Abstract

Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding

Author(s): Hoffmann Brittany, Carlson Christie, Rao Deepa A

Issue: Jul/Aug 2014 - Volume 18, Number 4

Page(s): 341-344

Download in electronic PDF format for $75
  • Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding Page 1
  • Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding Page 2
  • Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding Page 3
  • Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding Page 4

Abstract

The purpose of this work was to assess the use of food colors as a visual aid to determine homogeneous mixing in the extemporaneous preparation of capsules. Six different batches of progesterone slow-release 200-mg capsules were prepared by different mixing methods until visually determined as homogeneous based on yellow food coloring distribution in the preparation by the Central Iowa Compounding Pharmacy, Des Moines, Iowa. UV-Vis spectrophotometry was used to extract and evaluate yellow food coloring content in each of these batches and compared to an in-house, small-batch geometric dilution preparation of progesterone slow-release 200-mg capsules. Of the 6 batches tested, only one, which followed the principles of additive dilution and an appropriate mixing time, was both visually and quantitatively homogeneous in the detection of yellow food coloring. The use of food coloring alone is not a valid quality-assurance tool in determining homogeneous mixing. Principles of geometric and/or additive dilution and appropriate mixing times along with the food color can serve as a quality-assurance tool.

Related Keywords

  • food colors
  • visual aid
  • homogenous mixing
  • progesterone slow-release capsules
  • yellow food coloring
  • dye
  • homogenous dispersion
  • quality assurance

Related Categories

  • EXCIPIENTS
  • PEER-REVIEWED
  • QUALITY CONTROL
  • DOSAGE FORMS/DRUG CARRIERS

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Jul/Aug 2014
Pg. 341-344
Assessing the Use of Food Coloring as an Appropriate Visual Guide for Homogenously Mixed Capsule Powders in Extemporaneous Compounding
Author(s): Hoffmann Brittany, Carlson Christie, Rao Deepa A
Jul/Aug 2022
Pg. 309-315
Sterile Basics of Compounding: How to Implement a Robust Visual-inspection Program
Author(s): Summers Amy
May/Jun 2012
Pg. 190-195
I See Colors: Using Vital Dyes in Diagnosing Ophthalmic Disease
Author(s): McElhiney Linda F
Jul/Aug 2012
Pg. 304-309
Selection of Color Additives: A Regulatory View
Author(s): Kumar Anuj, Dureja Harish, Madan Anil K
Sep/Oct 2001
Pg. 401-405
Release of Morphine Sulfate from Compounded Slow-Release Capsules: The Effect of Formulation on Release
Author(s): Bogner Robin H, Szwejkowski Jessica, Houston Alana
Jan/Feb 2013
Pg. 10-22
Compounding Slow-release Capsules: A Comprehensive Review and an Excel Spreadsheet for Faster Calculation of Excipients
Author(s): Zur Eyal
Jul/Aug 2014
Pg. 293-300
Color Additives: Legislative Perspective in the United States, Europe, Australia, and India
Author(s): Kumar Anuj, Madan Anil K
Jul/Aug 2016
Pg. 351
View Sample
Discrepancies in the Law and the U.S. Food and Drug Administration Pharmacy Compounding Compliance Policy Guidelines
Author(s): Allen Loyd V Jr
Mar/Apr 2017
Pg. 95-102
U.S. Food and Drug Administration Inspections: Guide to a Successful Outcome for 503A Sterile Compounding Pharmacies
Author(s): Yoch Doug
Sep/Oct 2017
Pg. 418-425
Kinetic Analysis of Drug Release from Compounded Slow-release Capsules of Liothyronine Sodium (T3)
Author(s): Bakhteyar Hamid, Cassone Clayton, Kohan Hamed Gilzad, Sani Shabnam N
Jul/Aug 2015
Pg. 303-305
U.S. Food and Drug Administration Proposed Guidance Document: Compounding Animal Drugs from Bulk Substances
Author(s): Miller David G
Sep/Oct 2012
Pg. 434-437
Compounding of Slow-release Niacinamide Capsules: Feasibility and Characterization
Author(s): Radojkovic Branko, Milic Jela, Calija Bojan
Mar/Apr 2005
Pg. 157-164
In Vitro Evaluation of Extemporaneously Compounded Slow-Release Capsules Containing Morphine Sulfate or Oxycodone Hydrochloride
Author(s): Glowiak Dana L, Green Julie L, Bowman Bill J
Mar/Apr 2000
Pg. 154-155
Effect of Some Antioxidants on the Color Change of White Lotion
Author(s): Boonme Prapaporn
Jul/Aug 1999
Pg. 291-294
The Basics of Compounding: Compounding Special Capsules
Author(s): Allen Loyd V Jr
Jul/Aug 2007
Pg. 326-327
Standard Operating Procedure: U.S. Food and Drug Administration Inspection--Releasing a Sample to the U.S. Food and Drug Administration
Author(s): Kupiec Tom, Kemp Jesse
Jul/Aug 2014
Pg. 318-319
Basics of Compounding: Tips and Hints, Part 4: Lollipops/Lozenges, Gummy Bears, Patches, Flavoring/Coloring, Sweeteners, and Packaging
Author(s): Allen Loyd V Jr
Jan/Feb 2020
Pg. 62
Progesterone 100-mg, Melatonin 1-mg, and L-Theanine 200-mg Slow-Release Capsules
Author(s): Allen Loyd V Jr
Nov/Dec 2023
Pg. 474-481
Nonsterile Basics of Compounding: Using U.S. Food and Drug Administration-approved Commercial Products as Ingredients
Author(s): Allen Loyd V Jr
May/Jun 2016
Pg. 209-214
Basics of Compounding: Special Capsules
Author(s): Allen Loyd V Jr