IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures

Author(s):  Nahata Milap C

Issue:  Sep/Oct 2015 - Volume 19, Number 5
View All Articles in Issue

Abstract:  Extemporaneously prepared liquid dosage forms are needed to administer required medications in infants and young children. The goal of this study was to evaluate the stability of levothyroxine, doxycycline, hydrocortisone, and pravastatin in extemporaneously prepared suspensions stored in plastic prescription bottles under refrigeration and room temperature. Levothyroxine (25 mcg/mL), doxycycline (5 mg/mL), hydrocortisone (2 mg/mL), and pravastatin (10 mg/mL) were each prepared in two groups of suspensions. All of these suspensions were stored in plastic prescription bottles under refrigeration and at room temperature. Levothyroxine was stable for two weeks at 4°C but only one week at 25°C in both suspensions. Doxycycline was stable for two weeks in both suspensions at 4°C and 25°C. Hydrocortisone was stable for the entire two-week study period in both suspensions at both 4°C and 25°C. Pravastatin was stable for the one-week study period in both suspensions at both 4°C and 25°C. These results can be used to offer age-appropriate extemporaneously prepared medications to infants and young children when no suitable commercially available liquid formulations are available.

Related Keywords: Milap C. Nahata, PharmD, MS, levothyroxine, doxycycline, hydrocortisone, pravastatin, stability, storage temperature, oral suspension

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE, STORAGE

Printer-Friendly Version




Download in electronic PDF format for $35

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures Nahata Milap C Sep/Oct 2015 428-431 Buy
Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4 Espana B, Joseph-Tornabène F, Jaquet Cécile, Perrot S, Prouillac C Jul/Aug 2020 327-336 Buy
Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension Manchanda Arushi, Laracy Melissa, Savji Taslim, Bogner Robin H Jan/Feb 2018 66-75 Buy
Extended Stability of Morphine and Sildenafil for Oral Use in Infants and Young Children Nahata Milap C May/Jun 2016 247-249 Buy
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures Nahata Milap C Mar/Apr 2016 164-166 Buy
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel Mar/Apr 2017 160-163 Buy
Mean Kinetic Temperature for Controlled Room Temperature Drug Storage: Official Definitions and Example Calculations Newton David W Jul/Aug 2019 281-287 Buy
Quality Control and Physical and Chemical Stability of Hydrocortisone Oral Suspension: An Interlaboratory Study Santoveña A, Llabrés M, Fariña JB Sep/Oct 2010 430-435 Buy
Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox) Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel Jul/Aug 2017 322-329 Buy
Solid State Stability of Extemporaneously Prepared Levothyroxine Aliquots and Capsules Fortner Jeff, Salton Jason, Carlson Christie, Wheeler Rich, Cote Brianna, Rao Deepa Sep/Oct 2015 414-419 Buy