Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Topical Therapy for Localized Hyperhidrosis

Author(s):  Glasnapp Andrew

Issue:  Jan/Feb 2001 - Compounding for Pediatric Patients
View All Articles in Issue

Page(s):  28-29

Topical Therapy for Localized Hyperhidrosis Page 1
Topical Therapy for Localized Hyperhidrosis Page 2

Download in electronic PDF format for $75

Abstract:  Up to 1% of the population suffers from hyperhidrosis, a disorder characterized by excessive sweating. Topical therapies may be the most practical and common treatment; however, many agents that have proven useful in clinical trials are not available as commercial products. The compounding pharmacist can significantly affect patient care by compounding unavailable items and suggesting alternative therapies to patients with refractory disease and in whom first-line agents have failed. The author discusses anticholinergics, aluminum chloride hexahydrate, local anesthetics and formaldehyde and related agents. Formulations for Glycopyrrolate 1% Cream (for 100 g) and for Methenamine 5% Lotion (for 100 mL) are provided. The author concludes that topical treatment should be the first line of therapy and that pharmacists can sometimes assist patients with agents such as glycopyrrolate and methenamine, which are effective and cause less skin irritation than aluminum chloride. In addition, pharmacists should advise patients with refractory hyperhidrosis that some treatment options are more permanent than topical therapy; severe cases may be treated with iontophoresis, botulinum toxin or surgery.

Related Keywords: aluminum chloride hexahydrate, antichoinergics, formaldehyde, hyperhidrosis, local anesthetics, localized hyperhidrosis

Related Categories: DERMATOLOGY

Printer-Friendly Version

Related Articles from IJPC
(Click for Abstract / Details / Purchase)
Topical Therapy for Localized Hyperhidrosis
Glasnapp Andrew
Jan/Feb 2001
Pg. 28-29

Topical Treatment of Primary Focal Hyperhidrosis, Part 2
Zur Eyal
Mar/Apr 2019
Pg. 94-104

Topical Treatment of Primary Focal Hyperhidrosis, Part 1
Zur Eyal
Jan/Feb 2019
Pg. 23-31

Novel Approaches to Topical Psoriasis Therapy
Koyama Gregory
, Liu Jenny, Scaffidi Alyse, Khazraee Maryam, Epstein Benjamin
Sep/Oct 2015
Pg. 357-365

Safe Use of Topical Local Anesthetic Medications for Pain Management
Epshteyn Mikhail G
, Pepin Steven M
May/Jun 2009
Pg. 218-219

Safe Use of Topical Local Anesthetic Medications for Pain Management
Epshteyn Mikhail G
, Pepin Steven M
Mar/Apr 2024
Pg. 118-119

Current Topical Treatments in Wound Healing - Part 1
Helmke Christopher D
Jul/Aug 2004
Pg. 269-274

Compounded Local Anesthetics to Minimize Pain from Medical Procedures
McElhiney Linda F
May/Jun 2008
Pg. 192-197

Aluminum Chloride 6.25% in Anhydrous Alcohol
Allen Loyd V Jr
Jan/Feb 2022
Pg. 52

Erratum: Zur E. Topical Treatment of Primary Focal Hyperhidrosis, Part 2. IJPC 2019; 23(2):94-104.
Jul/Aug 2019
Pg. 351

The Science Behind Hormone Replacement Therapy, Part 1
Wepfer Scott T
Nov/Dec 2001
Pg. 462-464

Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions
Quay Irene
, Tan Edward
Jul/Aug 2001
Pg. 323-324

Toxicities Associated with Topical Anesthetics
Bramwell Bethany L
Jan/Feb 2011
Pg. 41

Anesthetic Nasal Ointment
Allen Loyd V Jr
Jul/Aug 2011
Pg. 334

Iontophoresis Devices: Clinical Applications for Topical Delivery
Panus Peter
, Banga Ajay K
Nov/Dec 1997
Pg. 420-424

Head to Toe Solutions: A Quick Review of Current Therapies
Paoletti James E
Sep/Oct 2004
Pg. 345-352

Bioidentical Hormone Replacement Therapy, Part 3, A Review of
Wepfer Scott T
Mar/Apr 2002
Pg. 142-146

Curcumin 2% Topical Gel
Allen Loyd V Jr
Nov/Dec 2022
Pg. 509

Sensitization Therapy for Warts
Kuntz Rachael
Jul/Aug 2003
Pg. 266-270

Lidocaine Hydrochloride, Diphenhydramine Hydrochloride, Aluminum Hydroxide–Magnesium Hydrochloride–Simethicone Mouthwashes
Allen Loyd V Jr
Jan/Feb 2019
Pg. 54

Return to Top