Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Stability of Fentanyl Citrate in Polyolefin Bags

Author(s):  Donnelly Ronald F

Issue:  Nov/Dec 2016 - Volume 20, Number 6
View All Articles in Issue

Page(s):  514-516

Stability of Fentanyl Citrate in Polyolefin Bags Page 1
Stability of Fentanyl Citrate in Polyolefin Bags Page 2
Stability of Fentanyl Citrate in Polyolefin Bags Page 3

Download in electronic PDF format for $75

Abstract:  Fentanyl is used to manage pain because it is a potent lipophilic opiate agonist. The stability of fentanyl in polyolefin bags when diluted to either 10 µg/mL or 50 µg/mL with sodium chloride 0.9% has not been studied. The chemical stability of fentanyl 50 µg/mL packaged in polyvinyl chloride bags has been studied, however, the stability in polyolefin bags is lacking. Polyolefin bags were aseptically filled with either 10-µg/mL or 50-µg/mL fentanyl solution. Containers were then stored at either 5°C and protected from light or 22°C and exposed to light for 93 days. Fentanyl peaks were monitored using a stability-indicatin high-performance liquid chromatographic method. Changes to color, clarity, and pH were also monitored. There were no signs of chemical degradation of fentanyl packaged in polyolefin bags at either 5°C or 22°C after storage for 93 days. Over the course of the study, all solutions remained colorless and clear. The pH showed a slight decrease during the 93 days of storage. The stability of both undiluted (50-µg/mL) and diluted (10-µg/mL) fentanyl solutions when packaged in polyolefin bags was 93 days when stored at either 5°C or 22°C.

Related Keywords: Ronald F. Donnelly, MSc (Chem), BSc (Pharm), fentanyl, pain relief, pain control, lipophilic opiate agonist, stability, packaging, polyolefin bags

Related Categories: PACKAGING, PAIN MANAGEMENT, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Stability of Fentanyl Citrate in Polyolefin Bags
Donnelly Ronald F
Nov/Dec 2016
Pg. 514-516

Chemical Stability of Fentanyl in Polypropylene Syringes and Polyvinylchloride Bags
Donnelly Ronald F
Nov/Dec 2005
Pg. 482-483

Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags
Zhang Yanping
, Trissel Lawrence A
May/Jun 2002
Pg. 226-229

Prolonged In-use Stability of Reconstituted Herceptin in Commercial Intravenous Bags
Nalenz Heiko
, Köpf Ellen, Dietel Elke
Sep/Oct 2018
Pg. 417-423

Long-term Stability of Vancomycin Hydrochloride in Glucose 5% Polyolefin Bags: The Brand Name Versus a Generic Product
Huvelle Sophie
, Godet Marie, Hecq Jean-Daniel, Gillet Patricia, Jamart Jacques, Galanti Laurence M
Sep/Oct 2016
Pg. 416-420

Long-term Stability of Esomeprazole in 5% Dextrose Infusion Polyolefin Bags at 5°C ± 3°C after Microwave Freeze-thaw Treatment
Hecq Jean-Daniel
, Rolin Catherine, Godet Marie, Gillet Patricia, Jamart Jacques, Galanti Laurence M
Nov/Dec 2015
Pg. 521-524

Stability of Morphine Sulfate in Polypropylene Infusion Bags for Use in Patient-Controlled Analgesia Pumps for Postoperative Pain Management
Nguyen-Xuan Tho
, Griffiths William, Kern Christian, Van Gessel Elisabeth, Bonnabry Pascal
Jan/Feb 2006
Pg. 69-73

Long-term Stability of Morphine Hydrochloride in 0.9% NaCl Infusion Polyolefin Bags After Freeze-thaw Treatment and in Polypropylene Syringes at 5°C ± 3°C
Hecq J-D
, Godet M, Gillet P, Jamart J, Galanti L
Jan/Feb 2014
Pg. 78-82

Stability of Gentamicin Sulfate and Tobramycin Sulfate in AutoDose Infusion System Bags
Xu Quanyun A
, Trissel Lawrence A, Saenz Christopher A, Ingram Delshalonda S
Mar/Apr 2002
Pg. 152-154

Chemical Stability of Admixtures Combining Ziconotide with Fentanyl or Sufentanil During Simulated Intrathecal Administration
Shields David E
, Aclan Jennifer, Szatkowski Aaron
Sep/Oct 2008
Pg. 463-466

Stability of Venlafaxine Immediate-Release Suspensions
Donnelly Ronald F
, Wong Keith, Goddard Rob, Johanson Christel
Jan/Feb 2011
Pg. 81-84

Compounded Analgesic Therapy for Disorders of Movement: Arthritis, Neuropathic Pain, and Postpolio Syndrome
Brown Scott
, Erickson Brian, Muller George, Bryant-Snure Susan J, Mestayer Richard F III
May/Jun 2010
Pg. 182-192

Topical Medications for Orofacial Neuropathic Pain
Bramwell Bethany L
May/Jun 2010
Pg. 200-203

pH Stability of Injectable Fentanyl, Bupivacaine, or Clonidine Solution or a Ternary Mixture in 0.9% Sodium Chloride in Two Types of Polypropylene Syringes
Jappinen Annaliisa L
, Kokki H, Rasi A S, Naaranlahti Toivo J
Nov/Dec 2002
Pg. 471-474

Fentanyl Citrate 50-mcg/mL Injection
Allen Loyd V Jr
Sep/Oct 2017
Pg. 411

Stability of Dexmedetomidine in 0.9% Sodium Chloride in Two Types of Intravenous Infusion Bags
Marquis Kathleen
, Hohlfelder Benjamin, Szumita Paul M
Sep/Oct 2017
Pg. 436-439

Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions
Wolfe Amanda
, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan
Jul/Aug 2021
Pg. 330-335

Compounded Pain Formulations: What is the Evidence?
Asbill Scott
, Sweitzer Sarah M, Spigener Shuler, Romero-Sandoval Alfonso
Jul/Aug 2014
Pg. 278-286

Compounded Pain Formulations: What is the Evidence?
Asbill Scott
, Sweitzer Sarah M, Spigener Shuler, Romero-Sandoval Alfonso
Mar/Apr 2024
Pg. 100-109

Fentanyl Troche Protocol
Roberts Bruce T
Nov/Dec 2000
Pg. 447

Return to Top