Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

A Simplified Extemporaneously Prepared Potassium Chloride Oral Solution

Author(s):  Tannous Elias, Tal Yana, Amarny Kamal

Issue:  Sep/Oct 2016 - Volume 20, Number 5
View All Articles in Issue

Page(s):  438-439

A Simplified Extemporaneously Prepared Potassium Chloride Oral Solution Page 1
A Simplified Extemporaneously Prepared Potassium Chloride Oral Solution Page 2

Download in electronic PDF format for $75

Abstract:  Although commercial preparations of oral potassium supplements are usually available, there are times when our Medical Center is faced with situations in which the oral solution of potassium chloride is not available. This solution is necessary for our pediatric outpatients who cannot swallow tablets and need an oral solution. Moreover, there are no studies available which describe an extemporaneously prepared potassium chloride oral solution on which we can rely for assigning a beyond-use date. The aim of this study was to formulate an extemporaneous pediatric oral solution of potassium chloride and to determine the physical and chemical stability of this preparation. We prepared 1 mMoL/mL by withdrawing 25 mL of potassium chloride 14.9%. Ora-Sweet SF was added to 50 mL in a metered flask. The solution was kept refrigerated (2°C to 8°C). Samples were withdrawn to measure potassium concentration, pH, and microbial overgrowth. The test was performed by our biochemical laboratory. The oral solution of potassium chloride 1 mMoL/mL stored at 2°C to 8°C maintained at least 91% of the initial concentration for 28 days. There were no notable changes in pH, and the solution remained physically stable with no visual microbial growth. The oral solution of potassium chloride 1 mMoL/mL prepared in Ora-Sweet and stored at 2°C to 8°C in amber glass bottles is expected to remain stable for 28 days.

Related Keywords: potassium chloride, oral solution, electrolyte disorders, metabolic abnormalities, electrolyte supplementation, pediatric electrolyte supplement solutions, drug shortage, stability

Related Categories: NUTRITION AND NUTRICEUTICALS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, STORAGE

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
A Simplified Extemporaneously Prepared Potassium Chloride Oral Solution
Tannous Elias
, Tal Yana, Amarny Kamal
Sep/Oct 2016
Pg. 438-439

Quality Control Analytical Methods: Testing of Electrolytes Solutions
Vu Nicole
Jan/Feb 2009
Pg. 53-55

Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions
Quay Irene
, Tan Edward
Jul/Aug 2001
Pg. 323-324

Potassium Chloride 2-mEq/mL Injection
Allen Loyd V Jr
Jan/Feb 2014
Pg. 67

Basics of Compounding for Disorders of the External Ear
Allen Loyd V Jr
Jan/Feb 2004
Pg. 46-48

Stability Issues for Compounding Extemporaneously Prepared Oral Formulations for Pediatric Patients
Schotik Debora
Jan/Feb 2001
Pg. 9-12

Potassium Chloride 1 mmol/mL in Ora-Sweet SF
Allen Loyd V Jr
Jan/Feb 2020
Pg. 61

Basics of Compounding: Compounding Irrigation Solutions for Sterile and Nonsterile Preparations
Allen Loyd V Jr
Nov/Dec 2017
Pg. 481-486

Electrolyte Lollipop (Adult)
Allen Loyd V Jr
Jan/Feb 2009
Pg. 70

Pediatric Compounding: Coloring Outside the Lines
Preckshot John
Jan/Feb 2001
Pg. 6-8

Electrolyte and Rehydration Powder for Solution-Example of Powder Formulations
Allen Loyd V Jr
Jan/Feb 2001
Pg. 38

Compatibility and Stability of Palonosetron Hydrochloride with Lactated Ringer's, Hetastarch in Lactated Electrolyte, and Mannitol Injections During Simulated Y-Site Administration
Ben Michel
, Kupiec Thomas C, Trusley Craig, Trissel Lawrence A
Sep/Oct 2008
Pg. 460-462

Utilization of Compounded Medications in an Oral Medicine Practice
Stock Shannon
, Rubino Katie, Woo Sook-Bon, Margolis Arthur, Thomas Irena, Aboalela Ali, Treister Nathaniel
Mar/Apr 2016
Pg. 155-158

Formulation, Physical Stability, and the Clinical Effectiveness of Extemporaneous Ivermectin Oral Solution
Zaid Abdel-Naser
, Zaaror Yara Abu, Qaddumi Aiman, Ratrout Ala, Ahmad Ayda, Hamad Emad, Kittana Naim
Nov/Dec 2021
Pg. 523-527

Citric Acid, Potassium Citrate, and Sodium Citrate Solution
Allen Loyd V Jr
Jul/Aug 2011
Pg. 335

Formulation and Stability of Solutions
Akers Michael J
Jan/Feb 2016
Pg. 41-45

Chemical and Physical Compatibility of an Intravenous Solution of Epinephrine with Calcium Chloride
Weeks Phillip A
, Teng Yang, Wu Lei, Sun Mary, Yang Zhen, Chow Diana S-L
Mar/Apr 2014
Pg. 152-158

Potassium Bromide 500-mg/mL Oral Solution for Animals
Allen Loyd V Jr
Jul/Aug 1997
Pg. 261

Potassium Iodide 130-mg Capsules and Potassium Iodide 16-mg/mL Oral Liquid
Allen Loyd V Jr
Jan/Feb 2003
Pg. 61

Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Kabiche Djamila
, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
Mar/Apr 2017
Pg. 160-163

Return to Top