Physicochemical Stability of Compounded Creams Containing alpha-Hydroxy Acids

de, Villiers Melgardt M; Narsai, Kirti; van, der Watt Jakkie G

Abstract

Physicochemical Stability of Compounded Creams Containing alpha-Hydroxy Acids

Author(s): de Villiers Melgardt M, Narsai Kirti, van der Watt Jakkie G

Issue: Jan/Feb 2000 - Compounding for Pain Management

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Page(s): 72-75

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Abstract

The stability of creams containing the a-hydroxy acids (AHAs), lactic acid and glycolic acid, extemporaneously added to aqueous cream, BP or hydrophilic ointment, USP, and subjected to five freeze-thaw cycles ranging from –4 to 40°C was studied. The pH, viscosity, spreadibility, density, appearance and potency were measured after each freeze-thaw cycle. Compounding with hydrophilic ointment, USP produced the most stable creams; but the addition of the AHAs caused a significant decrease in preservative levels. The preservatives methylparaben and propylparaben were not hydrolyzed in the hydrophilic creams if the AHA was partially neutralized to a pH above 3.5.

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