, and Naltrexone Author(s): Riepl Mike
Sep/Oct 2022 Pg. 364-368	A Compendium of Compounding Agents and Formulations, Part 5: Timolol and Beta-glucans Author(s): Riepl Mike
Nov/Dec 2020 Pg. 501-508	Drug-release Assessment of Compounded Topical Nifedipine and Diltiazem in Commonly Used Bases for Wound Healing Author(s): Teimouri Arezou, Yeung Pollen, Agu Remigius U
Jul/Aug 2003 Pg. 266-270	Sensitization Therapy for Warts Author(s): Kuntz Rachael
Sep/Oct 2004 Pg. 354-357	Current Topical Treatments in Wound Healing - Part 2 Author(s): Helmke Christopher D