Abstract

Novel Approaches to Topical Psoriasis Therapy

Author(s): Koyama Gregory, Liu Jenny, Scaffidi Alyse, Khazraee Maryam, Epstein Benjamin

Issue: Sep/Oct 2015 - Volume 19, Number 5

Page(s): 357-365

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Abstract

Topical corticosteroids are the cornerstone of treatment for the majority of psoriasis patients. However, potential side effects of topical corticosteroids (i.e., cutaneous atrophy, telangiectasias, hypothalamic-pituitary axis suppression), coupled with the complex pathophysiology of psoriasis and the individual needs/preferences of psoriasis patients, represent a few of the limitations associated with topical corticosteroid monotherapy. While the combination of some agents with varying mechanisms of action has proven to be an effective strategy for improving efficacy and reducing concomitant drug application, others have displayed less efficacy, harm, and/or reduced cost-effectiveness. The purpose of this article is to review novel topical therapeutic combinations for the management of psoriasis and explore the role compounding pharmacies can have in providing healthcare providers and patients with effective and affordable alternative psoriasis therapies.

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