IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Investigation of the Physical, Chemical, and Microbiological Stability of Oral Solutions Compounded with Herbals

Author(s):  Khokhlova Kateryna O, Zdoryk Oleksandr A

Issue:  May/Jun 2018 - Volume 22, Number 3
View All Articles in Issue

Abstract:  The physical, chemical, and microbiological stability of a compounded oral solution with the active ingredients herbal tinctures of valerian and motherwort with sedative action for pediatric treatment was studied. Evaluations for physical, chemical, and microbiological stability were performed initially and throughout the storage period. Physical stability of the oral solution was assessed by coloration, clarity, and pH of the solution. The physical appearance of the oral solution did not change throughout the study period. The chemical stability of the oral solution was evaluated by means of a stability-indicating high-performance thin-layer chromatography analytical technique, identification tests, and assay method of sodium bromide. The microbiological stability of the oral solution was investigated by using the European Pharmacopoeia method using the acceptance criteria for nonsterile aqueous preparations for oral use. It was found that the compounded oral solution was stable for at least 21 days at 25°C ± 2°C/60% RH and 5°C ± 3°C, when protected from light.

Related Keywords: Kateryna O. Khokhlova, PhD, Oleksandr A. Zdoryk, PhD, physical stability, chemical stability, microbiological stability, herbal tinctures, valerian, motherwort, herbs, formulation, sedative, sedation, children, bromides, central nervous system disorders, CNS, Leda solution, hypnotic, valerenic acids, flavonoids

Related Categories: FORMULATIONS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, ALTERNATIVE/COMPLEMENTARY THERAPIES, NEUROLOGY, STORAGE

Printer-Friendly Version




Download in electronic PDF format for $35

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Investigation of the Physical, Chemical, and Microbiological Stability of Oral Solutions Compounded with Herbals Khokhlova Kateryna O, Zdoryk Oleksandr A May/Jun 2018 240-246 Buy
Investigation of Physical and Chemical Stability of an Ointment with Herbals Zdoryk Oleksandr A, Khokhlova Kateryna O, Georgiyants Victoriya A, Vyshnevska Liliia I May/Jun 2014 248-252 Buy
Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard Sep/Oct 2014 427-431 Buy
Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox) Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel Jul/Aug 2017 322-329 Buy
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes Xu Quanyun A, Trissel Lawrence A, Pham Lien Jan/Feb 2002 66-69 Buy
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes Trissel Lawrence A, Xu Quanyun A, Pham Lien Jan/Feb 2002 70-73 Buy
Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs. Xu Quanyun A, Trissel Lawrence A, Pham Lien May/Jun 2004 228-230 Buy
Physico-chemical Stability of MabThera Drug-product Solution for Subcutaneous Injection under In-use Conditions with Different Administration Materials Mueller Claudia, Dietel Elde, Heynen Severin R, Nalenz Heiko, Goldbach Pierre, Mahler Hanns-Christian, Schmidt Johannes, Grauschopf Ulla, Schoenhammer Karin May/Jun 2015 261-267 Buy
Physical and Chemical Stability of Estriol 0.025% to 1% Vaginal Creams (VersaBase) Ip Kendice, Shan Ashley, Yan Wei, Banov Daniel Nov/Dec 2018 504-511 Buy
Stability of Compounded Ursodiol Suspensions in PCCA Base, SuspendIt Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Nguyen Anh TQ, Miller Valicia, Morris Tommy C, Graves Richard A Jan/Feb 2019 70-76 Buy