Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid

Author(s):  McElhiney Linda F

Issue:  Nov/Dec 2004 - Endotoxin
View All Articles in Issue

Page(s):  458-460

A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid Page 1
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid Page 2
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid Page 3

Download in electronic PDF format for $75

Abstract:  Most commercially available oral liquid preparations of ascorbic acid contain propylene glycol. At high doses, this common food and drug additive is know to increase the risk of serum hyperosmolality, with a marked osmolar gap, lactic acidosis, seizures, and cardiac arrhythmias. This is a particular danger in children. Concern about propylene glycol toxicity prompted the World Health Organization to establish a maximum daily dose of 25 mg/kg/day, but the toxic dose is not known. A stable ascorbic acid preparation can be formulated without propylene glycol. A formula and method are provided.

Related Keywords: burns, burn units, vitamin C, children, propylene glycol, toxic effects, liquid formulations, adverse effects, ascorbic acid syrup, formulation: ascorbic acid 100-mg/mL syrup

Related Categories: EXCIPIENTS, FORMULATIONS, PEDIATRICS

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
A Need for Propylene Glycol-Free Ascorbic Acid Oral Liquid
McElhiney Linda F
Nov/Dec 2004
Pg. 458-460

Ascorbic Acid 10% in Anhydrous PEG ointment
Allen Loyd V Jr
Jan/Feb 2022
Pg. 53

Ascorbic Acid 250-mg/mL Injection
Allen Loyd V Jr
May/Jun 2012
Pg. 240

Ascorbic acid 5% Topical Microemulsion
Allen Loyd V Jr
Sep/Oct 2022
Pg. 423

Acidifying Agents, Featured Excipient:
Allen Loyd V Jr
Jul/Aug 1999
Pg. 309-310

Basics of Compounding for Cough
Allen Loyd V Jr
Nov/Dec 2004
Pg. 462-465

Trichloroacetic Acid 20%, Salicylic Acid 20%, Lactic Acid 10% in Flexible Collodion
Allen Loyd V Jr
Sep/Oct 2015
Pg. 410

Kinetics of Tetracaine Solvolysis in Propylene Glycol
McPherson Timothy B
, Neumann William L, Goolsby Michael, Kolling William M
Jul/Aug 2018
Pg. 329-334

L-Arginine and Ascorbic Acid for Diabetic Foot Ulcers
Gorman Shellie
Mar/Apr 2000
Pg. 94-96

Ascorbic Acid 10% Ophthalmic Solution
Allen Loyd V Jr
May/Jun 1998
Pg. 224

Compounding in the Pharmacy Curriculum: Beyond the Basics
Hinkle Amanda R
, Newton Gail D
May/Jun 2004
Pg. 181-185

Folic Acid 1-mg/mL Oral Liquid
Allen Loyd V Jr
May/Jun 2007
Pg. 244

Oral Liquid Vehicles, Featured Excipient:
Allen Loyd V Jr
Jan/Feb 2001
Pg. 65-67

Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Zhang Yan-ping
, Trissel Lawrence A
Mar/Apr 1997
Pg. 132-134

Omeprazole 1 mg/mL and 4 mg/mL in Humco Flavor Sweet Sugar-Free Oral Liquid
Allen Loyd V Jr
Jan/Feb 2019
Pg. 58

Need for Appropriate Formulations for Children: The National Institute of Child Health and Human Development--Pediatric Formulations Initiative, Part 2
Giacoia George P
, Taylor-Zapata Perdita, Mattison Donald
May/Jun 2007
Pg. 220-225

Physicochemical Stability of Compounded Creams Containing alpha-Hydroxy Acids
de Villiers Melgardt M
, Narsai Kirti, van der Watt Jakkie G
Jan/Feb 2000
Pg. 72-75

Lisinopril 1-mg/mL, Sodium Citrate, and Citric Acid Oral Liquid
Allen Loyd V Jr
Sep/Oct 2006
Pg. 386

Gastrointestinal Mucositis: Focus on the Treatment of the Effects of Chemotherapy and Radiotherapy on the Rectum
Zur Eyal
Mar/Apr 2012
Pg. 117-124

Compounding Pearls -- Wound Care: Burn Healing, Part 1
Riepl Mike
May/Jun 2020
Pg. 188-193

Return to Top