The Compatibility of Common Respiratory Therapy Drug Combinations
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Abstract: Respiratory therapists are being asked to take care of sicker
patients and in many cases this requires the administration of
multiple inhalation drugs. In an effort to reduce the workload,
therapists are combining drugs in the same nebulizer. Pharmacists
also are being asked to prepare unit dose preparations
of combined inhalation drugs without physical compatibility
data. It is theorized that some drug combinations precipitate
and that these particulates are ultimately inhaled into the patient’s
lungs. These particulates can cause locally high concentrations
of drug resulting in tissue irritation or actual
occlusion of the airway. This study tested the physical compatibility
of 22 common combinations used in our hospital and
found 19 of these combinations incompatible. Due to the potential
of precipitation,we recommend that inhalation drugs
not be routinely combined without specific compatibility data.
Related Keywords:
Respiratory therapy, drug combinations, incompatibility of, Respiratory therapy, precipitation of drugs in
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