Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Author(s): Gupta Vishnu D
Issue: Sep/Oct 2003 - After the Women's Health Initiative Trial
View All Articles in Issue
Page(s): 386-388
Download in electronic PDF format for $75
Abstract: A previously developed stability-indicating high-performance
liquid chromatographic assay method was used to
investigate the stability of glycopyrrolate in oral liquid
dosage forms (0.5 mg/mL) that contained a 0.05-M phosphate
buffer of pH 5.6 and either 10% sorbitol or 10% sucrose
as the sweetening agent. The decomposition product
and sorbitol or sucrose did not interfere with the assay procedure.
The liquid dosage forms were prepared using commercially
available powder. After 129 days of storage at
25°C, the loss in potency was less than 6%. The physical
appearance of the dosage forms did not change during the
study period. The pH value of the dosage forms in sorbitol
did not change from the original value of 5.6. The pH value
of the dosage forms in sucrose decreased from 5.6 to 4.8
after 129 days of storage at 25°C.
Related Keywords:
Glycopyrrolate, stability of oral liquid dosage forms
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Gupta Vishnu D
|
Sep/Oct 2003
Pg. 386-388
|
Stability of an Oral Liquid Dosage Form of Glycopyrrolate Prepared from Tablets
Gupta Vishnu D
|
Nov/Dec 2001
Pg. 480-481
|
Long-term Stability of Zonisamide, Amitriptyline, and Glycopyrrolate in Extemporaneously Prepared Liquid-dosage Forms at Two Temperatures
Nahata Milap C
|
Mar/Apr 2016
Pg. 164-166
|
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
|
Jul/Aug 2008
Pg. 372-374
|
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Sep/Oct 2009
Pg. 445-446
|
Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Gupta Vishnu D, Sood Arun
|
Mar/Apr 2005
Pg. 165-166
|
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Nov/Dec 2005
Pg. 484-486
|
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Gupta Vishnu D
|
May/Jun 2007
Pg. 259-261
|
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Gupta Vishnu D, Gupta Vikas S
|
Jan/Feb 2011
Pg. 78-80
|
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
|
Jul/Aug 2022
Pg. 342-351
|
Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form
Gupta Vishnu D
|
Jul/Aug 2007
Pg. 347-348
|
Stability of Oral Liquid Dosage Forms of Ethacrynic Acid
Gupta Vishnu D, Ling Jie
|
May/Jun 2001
Pg. 232-233
|
Stability of Bethanechol Chloride Oral Liquid Dosage Forms
Gupta Vishnu D, Maswoswe J
|
Jul/Aug 1997
Pg. 278-279
|
Stability of Ciprofloxacin in Extemporaneous Oral Liquid Dosage Form
Johnson Cary E, Wong Douglas V, Hoppe Heather L, Bhatt-Mehta Varsha
|
Jul/Aug 1998
Pg. 314-317
|
Physicochemical and Microbiological Stability of Compounded Clonidine Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt®
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Johnson Jyra, Graves Richard A
|
Jul/Aug 2024
Pg. 334-343
|
Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Nahata Milap C
|
Sep/Oct 2015
Pg. 428-431
|
Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage
Kumaravelrajan Rajagopal, Karthik B, Venkatasan Suba
|
Nov/Dec 2022
Pg. 516-521
|
Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography
Gupta Vishnu D
|
May/Jun 2000
Pg. 233-235
|
Unit Dose Packaging and Repackaging of Solid and Liquid Dosage Forms in an Institutional Setting
McElhiney Linda F
|
Jan/Feb 2010
Pg. 32-38
|
Basics of Compounding: Foam Dosage Forms
Allen Loyd V Jr
|
Jul/Aug 2013
Pg. 312-322
|
| Return to Top |
