Investigation of the Physical, Chemical, and Microbiological Stability of Oral Solutions Compounded with Herbals

Khokhlova, Kateryna O; Zdoryk, Oleksandr A

Abstract

Investigation of the Physical, Chemical, and Microbiological Stability of Oral Solutions Compounded with Herbals

Author(s): Khokhlova Kateryna O, Zdoryk Oleksandr A

Issue: May/Jun 2018 - Volume 22, Number 3

View All Articles in Issue

Page(s): 240-246

Download in electronic PDF format for $75

Abstract

The physical, chemical, and microbiological stability of a compounded oral solution with the active ingredients herbal tinctures of valerian and motherwort with sedative action for pediatric treatment was studied. Evaluations for physical, chemical, and microbiological stability were performed initially and throughout the storage period. Physical stability of the oral solution was assessed by coloration, clarity, and pH of the solution. The physical appearance of the oral solution did not change throughout the study period. The chemical stability of the oral solution was evaluated by means of a stability-indicating high-performance thin-layer chromatography analytical technique, identification tests, and assay method of sodium bromide. The microbiological stability of the oral solution was investigated by using the European Pharmacopoeia method using the acceptance criteria for nonsterile aqueous preparations for oral use. It was found that the compounded oral solution was stable for at least 21 days at 25°C ± 2°C/60% RH and 5°C ± 3°C, when protected from light.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
May/Jun 2018 Pg. 240-246	Investigation of the Physical, Chemical, and Microbiological Stability of Oral Solutions Compounded with Herbals Author(s): Khokhlova Kateryna O, Zdoryk Oleksandr A
May/Jun 2014 Pg. 248-252	Investigation of Physical and Chemical Stability of an Ointment with Herbals Author(s): Zdoryk Oleksandr A, Khokhlova Kateryna O, Georgiyants Victoriya A, Vyshnevska Liliia I
Jul/Aug 2017 Pg. 322-329	Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox) Author(s): Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel
Sep/Oct 2021 Pg. 431-439	Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Sep/Oct 2014 Pg. 427-431	Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition Author(s): Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard
Jan/Feb 2002 Pg. 66-69	Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Jan/Feb 2002 Pg. 70-73	Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
Jul/Aug 2022 Pg. 330-335	Physicochemical and Microbiological Stability of Vancomycin 10-mg/mL Intravitreal Syringes Author(s): Bartoll Aaron Puplà, Bellés Medall Maria Dolores, Peñarrocha Josep Edo, Escrig Laura Solaz, Clemente Ruben Eguren, Azuara Julia Bodega, Piqueres Raul Ferrando
Jan/Feb 2021 Pg. 82-87	Physical-chemical Stability of Compounded Sildenafil 100-mg Rapid-dissolving Tablets Author(s): Cheung Matthew, Zhao Fang, Dave Vivek S
Nov/Dec 2018 Pg. 504-511	Physical and Chemical Stability of Estriol 0.025% to 1% Vaginal Creams (VersaBase) Author(s): Ip Kendice, Shan Ashley, Yan Wei, Banov Daniel
May/Jun 2022 Pg. 248-254	Physical and Chemical Stability of Pharmaceutical Preparation of Bumetanide and Scopolamine Author(s): Catry Emilie, Colsoul Marie-Louise, Closset Melanie, Hubert Justine, Soumoy Laura, Bihin Benoit, Thiry Emmanuell, Jamart Jacques, Hecq Jean-Daniel, Galanti Laurence
Jan/Feb 2002 Pg. 74-76	Physical and Chemical Stability of Hydromorphone Hydrochloride 1.5- and 80-mg/mL Packaged in Plastic Syringes Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
May/Jun 2004 Pg. 228-230	Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs. Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Nov/Dec 2021 Pg. 523-527	Formulation, Physical Stability, and the Clinical Effectiveness of Extemporaneous Ivermectin Oral Solution Author(s): Zaid Abdel-Naser, Zaaror Yara Abu, Qaddumi Aiman, Ratrout Ala, Ahmad Ayda, Hamad Emad, Kittana Naim
Jul/Aug 2022 Pg. 342-351	Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Mar/Apr 2021 Pg. 169-175	Physicochemical and Microbiological Stability of Compounded Metronidazole Suspensions in PCCA SuspendIt Author(s): Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Le Giang, Morris Tommy C, Graves Richard A
Mar/Apr 2023 Pg. 160-168	Physicochemical and Microbiological Stability of Pyrimethamine in Paraben-free PCCA Base, SuspendIt Author(s): Pramar Yashoda V, Mandal Tarum K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Jul/Aug 2023 Pg. 330-339	Physiochemical and Microbiological Stability of Azathioprine Suspensions in PCCA Base, SuspendIt Author(s): Pramar Yahoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Jan/Feb 2016 Pg. 41-45	Formulation and Stability of Solutions Author(s): Akers Michael J
May/Jun 2020 Pg. 242-245	Physicochemical Stability and Compatibility of Revefenacin (LAMA) and Formoterol Fumarate (LABA) Inhalation Solution Admixture Author(s): Ngim Kenley, Patel Jalpa