Chemical Stability of Hydrocortisone in Humco Simple Syrup and Ora-Sweet Vehicle
Download in electronic PDF format for $75
Abstract: The chemical stability of hydrocortisone in two different commercially available vehicles for compounding oral liquid dosage forms has been studied using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. Hydrocortisone was more stable in Ora-Sweet vehicle than in Humco simple syrup. After 71 days of storage at 60°C , the percent of hydrocortisone retained in Humco simple syrup was 62.8 (initial pH value of the dosage form was 5.2) versus 67.7 in Ora-Sweet vehicle (initial pH value of the dosage form was 4.3). Due to the hydrolysis of sugar, the physical appearances of both the dosage forms gradually changed from almost colorless to yellow. Citric acid, which was present only in the Ora-Sweet vehicle, did not adversely affect the stability of hydrocortisone.
Related Keywords:
Vishnu D. Gupta, PhD, hydrocortisone, oral liquid vehicles, stability
Related Categories:
EXCIPIENTS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE
Printer-Friendly Version
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Chemical Stability of Hydrocortisone in Humco Simple Syrup and Ora-Sweet Vehicle
Gupta Vishnu D
|
Jan/Feb 2010
Pg. 76-77
|
Oral Liquid Vehicles, Featured Excipient:
Allen Loyd V Jr
|
Jan/Feb 2001
Pg. 65-67
|
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Gupta Vishnu D
|
May/Jun 2007
Pg. 259-261
|
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
|
Jul/Aug 2008
Pg. 372-374
|
Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
|
Sep/Oct 2021
Pg. 431-439
|
Quality Control and Physical and Chemical Stability of Hydrocortisone Oral Suspension: An Interlaboratory Study
Santoveña A, Llabrés M, Fariña JB
|
Sep/Oct 2010
Pg. 430-435
|
Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition
Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard
|
Sep/Oct 2014
Pg. 427-431
|
Stability of Verapamil Hydrochloride in SyrSpend SF Compared to Sorbitol Containing Syrup and Suspending Vehicles
Voudrie Mark A, Alexander Bridget, Allen D Brett
|
May/Jun 2011
Pg. 255-258
|
Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
Manchanda Arushi, Laracy Melissa, Savji Taslim, Bogner Robin H
|
Jan/Feb 2018
Pg. 66-75
|
Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Nahata Milap C
|
Sep/Oct 2015
Pg. 428-431
|
Stability of Prednisone in Oral Mix Suspending Vehicle
Friciu Mihaela, Plourde Kevin, Leclair Grégoire, Danapoulos Panagiota, Savji Taslim
|
Jul/Aug 2015
Pg. 337-339
|
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Gupta Vishnu D, Gupta Vikas S
|
Jan/Feb 2011
Pg. 78-80
|
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Sep/Oct 2009
Pg. 445-446
|
Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Gupta Vishnu D, Sood Arun
|
Mar/Apr 2005
Pg. 165-166
|
Hydrocortisone Hemisuccinate 2 mg/mL or Hydrocortisone Sodium Phosphate 2 mg/mL in SyrSpend SF pH4
Allen Loyd V Jr
|
Jul/Aug 2020
Pg. 315
|
Basics of Compounding: Vehicles for Compounded Oral Liquid Medications: A Review
Cutaia Kara, Chablani Lipika, Zhao Fang
|
Nov/Dec 2018
Pg. 480-489
|
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Nov/Dec 2005
Pg. 484-486
|
Sterile Basics: Intravenous Admixture Compounding, Part 2: Parenteral Vehicle Considerations
Allen Loyd V Jr
|
May/Jun 2023
Pg. 223-229
|
Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations
Visser J Carolina, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J
|
May/Jun 2018
Pg. 247-251
|
Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form
Gupta Vishnu D
|
Jul/Aug 2007
Pg. 347-348
|
| Return to Top |
