Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures

Author(s):  Nahata Milap C

Issue:  Mar/Apr 2016 - Volume 20, Number 2
View All Articles in Issue

Page(s):  164-166

Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures Page 1
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures Page 2
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures Page 3

Download in electronic PDF format for $75

Abstract:  The lack of commercially available liquid dosage forms for pediatric patients prompted this study. The objectives of our study were to determine the stability of zonisamide, amitriptyline, and glycopyrrolate in extemporaneously prepared oral suspensions in plastic prescription bottles. One group of suspensions was prepared in OraPlus:OraSweet (1:1) for each drug and stored either under refrigeration (4°C) or at room temperature (25°C). A second group of suspensions were compounded in 1% methylcellulose:simple syrup at a 1:10 proportion for zonisamide, amitriptyline, and glycopyrrolate; these suspensions were stored at either under refrigeration (4°C) or at room temperature (25°C). The drug concentrations were measured by the stability-indicating high-performance liquid chromatographic methods. The mean concentration of zonisamide (10 mg/mL) remained above 95% of the original concentration for 91 days in each group of suspensions at both 4°C and 25°C. The mean concentration of amitriptyline (20 mg/mL) was above 95% for 91 days in the suspensions containing OraPlus/OraSweet at both 4°C and 25°C. However, in the suspensions containing methylcellulose:simple syrup, the mean concentration of amitriptyline was about 95% for 42 days at 4°C and 28 days at 25°C. The mean concentration of glycopyrrolate (0.2 mg/mL) was above 95% in each group of suspensions during the 14-day study period. These data indicate that zonisamide, amitriptyline, and glycopyrrolate can be prepared extemporaneously as suspensions and stored in plastic prescription bottles for varying periods at 4°C and 25°C for use in pediatric patients.

Related Keywords: zonisamide, amitriptyline, glycopyrrolate, anticonvulsant agent, seizure disorder, depression, depressive disorder, tricyclic antidepressant, neuropathy, neuropathic pain, neuralgia, anticholinergic agent, acetylcholine, secretions, gastrointestinal ulcers, sweating, perspiration, hyperhidrosis, oral suspensions, liquid suspending vehicles, liquid dosage forms

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, STORAGE

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures
Nahata Milap C
Mar/Apr 2016
Pg. 164-166

Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Gupta Vishnu D
Sep/Oct 2003
Pg. 386-388

Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt
Pramar Yashoda V
, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Jul/Aug 2022
Pg. 342-351

Stability of an Oral Liquid Dosage Form of Glycopyrrolate Prepared from Tablets
Gupta Vishnu D
Nov/Dec 2001
Pg. 480-481

Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
Sep/Oct 2009
Pg. 445-446

Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Nahata Milap C
Sep/Oct 2015
Pg. 428-431

Glycopyrrolate Sorbitol Lollipops for Drooling: Two Case Reports
Agbi Kelechi E
, Carvalho Maria, Vieira-Banov Fabiana
Nov/Dec 2021
Pg. 464-467

Zonisamide 10-mg/mL Oral Suspension
Allen Loyd V Jr
Jan/Feb 2017
Pg. 65

Stability of Glycopyrrolate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Jan/Feb 2003
Pg. 65-67

Zonisamide 10 mg/mL in SyrSpend SF pH4
Allen Loyd V Jr
Nov/Dec 2019
Pg. 495

Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
Jul/Aug 2008
Pg. 372-374

Long-term Stability of Epitheliotropic Factors in Frozen Serum Eye Drops
Sahyoun Jean-Yves
, Cloutier Marc, Frenette Mathieu, Robert Marie-Claude
Jul/Aug 2022
Pg. 336-341

Compounded Analgesic Therapy for Disorders of Movement: Arthritis, Neuropathic Pain, and Postpolio Syndrome
Brown Scott
, Erickson Brian, Muller George, Bryant-Snure Susan J, Mestayer Richard F III
May/Jun 2010
Pg. 182-192

Long-term Stability of Vancomycin Hydrochloride in Oral Solution: The Brand Name Versus a Generic Product
Huvelle Sophie
, Godet Marie, Hecq Jean-Daniel, Gillet Patricia, Jamart Jacques, Galanti Laurence M
Jul/Aug 2016
Pg. 347-350

Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Gupta Vishnu D
May/Jun 2007
Pg. 259-261

Zonisamide 10-mg/mL Oral Suspension
Allen Loyd V Jr
Sep/Oct 2009
Pg. 437

Basics of Compounding for Disorders of the External Ear
Allen Loyd V Jr
Jan/Feb 2004
Pg. 46-48

Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jul/Aug 2008
Pg. 368-371

Amitriptyline 20 mg/mL in OraPlus:OraSweet Suspension
Allen Loyd V Jr
Nov/Dec 2017
Pg. 490

Amitriptyline Hydrochloride 10 mg/mL in SyrSpend SF pH4
Allen Loyd V Jr
Sep/Oct 2019
Pg. 407

Return to Top