Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Bioidentical Thyroid Replacement Therapy in Practice: Delivering a Physiologic T4-T3 Ratio for Improved Patient Outcomes with the Listecki-Snyder Protocol

Author(s):  Snyder Scott, Listecki Robert E

Issue:  Sep/Oct 2012 - Volume 16, Number 5
View All Articles in Issue

Page(s):  376-380

Note:  Electronic version includes supplemental material.

Bioidentical Thyroid Replacement Therapy in Practice: Delivering a Physiologic T4-T3 Ratio for Improved Patient Outcomes with the Listecki-Snyder Protocol Page 1
Bioidentical Thyroid Replacement Therapy in Practice: Delivering a Physiologic T4-T3 Ratio for Improved Patient Outcomes with the Listecki-Snyder Protocol Page 2
Bioidentical Thyroid Replacement Therapy in Practice: Delivering a Physiologic T4-T3 Ratio for Improved Patient Outcomes with the Listecki-Snyder Protocol Page 3
Bioidentical Thyroid Replacement Therapy in Practice: Delivering a Physiologic T4-T3 Ratio for Improved Patient Outcomes with the Listecki-Snyder Protocol Page 4
Bioidentical Thyroid Replacement Therapy in Practice: Delivering a Physiologic T4-T3 Ratio for Improved Patient Outcomes with the Listecki-Snyder Protocol Page 5

Download in electronic PDF format for $65

Abstract:  Effective thyroid replacement therapy may be elusive to some patients, and compounding pharmacists have an opportunity to deliver more effective therapy. Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th edition states that the body usually secretes T4:T3 in an 11:1 ratio but cautions against pursuing combined thyroid replacement due to the short halflife of T3 that necessitates multiple daily dosing; no commercial availability and lack of benefit were shown in trials.1 Commercial combinations of T4/T3 such as Armour Thyroid and Nature-Thyroid have a 4.22:1 T4:T3 ratio. Applying the same concept as bioidentical hormone replacement therapy, compounding pharmacists can deliver an 11:1 ratio using a commercial T4 product and taking into account oral bioavailability of each entity. The short half-life of T3 can be remedied by taking the patient’s daily T3 dose and dividing it into two slow-release capsules to be dosed every 12 hours.

Related Keywords: Scott Snyder, Robert Listecki, RPh, thyroid hormone deficiency, hypothyroidism, thyroid replacement, oral bioavailability, slow-release preparation, literature review, combination T4/T3 therapy, formulation, levothyroxine, T4, liothyronine, T3

Related Categories: FORMULATIONS, HRT, ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE, LITERATURE REVIEW, PATIENT ASSESSMENT

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Bioidentical Thyroid Replacement Therapy in Practice: Delivering a Physiologic T4-T3 Ratio for Improved Patient Outcomes with the Listecki-Snyder Protocol
Snyder Scott
, Listecki Robert E
Sep/Oct 2012
Pg. 376-380

The Science Behind Hormone Replacement Therapy, Part 1
Wepfer Scott T
Nov/Dec 2001
Pg. 462-464

Hypothyroidism: Optimizing Therapy with Slow-Release Compounded Thyroid Replacement
Milner Martin
Jul/Aug 2005
Pg. 268-273

Bioidentical Hormone Replacement Therapy, Part 3, A Review of
Wepfer Scott T
Mar/Apr 2002
Pg. 142-146

A Perspective on HRT for Women: Picking Up the Pieces After the Women's Health Initiative Trial - Part 1
Gillson George R
, Zava David T
Jul/Aug 2003
Pg. 250-256

Hormone Replacement Therapy: Part 1 - The Evolution of Hormone Treatment
Lorentzen Jean
Sep/Oct 2001
Pg. 336-338

Bioidentical Hormone Replacement Therapy, Part 2, A Review of
Wepfer Scott T
Jan/Feb 2002
Pg. 50-54

Menopausal Women's Access Path to Bioidentical Hormone Replacement Therapy: An Exploratory Study
Moro Doris
, Young Wendy, Stein Richard, Isaac Winston, Goodman Deborah
Mar/Apr 2010
Pg. 165-170

Thyroid Potency Calculations
Stack Bob
Jul/Aug 2010
Pg. 306-309

Using Serum Hormone Analysis to Develop Hormone Replacement Therapy Regimens - Part 2
Ford Gina
, Garcia Lea
Jan/Feb 2001
Pg. 52-54

Natural Progesterone in Natural Hormone Replacement Therapy, The Role of
Girouard Lorinda G
, Holm Richard C
May/Jun 2001
Pg. 218-220

Efficacy and Tolerability of Compounded Bioidentical Hormone Replacement Therapy
Vigesaa Kristy A
, Downhour Nathan P, Chui Michelle A, Cappellini Linda, Musil John D, McCallian Dennis J
Jul/Aug 2004
Pg. 313-319

The U.S. Food and Drug Administration Takes Aim at Compounded Thyroid Hormone
Brunner Scott
Jan/Feb 2023
Pg. 22-23

Satisfaction of Patients Using Bioidentical Hormones for Hormone Replacement Therapy
Santoro Filippo
Sep/Oct 2002
Pg. 378

Menopausal Symptom Relief and Side Effects Experienced by Women Using Bioidentical Hormone Replacement Therapy and Synthetic Conjugated Equine Estrogen and/or Progestin Hormone Replacement Therapy, Part 1
Deleruyelle Laura J
Sep/Oct 2016
Pg. 359-364

Menopausal Symptom Relief and Side Effects Experienced by Women Using Compounded Bioidentical Hormone Replacement Therapy and Synthetic Conjugated Equine Estrogen and/or Progestin Hormone Replacement Therapy, Part 2
Deleruyelle Laura J
Nov/Dec 2016
Pg. 447-454

Using Serum Hormone Analysis to Develop Hormone Replacement Therapy Regimens-Part 1
Ford Gina
, Garcia Lea
Nov/Dec 2000
Pg. 421-422

Guidelines for Consulting with Patients about Bioidentical Hormone Replacement Therapy
White Irene Q
Jul/Aug 2005
Pg. 266

Differentiation and Treatment of Hypothyroidism, Functional Hypothyroidism, and Functional Metabolism
Paoletti Jim
Nov/Dec 2008
Pg. 488-497

Natural Hormone Replacement Therapy: What It Is and What Consumers Really Want
Reed-Kane Dana
Sep/Oct 2001
Pg. 332-335

View Sample