Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid

Author(s):  McElhiney Linda F

Issue:  Nov/Dec 2004 - Endotoxin
View All Articles in Issue

Page(s):  458-460

A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid Page 1
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid Page 2
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid Page 3

Download in electronic PDF format for $65

Abstract:  Most commercially available oral liquid preparations of ascorbic acid contain propylene glycol. At high doses, this common food and drug additive is know to increase the risk of serum hyperosmolality, with a marked osmolar gap, lactic acidosis, seizures, and cardiac arrhythmias. This is a particular danger in children. Concern about propylene glycol toxicity prompted the World Health Organization to establish a maximum daily dose of 25 mg/kg/day, but the toxic dose is not known. A stable ascorbic acid preparation can be formulated without propylene glycol. A formula and method are provided.

Related Keywords: Linda F. McElhiney, PharmD, RPh, burns, burn units, vitamin C, children, propylene glycol, toxic effects, liquid formulations, adverse effects, ascorbic acid syrup, formulation: ascorbic acid 100-mg/mL syrup

Related Categories: EXCIPIENTS, FORMULATIONS, PEDIATRICS

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid
McElhiney Linda F
Nov/Dec 2004
Pg. 458-460

Basics of Compounding for Cough
Allen Loyd V Jr
Nov/Dec 2004
Pg. 462-465

Ascorbic Acid 250-mg/mL Injection
Allen Loyd V Jr
May/Jun 2012
Pg. 240

Ascorbic Acid 10% in Anhydrous PEG ointment
Allen Loyd V Jr
Jan/Feb 2022
Pg. 53

L-Arginine and Ascorbic Acid for Diabetic Foot Ulcers
Gorman Shellie
Mar/Apr 2000
Pg. 94-96

Ascorbic acid 5% Topical Microemulsion
Allen Loyd V Jr
Sep/Oct 2022
Pg. 423

Compounding in the Pharmacy Curriculum: Beyond the Basics
Hinkle Amanda R
, Newton Gail D
May/Jun 2004
Pg. 181-185

Acidifying Agents, Featured Excipient:
Allen Loyd V Jr
Jul/Aug 1999
Pg. 309-310

Compounding Pearls -- Wound Care: Burn Healing, Part 1
Riepl Mike
May/Jun 2020
Pg. 188-193

Trichloroacetic Acid 20%, Salicylic Acid 20%, Lactic Acid 10% in Flexible Collodion
Allen Loyd V Jr
Sep/Oct 2015
Pg. 410