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Abstract:  Persistent diabetic foot ulcers can be difficult to treat. Success in doing so is based on understanding the differences between chronic- and acute-wound healing in general, the unique characteristics of those painful ulcers, and methods of treating them with pharmacotherapy that is safe and effective, especially in patients with multiple health challenges. When conventional treatments that rely on standard drug combinations, doses, and dosage forms do not promote healing in such cases, a pharmaceutical compound that can be customized in those respects may do so. In this article, which is the second in a 2-part series, those issues are addressed and formulations shown to be effective in resolving chronic wounds are provided. To my knowledge, at the time of this writing, the drugs in those compounds are not available, either alone or in combination, in any commercially available product designed for topical application to a healing wound.

Related Keywords: Mike Riepl, RPh, diabetic foot ulcers, diabetes, wound care, wound healing, chronic wounds, reepithelialization, acute wounds, formulations, drug combinations, phenytoin, misoprostol, insulin, naltrexone, nonhealing wounds, topical preparations, extracellular matrix, collagen, granulation, prostaglandin receptor EP2, dendritic cells, inflammation, proinflammatory cytokines, keratinocyte migration, liothyronine sodium, simvastatin

Related Categories: DERMATOLOGY, DIABETES, FORMULATIONS, WOUND CARE, DOSAGE FORMS/DRUG CARRIERS, NEUROLOGY

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