Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection

Author(s):  Zhang Yan-ping, Trissel Lawrence A

Issue:  Mar/Apr 1997 - Pediatric Care
View All Articles in Issue

Page(s):  132-134

Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Page 1
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Page 2
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Page 3

Download in electronic PDF format for $75

Abstract:  The purpose of this study was to determine the stability of aminocaproic acid 10 and 100 mg/mL admixed in 5% dextrose injection and 0.9% sodium chloride injection in polyvinyl chloride bags over periods up to seven days at 4° and 23°C.

The aminocaproic acid 250-mg/mL injection was filtered and admixed in filtered 5% dextrose injection and 0.9% sodium chloride injection to yield nominal aminocaproic acid concentrations of 10 and 100 mg/mL. Evaluations were performed initially and after one, three, and seven days of storage for physical and chemical stability. The admixtures were evaluated for physical stability using visual observation in normal fluorescent room light and a high-intensity monodirectional light beam, as well as electronic measurement of turbidity and particle content. The chemical stability was evaluated by using a stability-indicating high performance liquid chromatography (HPLC) analytical technique.

Aminocaproic acid admixtures were clear and colorless. However, the admixtures in 5% dextrose injection developed a slight yellowish discoloration after 24 hours at 23° C. This discoloration did not indicate substantial loss of aminocaproic acid. The HPLC evaluations found that an aminocaproic acid potency of at least 98% was retained throughout seven days in all solutions at both 4° and 23°C.

Related Keywords: Aminocaproic acid injection, admixtures of, Aminocaproic acid injection, stability of during storage, Aminocaproic acid injection, effect of temperature on during storage

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Zhang Yan-ping
, Trissel Lawrence A
Mar/Apr 1997
Pg. 132-134

Aminocaproic Acid 250-mg/mL Injection
Allen Loyd V Jr
Sep/Oct 2013
Pg. 415

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection
Gupta Vishnu D
, Bailey RE
Jan/Feb 2000
Pg. 66-68

Aminocaproic Acid 250-mg/mL Oral Solution
Allen Loyd V Jr
Sep/Oct 2015
Pg. 404

Acidifying Agents, Featured Excipient:
Allen Loyd V Jr
Jul/Aug 1999
Pg. 309-310

Stability of Cefepime Hydrochloride Dextrose in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Gupta Vishnu D
, Maswoswe J, Bailey RE
Nov/Dec 1997
Pg. 435-436

Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs.
Xu Quanyun A
, Trissel Lawrence A, Pham Lien
May/Jun 2004
Pg. 228-230

Stability of Cefmetazole Sodium in 5% dextrose Injection and 0.9% Sodium Chloride Injection
Gupta Vishnu D
, Maswoswe J, Bailey RE
May/Jun 1997
Pg. 208-209

Jet Injection Devices for the Needle-free Administration of Compounds, Vaccines, and Other Agents
Logomasini Mark A
, Stout Richard R, Ron Marcinkoski
Jul/Aug 2013
Pg. 270-280

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Sep/Oct 2002
Pg. 388-390

Stability of Ketorolac Tromethamine in 5% Dextrose Injection and 0.9% Sodium Chloride Injections
Gupta Vishnu D
, Maswoswe J, Bailey RE
May/Jun 1997
Pg. 206-207

Stability of Milrinone Lactate 200 mcg/mL in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Wong Frances
, Gill Mark A
Mar/Apr 1998
Pg. 168-169

Drug Compatibility and Stability in Dextrose vs Saline
Newton David W
May/Jun 2011
Pg. 190-192

Stability of Neostigmine Methylsulfate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Nov/Dec 2002
Pg. 475-477

Trichloroacetic Acid 20%, Salicylic Acid 20%, Lactic Acid 10% in Flexible Collodion
Allen Loyd V Jr
Sep/Oct 2015
Pg. 410

Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions
Quay Irene
, Tan Edward
Jul/Aug 2001
Pg. 323-324

Stability of Ethacrynate Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
, Ling Jie
Jan/Feb 2001
Pg. 73-75

Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
, Ling Jie
Jan/Feb 2001
Pg. 75-77

Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Jan/Feb 2003
Pg. 68-70

Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Stewart James T
, Storms Meredith L, Warren Flynn W
Jul/Aug 2002
Pg. 308-310

Return to Top